Ankit Bhattacharjee | Searcharxiv

arXiv2026

Dose-PlanNet: Physics Based Radiotherapy Dose Prediction with Deep Learning

Automating prostate radiotherapy treatment planning is dosimetrically complex, particularly for extreme hypofractionated regimens. In this study, we introduce Dose-PlanNet, a physics-guided 3D deep learning architecture designed to predict dose distributions. This model's performance was evaluated on a cohort of patients treated in a prospective trial where two different dose fractionation regimens were employed. Dose-PlanNet achieved comparable target coverage ($D_{95}$), though statistical analysis revealed a marginal reduction in target homogeneity ($p<0.001$) offset. However the model achieved statistically significant improvements in high-dose organ-at-risk sparing ($p<0.001$). When evaluated against strict Prospective Randomized protocol volumetric constraints, automated plans met prespecified clinical acceptance criteria in $11$ out of $14$ Moderate Hypofraction Arm plans and $9$ out of $12$ Stereotactic Body Radiation Therapy Arm plans. This pipeline demonstrates that physics-informed deep learning can accelerate radiotherapy workflows while safely maintaining the stringent dosimetric quality required for high-precision clinical deployment.

physics.med-ph↗

arXiv2026

Robust Dual-Signal Fusion: Hybrid Neuro-Symbolic Gating with Compressed Chain-of-Thought Refinement for Irony Detection in Social Media Texts

Small-scale Large Language Models (LLMs) natively default to literal semantic interpretations, making few-shot irony detection a persistent challenge in noisy, user-generated text. In this study, we show that, despite this limitation, inference from compact LLMs can still be effectively harnessed for this task. We introduce the Robust Dual-Signal (RDS) Fusion framework, a hybrid neuro-symbolic architecture that utilizes a compressed Chain-of-Thought (CoT) of an LLM, alongside a static, pretrained RoBERTa and a symbolic prior module in two downstream fusions. RDS Fusion demonstrates better performance than an unrestricted reasoning ablation, while requiring substantially lower inference time. We also find that in our experiments, unrestricted reasoning does not yield better results than restricted reasoning. Evaluated on a strictly held-out TweetEval test set ($N=734$), RDS Fusion achieves $78.1\%$ accuracy and a Macro F1 of $0.777$, which is comparable to a finetuned BERTweet-base. On the heavily imbalanced iSarcasm dataset, the frozen CoT pipeline suppresses $22.5\%$ of baseline false positives, yielding a Macro F1 of $0.6726$ and Ironic F1 of $0.4821$, outperforming multiple heavily supervised SemEval transformer ensembles. Paired McNemar's tests show that, while adding the symbolic prior to the neural baseline yields an insignificant gain, and the RDS Fusion is statistically insignificant compared to the combined RoBERTa and symbolic prior ablation; the concurrent fusion achieves a statistically significant improvement over the standalone baseline ($p=0.005$).

cs.CL↗