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Antonio Gómez-Corral

Publications and source records attributed to Antonio Gómez-Corral.

2 recordsLinked to original sources

A computational approach to extreme values and related hitting probabilities in level-dependent quasi-birth-death processes

This paper analyzes the dynamics of a level-dependent quasi-birth-death process ${\cal X}=\{(I(t),J(t)): t\geq 0\}$, i.e., a bi-variate Markov chain defined on the countable state space $\cup_{i=0}^{\infty} l(i)$ with $l(i)=\{(i,j) : j\in\{0,...,M_i\}\}$, for integers $M_i\in\mathbb{N}_0$ and $i\in\mathbb{N}_0$, which has the special property that its $q$-matrix has a block-tridiagonal form. Under the assumption that the first passage to the subset $l(0)$ occurs in a finite time with certainty, we characterize the probability law of $(τ_{\max},I_{\max},J(τ_{\max}))$, where $I_{\max}$ is the running maximum level attained by process ${\cal X}$ before its first visit to states in $l(0)$, $τ_{\max}$ is the first time that the level process $\{I(t): t\geq 0\}$ reaches the running maximum $I_{\max}$, and $J(τ_{\max})$ is the phase at time $τ_{\max}$. Our methods rely on the use of restricted Laplace-Stieltjes transforms of $τ_{\max}$ on the set of sample paths $\{I_{\max}=i,J(τ_{\max})=j\}$, and related processes under taboo of certain subsets of states. The utility of the resulting computational algorithms is demonstrated in two epidemic models: the SIS model for horizontally and vertically transmitted diseases; and the SIR model with constant population size.

math.PR↗

A Markov chain model to investigate the spread of antibiotic-resistant bacteria in hospitals

Ordinary differential equation (ODE) models used in mathematical epidemiology assume explicitly or implicitly large populations. For the study of infections in a hospital this is an extremely restrictive assumption as typically a hospital ward has a few dozen, or even fewer, patients. This work reframes a well-known model used in the study of the spread of antibiotic-resistant bacteria in hospitals, to consider the pathogen transmission dynamics in small populations. In this vein, this paper proposes a Markov chain model to describe the spread of a single bacterial species in a hospital ward where patients may be free of bacteria or may carry bacterial strains that are either sensitive or resistant to antimicrobial agents. We determine the probability law of the \emph{exact} reproduction number ${\cal R}_{exact,0}$, which is here defined as the random number of secondary infections generated by those patients who are accommodated in a predetermined bed before a patient who is free of bacteria is accommodated in this bed for the first time. Specifically, we decompose the exact reproduction number ${\cal R}_{exact,0}$ into two contributions allowing us to distinguish between infections due to the sensitive and the resistant bacterial strains. Our methodology is mainly based on structured Markov chains and the use of related matrix-analytic methods. This guarantees the compatibility of the new, finite-population model, with large population models present in the literature and takes full advantage, in its mathematical analysis, of the intrinsic stochasticity.

q-bio.PE↗