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Antony Garcia

Publications and source records attributed to Antony Garcia.

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Interpretable and Calibrated Classification of Clinical Data Using Supervised Feature Binarization

Black-box models limit the adoption of artificial intelligence in medicine because their predictions are difficult to interpret and reproduce. We present a statistically grounded framework for interpretable, rule-based clinical classification using the Bernoulli Naïve Bayes (BNB) model. Supervised chi-square-guided binarization converts continuous variables into binary indicators by selecting thresholds that maximize association with the clinical outcome within the training folds, which allows BNB to operate on continuous medical data without sacrificing transparency. On three benchmark datasets, Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction, the framework reached areas under the receiver operating characteristic curve of 0.800, 0.984, and 0.919, respectively. Probabilistic reliability was assessed with a leakage-safe cross-validated calibration analysis reporting Brier score and calibration intercept and slope, and post-hoc beta calibration improved probability calibration across datasets. These results indicate that an interpretable, statistically motivated framework can perform comparably to more complex models while providing explicit decision rules expressed in clinical units and calibrated risk estimates. A complete worked example further shows that model inference can be reproduced from a printed reference table using only basic arithmetic, without software or proprietary tools, supporting trustworthy and auditable use of artificial intelligence in clinical settings.

cs.LG

Smart Insole Human Activity Recognition for Continuous Monitoring in Elderly Care

Falls in older adults are often preceded by changes in mobility, balance, and postural transitions. This paper presents a wireless smart insole platform and machine-learning workflow for recognizing sitting, standing, walking, and unstable walking from plantar-pressure and inertial signals. Each insole integrates 16 active pressure-sensing locations and a six-dimensional IMU stream consisting of tri-axial acceleration and angular velocity. Data were collected from 15 healthy adults at 80~Hz and segmented into overlapping windows. Window length and candidate model families were first screened with stratified 10-fold cross-validation; the primary performance estimate was then obtained with participant-independent 5-fold Stratified Group cross-validation, ensuring that all windows from a participant remained in a single fold. Under this protocol, Histogram-Based Gradient Boosting (HGB) achieved macro-F1 scores of 0.954 and 0.959 for the left and right feet, respectively, and 0.980 with bilateral sensing. A compact 1D-CNN evaluated with the same participant-independent folds did not significantly outperform HGB ($p=0.0625$). The results show that low-profile footwear sensing can infer activity state from pressure and IMU measurements for participants unseen during training, establishing a basis for activity monitoring and fall prevention in elderly care.

cs.LG

Machine-Learning Assessment of the Predictive Value of Inflammatory Biomarkers for Cognitive Impairment in an Older Hispanic Adult Cohort

Small clinical tabular datasets require interpretable machine learning because deep learning is often impractical and ensemble models can be difficult to inspect. A key pitfall is that statistical significance does not necessarily imply predictive utility. Using data from the Panama Aging Research Initiative--Health Disparities (PARI-HD) cohort (n=165), we implemented a leakage-safe threshold-likelihood Bernoulli/Categorical Naive Bayes (BNB/CNB) classifier. Within every training fold, each continuous predictor was reduced to a supervised chi-square-derived state, while income entered the model through a categorical likelihood. All data-dependent steps were performed within repeated stratified 10-fold cross-validation with 30 repeats. The demographic baseline achieved a ROC-AUC of 0.630 +/- 0.017. I-309 (CCL1) was the dominant incremental feature, increasing AUC by 0.110, with paired DeLong tests yielding p<0.05 in 100% of repeats. In the pre-specified primary analysis, I-309 produced a fixed-partition DeLong p=0.0018, with robustness assessed across 200 random partitions, where the median p-value was 0.0011. Within the exploratory family of 18 candidate markers, I-309 achieved a Benjamini-Hochberg-adjusted q=0.032 on the frozen partition and satisfied q<0.05 in 85% of random partitions, whereas no other marker demonstrated reliable incremental predictive value. Because the fitted model is an inspectable table of thresholds and class-conditional probabilities, these results identify I-309/CCL1 as an interpretable candidate feature for tabular prediction of cognitive impairment, pending external validation.

cs.LG