Ariane Ernst | Searcharxiv

arXiv2026

Birth of the Coil: another Milestone towards a fully reproducible low-field MRI scanner for head-imaging

Low-field magnetic resonance imaging (MRI) provides an accessible, portable, and low-cost alternative to high-field scanners, expanding diagnostic imaging to point-of-care settings. However, widespread adoption is fundamentally hindered by a severely reduced signal-to-noise ratio (SNR). At low frequencies, radiofrequency (RF) coil conductor losses - rather than tissue sample losses - predominantly govern the system's total noise, making meticulous RF coil optimization critical to recovering image quality. This work presents an open-source, optimized solenoid head coil tailored for the 50 mT open-source scanner (OSII ONE v2.1). The paper validates production reproducibility across three independent international institutions and introduce an open-source connector with integrated digital circuitry for coil identification and DC or logic signals. Comprehensive benchtop measurements, Electromagnetic Interference (EMI) coupling analysis, Specific Absorption Rate (SAR) safety simulations, and phantom and human volunteer imaging confirm the design's efficacy, safety, and reproducibility. The results of the paper, when combined with the material provided in the open-source dedicated repositories, set the basis for a fully reliable and reproducible component for the open-source OSII ONE MRI scanner. In addition, the same optimization strategy and design material can be exploited for designing other RF coils for imaging of other body parts.

physics.med-ph↗

arXiv2023

Rate-limiting recovery processes in neurotransmission under sustained stimulation

At chemical synapses, an arriving electric signal induces the fusion of vesicles with the presynaptic membrane, thereby releasing neurotransmitters into the synaptic cleft. After a fusion event, both the release site and the vesicle undergo a recovery process before becoming available for reuse again. Of central interest is the question which of the two restoration steps acts as the limiting factor during neurotransmission under high-frequency sustained stimulation. In order to investigate this question, we introduce a novel non-linear reaction network which involves explicit recovery steps for both the vesicles and the release sites, and includes the induced time-dependent output current. The associated reaction dynamics are formulated by means of ordinary differential equations (ODEs), as well as via the associated stochastic jump process. While the stochastic jump model describes a single release site, the average over many release sites is close to the ODE solution and shares its periodic structure. The reason for this can be traced back to the insight that recovery dynamics of vesicles and release sites are statistically almost independent. A sensitivity analysis on the recovery rates based on the ODE formulation reveals that neither the vesicle nor the release site recovery step can be identified as the essential rate-limiting step but that the rate-limiting feature changes over the course of stimulation. Under sustained stimulation the dynamics given by the ODEs exhibit transient changes leading from an initial depression of the postsynaptic response to an asymptotic periodic orbit, while the individual trajectories of the stochastic jump model lack the oscillatory behavior and asymptotic periodicity of the ODE-solution.

math.DS↗