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Arina Odnoblyudova

Publications and source records attributed to Arina Odnoblyudova.

2 recordsLinked to original sources

A computationally-tractable measure of global sensitivity for sampling-based Bayesian inference

Bayesian inference can often be sensitive to the choice of hyperparameters of the prior or likelihood, yet defining and quantifying this sensitivity in a principled and computationally feasible way remains challenging in practice. Unfortunately, existing sensitivity methods are rarely applicable in modern Bayesian workflows due to their high computational cost and poor performance in moderate to high dimensions. To address these limitations, we introduce a new approach to global sensitivity analysis based on the Fisher divergence. Our method only requires a set of samples from a reference posterior and the ability to evaluate score functions, making it broadly computationally tractable. Under mild regularity conditions, it controls changes in the whole posterior, and provides a bound on the impact of perturbations on the first two moments. We demonstrate these strengths on challenging Bayesian inference problems which are practically out of reach of existing approaches, including generalised Bayesian inference for unnormalised models, inference in Bayesian models of time series, and neural simulation-based inference.

stat.ME↗

Nonparametric modeling of the composite effect of multiple nutrients on blood glucose dynamics

In biomedical applications it is often necessary to estimate a physiological response to a treatment consisting of multiple components, and learn the separate effects of the components in addition to the joint effect. Here, we extend existing probabilistic nonparametric approaches to explicitly address this problem. We also develop a new convolution-based model for composite treatment-response curves that is more biologically interpretable. We validate our models by estimating the impact of carbohydrate and fat in meals on blood glucose. By differentiating treatment components, incorporating their dosages, and sharing statistical information across patients via a hierarchical multi-output Gaussian process, our method improves prediction accuracy over existing approaches, and allows us to interpret the different effects of carbohydrates and fat on the overall glucose response.

stat.ML↗