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Armin Lühr

Publications and source records attributed to Armin Lühr.

13 recordsLinked to original sources
arXiv2026

Combined photon-proton modeling of radiation-induced brain imaging changes supports variability in proton relative biological effectiveness and increased periventricular radiosensitivity

Purpose: Recent proton-only investigations of radiation-induced contrast enhancements (RICE) in brain tumor patients indicated variability in proton relative biological effectiveness (RBE) and increased radiosensitivity of the periventricular region (PVR). Because RBE is defined relative to a reference radiation, these studies required assumptions on the photon dose-response relationship. This study aimed to validate proton RBE variability and PVR radiosensitivity using predictive modeling of RICE in a combined photon-proton cohort. Methods and Materials: Predictive models for RICE detected on follow-up magnetic resonance imaging were developed in 152 intracranial tumor patients treated with photons or protons. Logistic regression was applied at the voxel level to model spatial occurrence and at the patient level to model incidence. A clinical RBE model was derived from voxel-wise comparisons of estimated risk between photon and proton irradiation. Results: In total, 128 RICE of various grades occurred in 64 patients. Voxel-level modeling validated absorbed dose (D), D multiplied by dose-averaged linear energy transfer (LETd) for proton therapy, and PVR as independent predictors of RICE. The model implied a variable proton RBE described by RBE=1+m$\cdot$LETd, with m=0.10 $μ$m/keV. At the patient level, the PVR D2ml based on this RBE achieved the highest predictive performance. Conclusions: RICE was spatially associated with dose and PVR proximity across photon and proton therapy, with an additional LET-dependent component after proton therapy. The cross-modality framework validates proton RBE variability against an observed photon reference rather than predefined reference assumptions, and supports PVR radiosensitivity as modality-independent. Accounting for variable proton RBE and the PVR as an organ at risk may improve risk assessment and mitigation of radiation-induced side effects.

physics.med-ph↗
arXiv2022

Clinical use and future requirements of relative biological effectiveness: survey among all european proton therapy centres

Background and purpose: The relative biological effectiveness (RBE) varies along the treatment field. However, in clinical practice, a constant RBE of 1.1 is assumed, which can result in undesirable side effects. This study provides an accurate overview of current clinical practice for considering proton RBE in Europe. Materials and Methods: A survey was devised and sent to all proton therapy centres in Europe that treat patients. The online questionnaire consisted of 39 questions addressing various aspects of RBE consideration in clinical practice, including treatment planning, patient follow-up and future demands. Results: All 25 proton therapy centres responded. All centres prescribed a constant RBE of 1.1, but also applied measures (except for one eye treatment centre) to counteract variable RBE effects such as avoiding beams stopping inside or in front of an organ at risk and putting restrictions on the minimum number and opening angle of incident beams for certain treatment sites. For the future, most centres (16) asked for more retrospective or prospective outcome studies investigating the potential effect of the effect of a variable RBE. To perform such studies, 18 centres asked for LET and RBE calculation and visualisation tools developed by treatment planning system vendors. Conclusion: All European proton centres are aware of RBE variability but comply with current guidelines of prescribing a constant RBE. However, they actively mitigate uncertainty and risk of side effects resulting from increased RBE by applying measures and restrictions during treatment planning. To change RBE-related clinical guidelines in the future more clinical data on RBE are explicitly demanded.

physics.med-ph↗
arXiv2017

Dosimetric evidence confirms computational model for magnetic field induced dose distortions of therapeutic proton beams

Given the sensitivity of proton therapy to anatomical variations, this cancer treatment modality is expected to benefit greatly from integration with magnetic resonance (MR) imaging. One of the obstacles hindering such an integration are strong magnetic field induced dose distortions. These have been predicted in simulation studies, but no experimental validation has been performed so far. Here we show the first measurement of planar distributions of dose deposited by therapeutic proton pencil beams traversing a one-Tesla transversal magnetic field while depositing energy in a tissue-like phantom using film dosimetry. The lateral beam deflection ranges from one millimeter to one centimeter for 80 to 180 MeV beams. Simulated and measured deflection agree within one millimeter for all studied energies. These results proof that the magnetic field induced proton beam deflection is both measurable and accurately predictable. This demonstrates the feasibility of accurate dose measurement and hence validates dose predictions for the framework of MR-integrated proton therapy.

physics.med-ph↗
arXiv2010

Analytical expressions for stopping-power ratios relevant for accurate dosimetry in particle therapy

In particle therapy, knowledge of the stopping-power ratios (STPRs) of the ion beam for air and water is necessary for accurate ionization chamber dosimetry. Earlier work has investigated the STPRs for pristine carbon ion beams, but here we expand the calculations to a range of ions (1 <= z <= 18) as well as spread out Bragg peaks (SOBPs) and provide a theoretical in-depth study with a special focus on the parameter regime relevant for particle therapy. The Monte Carlo transport code SHIELD-HIT is used to calculate complete particle-fluence spectra which are required for determining STPRs according to the recommendations of the International Atomic Energy Agency (IAEA). We confirm that the STPR depends primarily on the current energy of the ions rather than on their charge z or absolute position in the medium. However, STPRs for different sets of stopping-power data for water and air recommended by the International Commission on Radiation Units & Measurements (ICRU) are compared, including also the recently revised data for water, yielding deviations up to 2% in the plateau region. In comparison, the influence of the secondary particle spectra on the STPR is about two orders of magnitude smaller in the whole region up till the practical range. The gained insights enable us to propose an analytic approximation for the STPR for both pristine and SOBPs as a function of penetration depth, which parametrically depend only on the initial energy and the residual range of the ion, respectively.

physics.med-ph↗
arXiv2009

Full two-electron calculations of antiproton collisions with molecular hydrogen

Total cross sections for single ionization and excitation of molecular hydrogen by antiproton impact are presented over a wide range of impact energy from 1 keV to 6.5 MeV. A nonpertubative time-dependent close-coupling method is applied to fully treat the correlated dynamics of the electrons. Good agreement is obtained between the present calculations and experimental measurements of single-ionization cross sections at high energies, whereas some discrepancies with the experiment are found around the maximum. The importance of the molecular geometry and a full two-electron description is demonstrated. The present findings provide benchmark results which might be useful for the development of molecular models.

physics.atom-ph↗
arXiv2009

Collisions of antiprotons with hydrogen molecular ions

Time-dependent close-coupling calculations of the ionization and excitation cross section for antiproton collisions with molecular hydrogen ions are performed in an impact-energy range from 0.5 keV to 10 MeV. The Born-Oppenheimer and Franck-Condon approximations as well as the impact parameter method are applied in order to describe the target molecule and the collision process. It is shown that three perpendicular orientations of the molecular axis with respect to the trajectory are sufficient to accurately reproduce the ionization cross section calculated by [Sakimoto, Phys. Rev. A 71, 062704 (2005)] reducing the numerical effort drastically. The independent-event model is employed to approximate the cross section for double ionization and H+ production in antiproton collisions with H2.

physics.atom-ph↗
arXiv2009

Stopping power of antiprotons in H, H2, and He targets

The stopping power of antiprotons in atomic and molecular hydrogen as well as helium was calculated in an impact-energy range from 1 keV to 6.4 MeV. In the case of H2 and He the targets were described with a single-active electron model centered on the target. The collision process was treated with the close-coupling formulation of the impact-parameter method. An extensive comparison of the present results with theoretical and experimental literature data was performed in order to evaluate which of the partly disagreeing theoretical and experimental data are most reliable. Furthermore, the size of the corrections to the first-order stopping number, the average energy transferred to the target electrons, and the relative importance of the excitation and the ionization process for the energy loss of the projectile was determined. Finally, the stopping power of the H, H2, and He targets were directly compared revealing specific similarities and differences of the three targets.

physics.atom-ph↗
arXiv2008

Interaction of antiprotons with Rb atoms and a comparison of antiproton stopping powers of the atoms H, Li, Na, K, and Rb

Ionization and excitation cross sections as well as electron-energy spectra and stopping powers of the alkali metal atoms Li, Na, K, and Rb colliding with antiprotons were calculated using a time-dependent channel-coupling approach. An impact-energy range from 0.25 keV to 4000 keV was considered. The target atoms are treated as effective one-electron systems using a model potential. The results are compared with calculated cross sections for antiproton-hydrogen atom collisions.

physics.atom-ph↗
arXiv2008

A simple parameter-free one-center model potential for an effective one-electron description of molecular hydrogen

For the description of an H2 molecule an effective one-electron model potential is proposed which is fully determined by the exact ionization potential of the H2 molecule. In order to test the model potential and examine its properties it is employed to determine excitation energies, transition moments, and oscillator strengths in a range of the internuclear distances, 0.8 < R < 2.5 a.u. In addition, it is used as a description of an H2 target in calculations of the cross sections for photoionization and for partial excitation in collisions with singly-charged ions. The comparison of the results obtained with the model potential with literature data for H2 molecules yields a good agreement and encourages therefore an extended usage of the potential in various other applications or in order to consider the importance of two-electron and anisotropy effects.

physics.chem-ph↗
arXiv2008

Antiproton collisions with molecular hydrogen

Theoretical antiproton and proton cross sections for ionization and excitation of hydrogen molecules as well as energy spectra of the ionized electrons were calculated in the impact-energy range from 8 to 4000 keV. The cross sections were computed with the close-coupling formulation of the semi-classical impact-parameter method. The target was described using a one-active electron model centered on the target and assuming a fixed internuclear distance during the collision process. The dependence of the ionization cross sections on the internuclear distance is examined. The present cross sections are compared with experimental and theoretical data from the literature. For impact energies E > 90 keV the obtained results for ionization by antiproton impact are comparable to the experimental data while they disagree for energies E < 80 keV.

physics.atom-ph↗
arXiv2008

Antiproton and proton collisions with the alkali metal atoms Li, Na, and K

Single-electron ionization and excitation cross sections as well as cross sections for excitation into the first excited p state of the alkali metal atoms Li(2s), Na(3s) and K(4s) colliding with antiprotons and protons were calculated using a time-dependent channel-coupling approach. For antiprotons an impact-energy range from 0.25 to 1000 keV and for protons from 2 to 1000 keV was considered. The target atoms are treated as effective one-electron systems using a model potential. The results are compared with theoretical and experimental data from literature and calculated cross sections for antiproton-hydrogen collisions. For proton collisions a good overall agreement is found which confirms the present numerical approach, whereas discrepancies are found between the present antiproton cross sections and those calculated by Stary et al., J.Phys.B 23, 263 (1990).

physics.atom-ph↗
arXiv2006

Resonances of the helium atom in a strong magnetic field

We present an investigation on the resonances of a doubly excited helium atom in a strong magnetic field covering the regime B = 0-100 a.u. A full-interaction approach which is based on an anisotropic Gaussian basis set of one-particle functions being nonlinearly optimized for each field strength is employed. Accurate results for a total of 17 resonances below the threshold of consisting of He+ in the N=2 state are reported in this work. This includes states with total magnetic quantum numbers M=0,-1,-2 and even z-parity. The corresponding binding energies are compared to approximate energies of two-particle configurations consisting of two hydrogen-like electrons in the strong field regime, thereby providing an understanding of the behavior of the energies of the resonances with varying field strength.

physics.atom-ph↗