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Arnaud Debussche

Publications and source records attributed to Arnaud Debussche.

At least 37 records · Page 2Linked to original sources

Push-forward method for piecewise deterministic biochemical simulations

A biochemical network can be simulated by a set of ordinary differential equations (ODE) under well stirred reactor conditions, for large numbers of molecules, and frequent reactions. This is no longer a robust representation when some molecular species are in small numbers and reactions changing them are infrequent. In this case, discrete stochastic events trigger changes of the smooth deterministic dynamics of the biochemical network. Piecewise-deterministic Markov processes (PDMP) are well adapted for describing such situations. Although PDMP models are now well established in biology, these models remain computationally challenging. Previously we have introduced the push-forward method to compute how the probability measure is spread by the deterministic ODE flow of PDMPs, through the use of analytic expressions of the corresponding semigroup. In this paper we provide a more general simulation algorithm that works also for non-integrable systems. The method can be used for biochemical simulations with applications in fundamental biology, biotechnology and biocomputing.This work is an extended version of the work presented at the conference CMSB2019.

q-bio.QM↗

Two dimensional Gross-Pitaevskii equation with space-time white noise

In this paper we consider the two-dimensional stochastic Gross-Pitaevskii equation, which is a model to describe Bose-Einstein condensation at positive temperature. The equation is a complex Ginzburg-Landau equation with a harmonic potential and an additive space-time white noise. We study the well-posedness of the model using an inhomogeneous Wick renormalization due to the potential, and prove the existence of an invariant measure and of stationary martingale solutions.

math.PR↗

A Piecewise Deterministic Limit for a Multiscale Stochastic Spatial Gene Network

We consider multiscale stochastic spatial gene networks involving chemical reactions and diffusions. The model is Markovian and the transitions are driven by Poisson random clocks. We consider a case where there are two different spatial scales: a microscopic one with fast dynamic and a macroscopic one with slow dynamic. At the microscopic level, the species are abundant and for the large population limit a partial differential equation (PDE) is obtained. On the contrary at the macroscopic level, the species are not abundant and their dynamic remains governed by jump processes. It results that the PDE governing the fast dynamic contains coefficients which randomly change. The global weak limit is an infinite dimensional continuous piecewise deterministic Markov process (PDMP). Also, we prove convergence in the supremum norm.

math.PR↗

Existence of martingale solutions for stochastic flocking models with local alignment

We establish the existence of martingale solutions to a class of stochastic conservation equations. The underlying models correspond to random perturbations of kinetic models for collective motion such as the Cucker-Smale and Motsch-Tadmor models. By regularizing the coefficients, we first construct approximate solutions obtained as the mean-field limit of the corresponding particle systems. We then establish the compactness in law of this family of solutions by relying on a stochastic averaging lemma. This extends the results obtained by Karper, Mellet and Trivisa in the deterministic case.

math.PR↗

The Boltzmann equation with an external force on the torus: Incompressible Navier-Stokes-Fourier hydrodynamical limit

We study the Boltzmann equation with external forces, not necessarily deriving from a potential, in the incompressible Navier-Stokes perturbative regime. On the torus, we establish local-in-time, for any time, Cauchy theories that are independent of the Knudsen number in Sobolev spaces. The existence is proved around a time-dependent Maxwellian that behaves like the global equilibrium both as time grows and as the Knudsen number decreases. We combine hypocoercive properties of linearized Boltzmann operators with linearization around a time-dependent Maxwellian that catches the fluctuations of the characteristics trajectories due to the presence of the force. This uniform theory is sufficiently robust to derive the incompressible Navier-Stokes-Fourier system with an external force from the Boltzmann equation. Neither smallness, nor time-decaying assumption is required for the external force, nor a gradient form, and we deal with general hard potential and cut-off Boltzmann kernels. As a by-product the latest general theories for unit Knudsen number when the force is sufficiently small and decays in time are recovered.

math-ph↗

Diffusion-approximation for a kinetic spray-like system with random forcing

We study a kinetic toy model for a spray of particles immersed in an ambient fluid, subject to some additional random forcing given by a mixing, space-dependent Markov process. Using the perturbed test function method, we derive the hydrodynamic limit of the kinetic system. The law of the limiting density satisfies a stochastic conservation equation in Stratonovich form, whose drift and diffusion coefficients are completely determined by the law of the stationary process associated with the Markovian perturbation.

math.AP↗

Diffusion-approximation in stochastically forced kinetic equations

We derive the hydrodynamic limit of a kinetic equation where the interactions in velocity are modelled by a linear operator (Fokker-Planck or Linear Boltzmann) and the force in the Vlasov term is a stochastic process with high amplitude and short-range correlation. In the scales and the regime we consider, the hydrodynamic equation is a scalar second-order stochastic partial differential equation. Compared to the deterministic case, we also observe a phenomenon of enhanced diffusion.

math.AP↗

Quasi-Invariance of Gaussian Measures Transported by the Cubic NLS with Third-Order Dispersion on $\mathbf{T}$

We consider the Nonlinear Schrödinger (NLS) equation and prove that the Gaussian measure with covariance $(1-\partial_x^2)^{-α}$ on $L^2(\mathbf T)$ is quasi-invariant for the associated flow for $α>1/2$. This is sharp and improves a previous result obtained in \cite{OTT} where the values $α>3/4$ were obtained. Also, our method is completely different and simpler, it is based on an explicit formula for the Radon-Nikodym derivative. We obtain an explicit formula for this latter in the same spirit as in \cite{Cruz1} and \cite{Cruz2}. The arguments are general and can be used to other Hamiltonian equations.

math.AP↗

Kolmogorov Equations and Weak Order Analysis for SPDES with Nonlinear Diffusion Coefficient

We provide new regularity results for the solutions of the Kolmogorov equation associated to a SPDE with nonlinear diffusion coefficients and a Burgers type nonlinearity. This generalizes previous results in the simpler cases of additive or affine noise. The basic tool is a discrete version of a two sided stochastic integral which allows a new formulation for the derivatives of these solutions. We show that this can be used to generalize the weak order analysis performed in [16]. The tools we develop are very general and can be used to study many other examples of applications.

math.PR↗

A Law of Large Numbers in the Supremum Norm for a Multiscale Stochastic Spatial Gene Network

We study the asymptotic behavior of multiscale stochastic spatial gene networks. Multiscaling takes into account the difference of abundance between molecules , and captures the dynamic of rare species at a mesoscopic level. We introduce an assumption of spatial correlations for reactions involving rare species and a new law of large numbers is obtained. According to the scales, the whole system splits into two parts with different but coupled dynamics. The high scale component converges to the usual spatial model which is the solution of a partial differential equation, whereas, the low scale component converges to the usual homogeneous model which is the solution of an ordinary differential equation. Comparisons are made in the supremum norm.

math.AP↗

Long time behavior of Gross-Pitaevskii equation at positive temperature

The stochastic Gross-Pitaevskii equation is used as a model to describe Bose-Einstein condensation at positive temperature. The equation is a complex Ginzburg Landau equation with a trapping potential and an additive space-time white noise. Two important questions for this system are the global existence of solutions in the support of the Gibbs measure, and the convergence of those solutions to the equilibrium for large time. In this paper, we give a proof of these two results in one space dimension. In order to prove the convergence to equilibrium, we use the associated purely dissipative equation as an auxiliary equation, for which the convergence may be obtained using standard techniques. Global existence is obtained for all initial data, and not almost surely with respect to the invariant measure.

math.AP↗

Solution to the stochastic Schrödinger equation on the full space

We here show how the methods recently applied by [DW16] to solve the stochastic nonlinear Schrödinger equation on $\mathbb{T}^2$ can be enhanced to yield solutions on $\mathbb{R}^2$ if the non-linearity is weak enough. We prove that the solutions remains localized on compact time intervals which allows us to apply energy methods on the full space.

math.PR↗

Large deviations for the dynamic $Φ^{2n}_d$ model

We are dealing with the validity of a large deviation principle for a class of reaction-diffusion equations with polynomial nonlinearity, perturbed by a Gaussian random forcing. We are here interested in the regime where both the strength of the noise and its correlation are vanishing, on a length scale $ε$ and $δ(ε)$, respectively, with $0<ε,δ(ε)<<1$. We prove that, under the assumption that $ε$ and $δ(ε)$ satisfy a suitable scaling limit, a large deviation principle holds in the space of continuous trajectories with values both in the space of square-integrable functions and in Sobolev spaces of negative exponent. Our result is valid, without any restriction on the degree of the polynomial nor on the space dimension.

math.PR↗

The Schr{ö}dinger equation with spatial white noise potential

We consider the linear and nonlinear Schr{ö}dinger equation with a spatial white noise as a potential in dimension 2. We prove existence and uniqueness of solutions thanks to a change of unknown originally used in [8] and conserved quantities.

math.AP↗

Quasilinear generalized parabolic Anderson model equation

We present in this note a local in time well-posedness result for the singular $2$-dimensional quasilinear generalized parabolic Anderson model equation $$ \partial_t u - a(u)Δu = g(u)ξ$$ The key idea of our approach is a simple transformation of the equation which allows to treat the problem as a semilinear problem. The analysis is done within the elementary setting of paracontrolled calculus.

math.AP↗

Degenerate parabolic stochastic partial differential equations: Quasilinear case

In this paper, we study the Cauchy problem for a quasilinear degenerate parabolic stochastic partial differential equation driven by a cylindrical Wiener process. In particular, we adapt the notion of kinetic formulation and kinetic solution and develop a well-posedness theory that includes also an $L^1$-contraction property. In comparison to the previous works of the authors concerning stochastic hyperbolic conservation laws [J. Funct. Anal. 259 (2010) 1014-1042] and semilinear degenerate parabolic SPDEs [Stochastic Process. Appl. 123 (2013) 4294-4336], the present result contains two new ingredients that provide simpler and more effective method of the proof: a generalized Itô formula that permits a rigorous derivation of the kinetic formulation even in the case of weak solutions of certain nondegenerate approximations and a direct proof of strong convergence of these approximations to the desired kinetic solution of the degenerate problem.

math.AP↗

Large deviations for the two-dimensional stochastic Navier-Stokes equation with vanishing noise correlation

We are dealing with the validity of a large deviation principle for the two-dimensional Navier-Stokes equation, with periodic boundary conditions, perturbed by a Gaussian random forcing. We are here interested in the regime where both the strength of the noise and its correlation are vanishing, on a length scale $\e$ and $\d(\e)$, respectively, with $0<\e,\ \d(\e)<<1$. Depending on the relationship between $\e$ and $\d(\e)$ we will prove the validity of the large deviation principle in different functional spaces.

math.PR↗

An integral inequality for the invariant measure of a stochastic reaction--diffusion equation

We consider a reaction--diffusion equation perturbed by noise (not necessarily white). We prove an integral inequality for the invariant measure $ν$ of a stochastic reaction--diffusion equation. Then we discuss some consequences as an integration by parts formula which extends to $ν$ a basic identity of the Malliavin Calculus. Finally, we prove the existence of a surface measure for a ball and a half-space of $H$.

math.PR↗