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Ashley Mehra

Publications and source records attributed to Ashley Mehra.

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Vaccination Worldwide: Strategies, Distribution and Challenges

The Coronavirus 2019 (Covid-19) pandemic caused by the SARS-CoV-2 virus represents an unprecedented crisis for our planet. It is a bane of the \"uber connected world that we live in that this virus has affected almost all countries and caused mortality and economic upheaval at a scale whose effects are going to be felt for generations to come. While we can all be buoyed at the pace at which vaccines have been developed and brought to market, there are still challenges ahead for all countries to get their populations vaccinated equitably and effectively. This paper provides an overview of ongoing immunization efforts in various countries. In this early draft, we have identified a few key factors that we use to review different countries' current COVID-19 immunization strategies and their strengths and draw conclusions so that policymakers worldwide can learn from them. Our paper focuses on processes related to vaccine approval, allocation and prioritization, distribution strategies, population to vaccine ratio, vaccination governance, accessibility and use of digital solutions, and government policies. The statistics and numbers are dated as per the draft date [June 24th, 2021].

q-bio.PE

COVID-19 Tests Gone Rogue: Privacy, Efficacy, Mismanagement and Misunderstandings

COVID-19 testing, the cornerstone for effective screening and identification of COVID-19 cases, remains paramount as an intervention tool to curb the spread of COVID-19 both at local and national levels. However, the speed at which the pandemic struck and the response was rolled out, the widespread impact on healthcare infrastructure, the lack of sufficient preparation within the public health system, and the complexity of the crisis led to utter confusion among test-takers. Invasion of privacy remains a crucial concern. The user experience of test takers remains low. User friction affects user behavior and discourages participation in testing programs. Test efficacy has been overstated. Test results are poorly understood resulting in inappropriate follow-up recommendations. Herein, we review the current landscape of COVID-19 testing, identify four key challenges, and discuss the consequences of the failure to address these challenges. The current infrastructure around testing and information propagation is highly privacy-invasive and does not leverage scalable digital components. In this work, we discuss challenges complicating the existing covid-19 testing ecosystem and highlight the need to improve the testing experience for the user and reduce privacy invasions. Digital tools will play a critical role in resolving these challenges.

cs.CY

Digital Landscape of COVID-19 Testing: Challenges and Opportunities

The COVID-19 Pandemic has left a devastating trail all over the world, in terms of loss of lives, economic decline, travel restrictions, trade deficit, and collapsing economy including real-estate, job loss, loss of health benefits, the decline in quality of access to care and services and overall quality of life. Immunization from the anticipated vaccines will not be the stand-alone guideline that will help surpass the pandemic and return to normalcy. Four pillars of effective public health intervention include diagnostic testing for both asymptomatic and symptomatic individuals, contact tracing, quarantine of individuals with symptoms or who are exposed to COVID-19, and maintaining strict hygiene standards at the individual and community level. Digital technology, currently being used for COVID-19 testing include certain mobile apps, web dashboards, and online self-assessment tools. Herein, we look into various digital solutions adapted by communities across universities, businesses, and other organizations. We summarize the challenges experienced using these tools in terms of quality of information, privacy, and user-centric issues. Despite numerous digital solutions available and being developed, many vary in terms of information being shared in terms of both quality and quantity, which can be overwhelming to the users. Understanding the testing landscape through a digital lens will give a clear insight into the multiple challenges that we face including data privacy, cost, and miscommunication. It is the destiny of digitalization to navigate testing for COVID-19. Block-chain based systems can be used for privacy preservation and ensuring ownership of the data to remain with the user. Another solution involves having digital health passports with relevant and correct information. In this early draft, we summarize the challenges and propose possible solutions to address the same.

cs.CY

Challenges of Equitable Vaccine Distribution in the COVID-19 Pandemic

The COVID-19 pandemic has led to a need for widespread and rapid vaccine development. As several vaccines have recently been approved for human use or are in different stages of development, governments across the world are preparing comprehensive guidelines for vaccine distribution and monitoring. In this early article, we identify challenges in logistics, health outcomes, user-centric matters, and communication associated with disease-related, individual, societal, economic, and privacy consequences. Primary challenges include difficulty in equitable distribution, vaccine efficacy, duration of immunity, multi-dose adherence, and privacy-focused record-keeping to be HIPAA compliant. While many of these challenges have been previously identified and addressed, some have not been acknowledged from a comprehensive view accounting for unprecedented interactions between challenges and specific populations. The logistics of equitable widespread vaccine distribution in disparate populations and countries of various economic, racial, and cultural constitutions must be thoroughly examined and accounted for. We also describe unique challenges regarding the efficacy of vaccines in specialized populations including children, the elderly, and immunocompromised individuals. Furthermore, we report the potential for understudied drug-vaccine interactions as well as the possibility that certain vaccine platforms may increase susceptibility to HIV. Given these complicated issues, the importance of privacy-focused, user-centric systems for vaccine education and incentivization along with clear communication from governments, organizations, and academic institutions is imperative. These challenges are by no means insurmountable, but require careful attention to avoid consequences spanning a range of disease-related, individual, societal, economic, and security domains.

econ.GN

COVID-19 Contact-Tracing Mobile Apps: Evaluation and Assessment for Decision Makers

A number of groups, from governments to non-profits, have quickly acted to innovate the contact-tracing process: they are designing, building, and launching contact-tracing apps in response to the COVID-19 crisis. A diverse range of approaches exist, creating challenging choices for officials looking to implement contact-tracing technology in their community and raising concerns about these choices among citizens asked to participate in contact tracing. We are frequently asked how to evaluate and differentiate between the options for contact-tracing applications. Here, we share the questions we ask about app features and plans when reviewing the many contact-tracing apps appearing on the global stage.

cs.CY