OCT-FedSIR: Toward Trustworthy Federated Ophthalmic Learning under Annotation Noise
Federated learning enables collaborative model development without centralizing patient data, but annotation reliability at participating institutions cannot always be assumed. In ophthalmic imaging, differences in disease prevalence and class composition can resemble changes caused by corrupted supervision. We introduce OCT-FedSIR, a reliability-aware spectral framework for federated OCT classification under client-dependent annotation noise and heterogeneous data distributions. OCT-FedSIR combines class-balanced spectral estimation, Stage-I logit adjustment, complementary spectral descriptors, selective spectral relabeling, and noise-aware federated optimization. We evaluated the framework on the Kermany, University of Illinois Chicago, and Wake Forest datasets under symmetric and structured asymmetric noise and three levels of non-IID heterogeneity. Across 117 experimental conditions, OCT-FedSIR achieved a mean accuracy of 86.73%, compared with 79.94% for RoFL and 78.75% for FedCorr. It correctly separated clients with original and corrupted annotations across all evaluated conditions, while the original FedSIR identification procedure was less robust, particularly under asymmetric noise. Spectral relabeling recovered 77.2% of corrupted annotations with 91.3% correction precision and a 3.5% false-correction rate. Retaining corrected clients outperformed spectral pruning by 9.30 percentage points on average. These findings show that annotation noise can often be identified and corrected without discarding informative client data.