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Ava Khamseh

Publications and source records attributed to Ava Khamseh.

12 recordsLinked to original sources

The Born Ultimatum: Conditions for Classical Surrogation of Quantum Generative Models with Correlators

Quantum Circuit Born Machines (QCBMs) are powerful quantum generative models that sample according to the Born rule, with complexity-theoretic evidence suggesting potential quantum advantages for generative tasks. Here, we identify QCBMs as a quantum Fourier model independently of the loss function. This allows us to apply known dequantization conditions when the optimal quantum distribution is available. However, realizing this distribution is hindered by trainability issues such as vanishing gradients on quantum hardware. Recent train-classical, deploy-quantum approaches propose training classical surrogates of QCBMs and using quantum devices only for inference. We analyze the limitations of these methods arising from deployment discrepancies between classically trained and quantumly deployed parameters. Using the Fourier decomposition of the Born rule in terms of correlators, we quantify this discrepancy analytically. Approximating the decomposition via distribution truncation and classical surrogation provides concrete examples of such discrepancies, which we demonstrate numerically. We study this effect using tensor-networks and Pauli-propagation-based classical surrogates. Our study examines the use of IQP circuits, matchcircuits, Heisenberg-chain circuits, and Haldane-chain circuits for the QCBM ansatz. In doing so, we derive closed-form expressions for Pauli propagation in IQP circuits and the dynamical Lie algebra of the Haldane chain, which may be of independent interest.

quant-ph

Semi-parametric efficient estimation of small genetic effects in large-scale population cohorts

Population genetics seeks to quantify DNA variant associations with traits or diseases, as well as interactions among variants and with environmental factors. Computing millions of estimates in large cohorts in which small effect sizes are expected, necessitates minimising model-misspecification bias to control false discoveries. We present TarGene, a unified statistical workflow for the semi-parametric efficient and double robust estimation of genetic effects including k-point interactions among categorical variables in the presence of confounding and weak population dependence. k-point interactions, or Average Interaction Effects (AIEs), are a direct generalisation of the usual average treatment effect (ATE). We estimate AIEs with cross-validated and/or weighted versions of Targeted Minimum Loss-based Estimators (TMLE) and One-Step Estimators (OSE). The effect of dependence among data units on variance estimates is corrected by using sieve plateau variance estimators based on genetic relatedness across the units. We present extensive realistic simulations to demonstrate power, coverage, and control of type I error. Our motivating application is the targeted estimation of genetic effects on trait, including two-point and higher-order gene-gene and gene-environment interactions, in large-scale genomic databases such as UK Biobank and All of Us. All cross-validated and/or weighted TMLE and OSE for the AIE k-point interaction, as well as ATEs, conditional ATEs and functions thereof, are implemented in the general purpose Julia package TMLE.jl. For high-throughput applications in population genomics, we provide the open-source Nextflow pipeline and software TarGene which integrates seamlessly with modern high-performance and cloud computing platforms.

stat.AP

Higher-order interactions in statistical physics and machine learning: A model-independent solution to the inverse problem at equilibrium

The problem of inferring pair-wise and higher-order interactions in complex systems involving large numbers of interacting variables, from observational data, is fundamental to many fields. Known to the statistical physics community as the inverse problem, it has become accessible in recent years due to real and simulated 'big' data being generated. Current approaches to the inverse problem rely on parametric assumptions, physical approximations, e.g. mean-field theory, and ignoring higher-order interactions which may lead to biased or incorrect estimates. We bypass these shortcomings using a cross-disciplinary approach and demonstrate that none of these assumptions and approximations are necessary: We introduce a universal, model-independent, and fundamentally unbiased estimator of all-order symmetric interactions, via the non-parametric framework of Targeted Learning, a subfield of mathematical statistics. Due to its universality, our definition is readily applicable to any system at equilibrium with binary and categorical variables, be it magnetic spins, nodes in a neural network, or protein networks in biology. Our approach is targeted, not requiring fitting unnecessary parameters. Instead, it expends all data on estimating interactions, hence substantially increasing accuracy. We demonstrate the generality of our technique both analytically and numerically on (i) the 2-dimensional Ising model, (ii) an Ising-like model with 4-point interactions, (iii) the Restricted Boltzmann Machine, and (iv) simulated individual-level human DNA variants and representative traits. The latter demonstrates the applicability of this approach to discover epistatic interactions causal of disease in population biomedicine.

stat.ME

Beyond the Standard Model Kaon Mixing with Physical Masses

We present results from a calculation of beyond the standard model (BSM) kaon mixing including data physical with light quark masses. We simulate $N_f=2+1$ QCD with Iwasaki gauge and domain wall fermion action on 8 ensembles, spanning 3 lattice spacings and pion masses from the physical value up to 430MeV. The ratio of the BSM to standard model (SM) matrix elements are extracted from the correlation functions and renormalised using the RI-SMOM Rome-Southampton method with non-exceptional kinematics. The results at the physical point continuum limit are found by performing a simultaneous continuum chiral extrapolation. In this work we gain consistency with our previous results and achieve a reduction in both the statistical and systematic error.

hep-lat

Machine learning determination of dynamical parameters: The Ising model case

We train a set of Restricted Boltzmann Machines (RBMs) on one- and two-dimensional Ising spin configurations at various values of temperature, generated using Monte Carlo simulations. We validate the training procedure by monitoring several estimators, including measurements of the log-likelihood, with the corresponding partition functions estimated using annealed importance sampling. The effects of various choices of hyper-parameters on training the RBM are discussed in detail, with a generic prescription provided. Finally, we present a closed form expression for extracting the values of couplings, for every $n$-point interaction between the visible nodes of an RBM, in a binary system such as the Ising model. We aim at using this study as the foundation for further investigations of less well-known systems.

physics.comp-ph

BSM Kaon Mixing at the Physical Point

We present a progress update on the calculation of beyond the standard model (BSM) kaon mixing matrix elements at the physical point. Simulations are performed using 2+1 flavour domain wall lattice QCD with the Iwasaki gauge action at 3 lattice spacings and with pion masses ranging from 430 MeV to the physical pion mass.

hep-lat

The decay constants ${\mathbf{f_D}}$ and ${\mathbf{f_{D_{s}}}}$ in the continuum limit of ${\mathbf{N_f=2+1}}$ domain wall lattice QCD

We present results for the decay constants of the $D$ and $D_s$ mesons computed in lattice QCD with $N_f=2+1$ dynamical flavours. The simulations are based on RBC/UKQCD's domain wall ensembles with both physical and unphysical light-quark masses and lattice spacings in the range 0.11--0.07$\,$fm. We employ the domain wall discretisation for all valence quarks. The results in the continuum limit are $f_D=208.7(2.8)_\mathrm{stat}\left(^{+2.1}_{-1.8}\right)_\mathrm{sys}\,\mathrm{MeV}$ and $f_{D_{s}}=246.4(1.3)_\mathrm{stat}\left(^{+1.3}_{-1.9}\right)_\mathrm{sys}\,\mathrm{MeV}$ and $f_{D_s}/f_D=1.1667(77)_\mathrm{stat}\left(^{+57}_{-43}\right)_\mathrm{sys}$. Using these results in a Standard Model analysis we compute the predictions $|V_{cd}|=0.2185(50)_\mathrm{exp}\left(^{+35}_{-37}\right)_\mathrm{lat}$ and $|V_{cs}|=1.011(16)_\mathrm{exp}\left(^{+4}_{-9}\right)_\mathrm{lat}$ for the CKM matrix elements.

hep-lat

Charm Physics with Domain Wall Fermions and Physical Pion Masses

We present RBC/UKQCD's charm project using $N_f=2+1$ flavour ensembles with inverse lattice spacings in the range $1.73-2.77\,\mathrm{GeV}$ and two physical pion mass ensembles. Domain wall fermions are used for the light as well as the charm quarks. We discuss our strategy for the extraction of the decay constants $f_D$ and $f_{D_s}$ and their extrapolation to the continuum limit, physical pion masses and the physical heavy quark mass. Our preliminary results are $f_D=208.7(2.8)\,\mathrm{MeV}$ and $f_{D_s}=246.4(1.9)\,\mathrm{MeV}$ where the quoted error is statistical only. We outline our current approach to extend the reach in the heavy quark mass and present preliminary results.

hep-lat

A massive momentum-subtraction scheme

A new renormalization scheme is defined for fermion bilinears in QCD at non vanishing quark masses. This new scheme, denoted RI/mSMOM, preserves the benefits of the nonexceptional momenta introduced in the RI/SMOM scheme, and allows a definition of renormalized composite fields away from the chiral limit. Some properties of the scheme are investigated by performing explicit one-loop computation in dimensional regularization.

hep-lat

A massive momentum-subtraction scheme

We introduce a new massive renormalization scheme, denoted mSMOM, as a modification of the existing RI/SMOM scheme. We use SMOM for defining renormalized fermion bilinears in QCD at non-vanishing fermion mass. This scheme has properties similar to those of the SMOM scheme, such as the use of non-exceptional symmetric momenta, while in contrast to SMOM, it defines the renormalized fields away from the chiral limit. Here we discuss some of the properties of mSMOM, and present non-perturbative arguments for deriving some renormalization constants. The results of a 1-loop calculation in dimensional regularization are briefly summarised to illustrate some properties of the scheme.

hep-lat

Domain Wall Charm Physics with Physical Pion Masses: Decay constants, bag and $ξ$ parameters

We provide an overview of RBC/UKQCD's charm project on 2+1 flavour physical pion mass ensembles using Möbius Domain Wall Fermions for the light as well as for the charm quark. We discuss the analysis strategy in detail and present results at the different stages of the analysis for $D$ and $D_s$ decay constants as well as the bag and $ξ$ parameters. We also discuss future approaches to extend the reach in the heavy quark mass.

hep-lat

Charm physics with physical light and strange quarks using domain wall fermions

We present a study of charm physics using RBC/UKQCD 2+1 flavour physical point domain wall fermion ensembles for the light quarks as well as for the valence charm quark. After a brief motivation of domain wall fermions as a suitable heavy quark discretisation we will show first results for masses and matrix elements.

hep-lat