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Avneek Sandhu

Publications and source records attributed to Avneek Sandhu.

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Orientation Reading by Production Vision-Language Models on Optotype Charts: A Controlled Multi-Model Evaluation Across Reasoning Modes, Prompts, and Access Modalities

OBJECTIVES: Vision-language models are increasingly used to interpret medical and everyday images through consumer chat interfaces, yet their ability to read orientation - the single perceptual operation tested by the tumbling-E acuity optotype - is poorly characterized on the surfaces through which they are actually used. METHODS: We evaluated four production vision-language models (referred to as Claude, GPT, GROK, and Gemini) through their consumer chat interfaces on a locked set of seven optotype charts: four uniform tumbling-E charts (one per cardinal orientation), two mixed-orientation tumbling-E charts, and one Snellen letter chart as a specificity control. Each model was run in two reasoning modes (Fast and Thinking) under two prompt variants (with and without an explicit orientation-decoding rule) by up to three operators. The corpus comprised 920 scoreable trials and 50,420 glyph judgements. The primary outcome was glyph-level accuracy against the chart's designed orientation, summarized with Wilson 95% confidence intervals. RESULTS: Accuracy ranged from 43.0% to 97.0% across models on identical charts, and the strongest model depended on reasoning mode (GPT 97.0% in Fast mode; GROK 96.6% in Thinking mode). Errors were not random but collapsed onto a model-specific attractor direction. Models were 96-100% internally self-consistent yet ranged widely in accuracy, dissociating reliability from validity. An answer-key-free ensemble-consensus estimate tracked accuracy closely (r = 0.998). For one model, consumer-interface accuracy fell 25-27 points below programmatic access, almost entirely on a single orientation. CONCLUSIONS: A single accuracy figure conceals clinically relevant, orientation-specific failure modes; vision-language models should be evaluated along multiple axes and on the deployment surface before image-interpretation outputs are trusted.

q-bio.OT

PROMPT: A Pre-registered Randomized Protocol for Component-Level Evaluation of Clinical AI Prompts

BACKGROUND:Prompt engineering shapes medical AI outcomes, but prompt components are rarely tested as clinical interventions. We developed PROMPT (Pre-registered Randomized Outcome Measurement for Prompt Testing), a protocol using pre-specification, randomization, matched controls, dismantling, and decision rules.METHODS:Two pre-registered demonstrations used Claude Sonnet 4.6. Exp 1 used a synthetic tumbling-E orientation task: 630-trial main study, 480-trial dismantling study, and 1,050-trial 2x2 factorial extension. Exp 2 used the same arms on 16 label-masked CBIS-DDSM mammographic crops in four orientations: 256 confirmatory trials and a 64-trial Arm E extension. Matched controls removed the active component while preserving framing, structure, and output format.RESULTS:PROMPT identified beneficial, inactive, harmful, and task-dependent effects. In Exp 1, the full prompt achieved 98.6% orientation accuracy; removing the decoding rule reduced accuracy to 50.1% (difference, +48.5 pp; 95% CI, +43.2 to +53.7; P<0.001). A rule-only arm matched the full prompt (maximum difference, 2.3 pp), identifying the decoding rule as the sole measurable active component. A prohibited-reasoning block assumed to improve safety was inactive, an effect missed by whole-prompt comparison. Scaffolding without the task-specific rule underperformed the vehicle prompt, showing prompt structure alone was harmful. Exp 1 revealed a canonical-RIGHT error phenotype in no-rule arms, consistent with a RIGHT-orientation prior. In Exp 2, the phenotype recurred on mammographic images, but the rule's benefit was attenuated and did not meet the threshold (+14.1 pp; bootstrap 95% CI, -3.1 to +29.7; post-hoc mixed-model 95% CI, +3.5 to +24.6).CONCLUSION:PROMPT revealed component effects missed by whole-prompt evaluations, identifying safety vulnerabilities and performance failures before clinical AI deployment.

q-bio.OT

Dynamic Computerized Tumbling-E Testing for Temporal Reliability of Human Sequential Perceptual Decisions

OBJECTIVES: Visual acuity and tumbling-E tasks are often treated as static threshold measures, yet sequential perceptual decisions unfold over time. A computerized tumbling-E task preserves response latency, timeouts, and stimulus-size adaptation, creating a temporal reliability dataset rather than only a chart-line score. This matters for human-AI comparison because the Temporal Hallucination Index (THI) shows how static accuracy can obscure delays, drift, persistence, and unstable convergence. METHODS: We curated trial-level human data from a computerized dynamic tumbling-E task. On each trial, a single E optotype appeared in one of four orientations, participants selected the perceived direction or timed out, and stimulus size was automatically adjusted through an adaptive staircase. Primary outcomes were reaction time, timeout rate, delay rate above a 3-second budget, and observable THI based on delay and timeout components. RESULTS: The final dataset included 1,154 valid trials from 21 human identifiers across 77 sessions. There were 1,078 non-timeout responses and 76 timeouts, giving a 6.6% timeout rate. Non-timeout reaction times centered near 1.5 seconds (mean 1546 ms; median 1506 ms; IQR 1306-1713 ms), with only 3 responses exceeding 3,000 ms. Adaptation was dominated by smaller-next-stimulus transitions (89.2%). Mean arcminutes declined from 29.42 at trial 0 to 5.04 at trial 19, supporting convergence near a 20/20-level optotype without clinical acuity diagnosis. CONCLUSIONS: This dataset converts a tumbling-E visual task into a temporally resolved human perceptual-decision benchmark. Its novel contribution is automatic capture of staircase behavior, response timing, timeouts, and trial-level reliability signals. The human data show fast timing and smooth adaptation toward threshold, establishing a human-only baseline for future comparison with artificial agents.

q-bio.NC