Azar Kazemi | Searcharxiv

arXiv2026

Paired Uterine Whole-Slide Images and Pathology Reports for Multimodal Computational Pathology

Uterine diseases represent an important category of gynecologic pathology and require accurate histopathological assessment for diagnosis and treatment planning. Whole-slide images (WSI) have enabled the digital transformation of pathology workflows and provided new opportunities for artificial intelligence (AI) in computational pathology. In particular, multimodal models that jointly analyze histopathology images and pathology reports have shown promising potential for automated pathology report generation and AI-assisted diagnosis. However, the development of such systems remains limited by the scarcity of datasets that pair whole-slide images with clinically meaningful pathology reports. Instead, existing pathology datasets focus on patch- or slide-level annotations of a single endpoint (e.g., disease class), which do not fully capture the rich information in full clinical diagnostic workflow reports. Here, we introduce TUM-Uteria, a uterine pathology dataset comprising WSIs paired with diagnostic pathology reports at both the case and slide levels, collected from a tertiary medical center. The dataset contains 216 clinical cases, comprising 455 slide-level WSI-report pairs. The dataset underwent a structured multi-stage validation procedure involving board-certified pathologists to ensure reliable annotations. TUM-Uteria supports research in computational pathology, including whole-slide image analysis, multimodal learning, and automated pathology report generation.

cs.CV↗

arXiv2025

From Pixels to Pathology: Restoration Diffusion for Diagnostic-Consistent Virtual IHC

Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression, such as HER2 status for breast cancer grading, but remains costly and time-consuming, limiting its use in time-sensitive clinical workflows. To address this gap, virtual staining from H&E to IHC has emerged as a promising alternative, yet faces two core challenges: (1) Lack of fair evaluation of synthetic images against misaligned IHC ground truths, and (2) preserving structural integrity and biological variability during translation. To this end, we present an end-to-end framework encompassing both generation and evaluation in this work. We introduce Star-Diff, a structure-aware staining restoration diffusion model that reformulates virtual staining as an image restoration task. By combining residual and noise-based generation pathways, Star-Diff maintains tissue structure while modeling realistic biomarker variability. To evaluate the diagnostic consistency of the generated IHC patches, we propose the Semantic Fidelity Score (SFS), a clinical-grading-task-driven metric that quantifies class-wise semantic degradation based on biomarker classification accuracy. Unlike pixel-level metrics such as SSIM and PSNR, SFS remains robust under spatial misalignment and classifier uncertainty. Experiments on the BCI dataset demonstrate that Star-Diff achieves state-of-the-art (SOTA) performance in both visual fidelity and diagnostic relevance. With rapid inference and strong clinical alignment,it presents a practical solution for applications such as intraoperative virtual IHC synthesis.

eess.IV↗