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Benjamin Judkewitz

Publications and source records attributed to Benjamin Judkewitz.

7 recordsLinked to original sources

Privacy-Preserving Epidemiological Modeling on Mobile Graphs

The latest pandemic COVID-19 brought governments worldwide to use various containment measures to control its spread, such as contact tracing, social distance regulations, and curfews. Epidemiological simulations are commonly used to assess the impact of those policies before they are implemented. Unfortunately, the scarcity of relevant empirical data, specifically detailed social contact graphs, hampered their predictive accuracy. As this data is inherently privacy-critical, a method is urgently needed to perform powerful epidemiological simulations on real-world contact graphs without disclosing any sensitive~information. In this work, we present RIPPLE, a privacy-preserving epidemiological modeling framework enabling standard models for infectious disease on a population's real contact graph while keeping all contact information locally on the participants' devices. As a building block of independent interest, we present PIR-SUM, a novel extension to private information retrieval for secure download of element sums from a database. Our protocols are supported by a proof-of-concept implementation, demonstrating a 2-week simulation over half a million participants completed in 7 minutes, with each participant communicating less than 50 KB.

cs.CR

Kilohertz binary phase modulator for pulsed laser sources using a digital micromirror device

The controlled modulation of an optical wavefront is required for aberration correction, digital phase conjugation or patterned photostimulation. For most of these applications it is desirable to control the wavefront modulation at the highest rates possible. The digital micromirror device (DMD) presents a cost-effective solution to achieve high-speed modulation and often exceeds the speed of the more conventional liquid crystal spatial light modulator, but is inherently an amplitude modulator. Furthermore, spatial dispersion caused by DMD diffraction complicates its use with pulsed laser sources, such as those used in nonlinear microscopy. Here we introduce a DMD-based optical design that overcomes these limitations and achieves dispersion-free high-speed binary phase modulation. We show that this phase modulation can be used to switch through binary phase patterns at the rate of 20 kHz in two-photon excitation fluorescence applications.

physics.ins-det

Convolutional neural networks that teach microscopes how to image

Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to resolve with a standard optical microscope. Here, we use a convolutional neural network (CNN) not only to classify images, but also to optimize the physical layout of the imaging device itself. We increase the classification accuracy of a microscope's recorded images by merging an optical model of image formation into the pipeline of a CNN. The resulting network simultaneously determines an ideal illumination arrangement to highlight important sample features during image acquisition, along with a set of convolutional weights to classify the detected images post-capture. We demonstrate our joint optimization technique with an experimental microscope configuration that automatically identifies malaria-infected cells with 5-10% higher accuracy than standard and alternative microscope lighting designs.

cs.CV

Scattering correlations of time-gated light

Manipulating the propagation of light through scattering media remains a major challenge for many applications, including astronomy, biomedical imaging and colloidal optics. Wavefront shaping is one of the most promising ways to mitigate scattering and focus through inhomogeneous samples. However, wavefront correction remains accurate over only a limited spatial extent within the scattering medium - a correlation range referred to as the optical memory effect. Here, by selecting only the weakly scattered light for wavefront shaping, we show that the addition of temporal degrees of freedom enhances this correlation range. We investigate spatial scattering correlations by digitally time-gating the early arriving light in the spectral domain. We demonstrate that the range of the translational memory effect for the early arriving light is increased almost fourfold, paving the way for a range of scattering media imaging applications.

physics.optics

The generalized optical memory effect

The optical memory effect is a well-known type of wave correlation that is observed in coherent fields that scatter through thin and diffusive materials, like biological tissue. It is a fundamental physical property of scattering media that can be harnessed for deep-tissue microscopy or 'through-the-wall' imaging applications. Here we show that the optical memory effect is a special case of a far more general class of wave correlation. Our new theoretical framework explains how waves remain correlated over both space and angle when they are jointly shifted and tilted inside scattering media of arbitrary geometry. We experimentally demonstrate the existence of such coupled correlations and describe how they can be used to optimize the scanning range in adaptive optics microscopes.

physics.optics

Translation correlations in anisotropically scattering media

Controlling light propagation across scattering media by wavefront shaping holds great promise for a wide range of communications and imaging applications. However, finding the right wavefront to shape is a challenge when the mapping between input and output scattered wavefronts (i.e. the transmission matrix) is not known. Correlations in transmission matrices, especially the so-called memory-effect, have been exploited to address this limitation. However, the traditional memory-effect applies to thin scattering layers at a distance from the target, which precludes its use within thick scattering media, such as fog and biological tissue. Here, we theoretically predict and experimentally verify new transmission matrix correlations within thick anisotropically scattering media, with important implications for biomedical imaging and adaptive optics.

physics.optics

Physical key-protected one-time pad

We describe an encrypted communication principle that can form a perfectly secure link between two parties without electronically saving either of their keys. Instead, cryptographic key bits are kept safe within the unique mesoscopic randomness of two volumetric scattering materials. We demonstrate how a shared set of patterned optical probes can generate 10 gigabits of statistically verified randomness between a pair of unique 2 cubic millimeter scattering objects. This shared randomness is used to facilitate information-theoretically secure communication following a modified one-time pad protocol. Benefits of volumetric physical storage over electronic memory include the inability to probe, duplicate or selectively reset any random bits without fundamentally altering the entire key space. Beyond the demonstrated communication scheme, our ability to securely couple the randomness contained within two unique physical objects may help strengthen the hardware for a large class of cryptographic protocols, which is currently a critically weak link in the security pipeline of our increasingly mobile communication culture.

physics.optics