Benjamin Sanchez | Searcharxiv

arXiv2026

A wearable electrical hemodynamic imaging ring

Continuous ambulatory monitoring of peripheral vascular perfusion could enable earlier detection of vascular dysfunction in individuals with diabetes mellitus and more timely management of cardiovascular disease. Clinical imaging modalities provide high-fidelity vascular information but are impractical for ambulatory use, whereas most wearable devices are limited to single-modality sensing and do not provide imaging. Electrical bioimpedance has the potential to bridge this gap by enabling rapid spatial and temporal imaging while remaining sensitive to hemodynamic changes. Here, we introduce a wearable ring with 8 electrodes and 32-channel bioimpedance sensing for finger blood flow imaging. In 96 healthy participants measured at rest and during autonomic maneuvers, we resolve conductivity images in the digital arteries associated with pulsatile blood flow and train neural network models for continuous cuffless blood pressure waveform estimation. We demonstrate the feasibility of bioimpedance imaging in a ring form factor, supporting its potential for ambulatory cuffless hemodynamic monitoring.

physics.med-ph↗

arXiv2025

Cuffless, calibration-free hemodynamic monitoring with physics-informed machine learning models

Wearable technologies have the potential to transform ambulatory and at-home hemodynamic monitoring by providing continuous assessments of cardiovascular health metrics and guiding clinical management. However, existing cuffless wearable devices for blood pressure (BP) monitoring often rely on methods lacking theoretical foundations, such as pulse wave analysis or pulse arrival time, making them vulnerable to physiological and experimental confounders that undermine their accuracy and clinical utility. Here, we developed a smartwatch device with real-time electrical bioimpedance (BioZ) sensing for cuffless hemodynamic monitoring. We elucidate the biophysical relationship between BioZ and BP via a multiscale analytical and computational modeling framework, and identify physiological, anatomical, and experimental parameters that influence the pulsatile BioZ signal at the wrist. A signal-tagged physics-informed neural network incorporating fluid dynamics principles enables calibration-free estimation of BP and radial and axial blood velocity. We successfully tested our approach with healthy individuals at rest and after physical activity including physical and autonomic challenges, and with patients with hypertension and cardiovascular disease in outpatient and intensive care settings. Our findings demonstrate the feasibility of BioZ technology for cuffless BP and blood velocity monitoring, addressing critical limitations of existing cuffless technologies.

physics.med-ph↗