arXiv subjects

Benjamin Steinegger

Publications and source records attributed to Benjamin Steinegger.

6 recordsLinked to original sources

arXiv2021

Homophily impacts the success of vaccine roll-outs

Physical contacts do not occur randomly, rather, individuals with similar socio-demographic and behavioural characteristics are more likely to interact among them, a phenomenon known as homophily. Concurrently, the same characteristics correlate with the adoption of prophylactic tools. As a result, the latter do not unfold homogeneously in a population, affecting their ability to control the spread of infectious diseases. Here, focusing on the case of vaccines, we reveal three different dynamical regimes as a function of the mixing rate between vaccinated and non vaccinated individuals. Specifically, depending on the epidemic pressure, vaccine coverage and efficacy, we find the attack rate to decrease, increase or vary non monotonously with respect to the mixing rate. We corroborate the phenomenology through Monte Carlo simulations on a temporal physical contact network. Besides vaccines, our findings hold for a wide range of prophylactic tools, indicating a universal mechanism in spreading dynamics

physics.soc-ph↗

arXiv2021

The impact of homophily on digital proximity tracing

We study how homophily of human physical interactions affects the efficacy of digital proximity tracing. Analytical results show a non monotonous dependence of the reproduction number with respect to the mixing rate between individuals that adopt the contact tracing app and the ones that do not. Furthermore, we find regimes in which the attack rate has local optima, minima or monotonously varies with the mixing rate. We corroborate our findings with Monte Carlo simulations on a primary-school network. This study provides a mathematical basis to better understand how homophily in health behavior shapes the dynamics of epidemics.

physics.soc-ph↗

arXiv2021

Virus spread versus contact tracing: two competing contagion processes

After the blockade that many nations suffered to stop the growth of the incidence curve of COVID-19 during the first half of 2020, they face the challenge of resuming their social and economic activity. The rapid airborne transmissibility of SARS-CoV-2, and the absence of a vaccine, calls for active containment measures to avoid the propagation of transmission chains. The best strategy up to date, popularly known as Test-Track-Treat (TTT), consist in testing the population for diagnosis, track the contacts of those infected, and treat by quarantine all these cases. The dynamical process that better describes the combined action of the former mechanisms is that of a contagion process that competes with the spread of the pathogen, cutting off potential contagion pathways. Here we propose a compartmental model that couples the dynamics of the infection with the contact tracing and isolation of cases. We develop an analytical expression for the effective case reproduction number $R_c(t)$ that reveals the role of contact tracing in the mitigation and suppression of the epidemics. We show that there is a trade off between the infection propagation and the isolation of cases. If the isolation is limited to symptomatic individuals only, the incidence curve can be flattened but not bended. However, if contact tracing is applied to asymptomatic individuals too, the strategy can bend the curve and suppress the epidemics. Quantitative results are dependent on the network topology. We quantify, the most important indicator of the effectiveness of contact tracing, namely its capacity to reverse the increasing tendency of the epidemic curve, causing its bending.

physics.soc-ph↗

arXiv2020

Pulsating-campaigns of human prophylaxis driven by risk perception palliate oscillations of direct contact transmitted diseases

Human behavioral responses play an important role in the impact of disease outbreaks and yet they are often overlooked in epidemiological models. Understanding to what extent behavioral changes determine the outcome of spreading epidemics is essential to design effective intervention policies. Here we explore, analytically, the interplay between the personal decision to protect oneself from infection and the spreading of an epidemic. We do so by coupling a decision game based on the perceived risk of infection with a Susceptible-Infected-Susceptible model. Interestingly, we find that the simple decision on whether to protect oneself is enough to modify the course of the epidemics, by generating sustained steady oscillations in the prevalence. We deem these oscillations detrimental, and propose two intervention policies aimed at modifying behavioral patterns to help alleviate them. Surprisingly, we find that pulsating campaigns, compared to continuous ones, are more effective in diminishing such oscillations.

physics.soc-ph↗

arXiv2019

Evaluating the impact of PrEP on HIV and gonorrhea on a networked population of female sex workers

Sexual contacts are the main spreading route of HIV. This puts sex workers at higher risk of infection even in populations where HIV prevalence is moderate or low. Alongside condom use, Pre-Exposure Prophylaxis (PrEP) is an effective tool for sex workers to reduce their risk of HIV acquisition. However, PrEP provides no direct protection against sexually transmitted infections (STIs) other than HIV, unlike condoms. We use an empirical network of sexual contacts among female sex workers (FSWs) and clients to simulate the spread of HIV and gonorrhea. We then investigate the effect of PrEP adoption and adherence, on both HIV and gonorrhea prevalence. We also study the effect of a potential increase in condomless acts due to lowered risk perception with respect of the no-PrEP scenario (risk compensation). We find that when HIV is the only disease circulating, PrEP is effective in reducing HIV prevalence, even with high risk compensation. Instead, the complex interplay between the two diseases shows that different levels of risk compensation require different intervention strategies. Finally, we find that providing PrEP only to the most active FSWs is less effective than uniform PrEP adoption. Our work shows that the effects emerging from the complex interactions between these diseases and the available prophylactic measures need to be accounted for, to devise effective intervention strategies.

physics.soc-ph↗

arXiv2018

Interplay between cost and benefits triggers nontrivial vaccination uptake

The containment of epidemic spreading is a major challenge in science. Vaccination, whenever available, is the best way to prevent the spreading, because it eventually immunizes individuals. However, vaccines are not perfect, and total immunization is not guaranteed. Imperfect immunization has driven the emergence of anti-vaccine movements that totally alter the predictions about the epidemic incidence. Here, we propose a mathematically solvable mean-field vaccination model to mimic the spontaneous adoption of vaccines against influenza-like diseases, and the expected epidemic incidence. The results are in agreement with extensive Monte Carlo simulations of the epidemics and vaccination co-evolutionary processes. Interestingly, the results reveal a non-monotonic behavior on the vaccination coverage, that increases with the imperfection of the vaccine and after decreases. This apparent counterintuitive behavior is analyzed and understood from stability principles of the proposed mathematical model.

physics.soc-ph↗