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Benoît Perthame

Publications and source records attributed to Benoît Perthame.

At least 19 recordsLinked to original sources

Deriving subdiffusion equations from general Renewal--Jump dynamics

Subdiffusion occurs when long trapping or residence times of particles slow down spatial transport and produce a mean squared displacement proportional to $t^\alpha$, with~$0<\alpha<1$. We develop a general renewal--jump framework that combines the internal trapping dynamics with the reinjection of particles with spatial jumps. The internal trapping dynamics enters the macroscopic limit through the small-frequency behavior of a resolvent which limiting solution is not integrable. A growth mass condition determines the parameter~$\alpha$. Then the spatial density converges on the time scale~$\eps^{-2/\alpha}$ to a time-fractional diffusion equation. This criterion provides a common derivation for models with very different internal mechanisms. We first establish the abstract limit by Laplace transform in a general setting. We then show that the classical age-structured renewal model is a direct instance of the framework and apply the same criterion to an internal pathway model governed by a degenerate elliptic operator. Both yield the subdiffusion equation and its correct initial condition. The approach clarifies which microscopic property produces subdiffusion, how the anomalous exponent determines the macroscopic scaling, and why the initial distribution enters the limit through the initial spatial mass under the stated preparation assumptions.

math.AP

A stiff limit of non-homogeneous conservation laws for crowd motion modeling

We propose a new approach for crowd motion models where the density constraint can only slow down the motion of each agent, with no effect on those agents who are not in a saturated area or who have no saturated density ''in front'' of them. This is done by means of a limit of conservation laws inspired by the equations used for traffic as in Follow the leader-type models. We study the asymptotics of the solutions of these conservation laws in a certain asymptotic regime, and obtain a PDE at the limit of a whole new type. One of the main goals of the paper is to prove uniform BV estimates on the density, and thus strong compactness to prove the existence of solutions to this limit equation. We also discuss the qualitative behavior of solutions, provide numerical illustrations both in dimension 1 and 2, and establish the new entropy inequalities associated with this limit equation.

math.AP

A Fokker-Planck equation with superlinear drift at infinity for Integrate-and-Fire model

The Integrate-and-Fire model is a Fokker-Planck equation arising in neuroscience. It describes the evolution of the probability density of the neuronal membrane potential and fitting has shown that the inclusion of a em superlinear drift provides the most realistic description. To make sense of this, we propose to set the equation on the full line, the neural activity being described by the flux at infinity. This framework serves as a model extension of the classical Noisy Integrate-and-Fire model, with a fixed firing potential. We first establish the well-posedness of the solution, establish the boundary condition at infinity which is the major difficulty. Then, state rigorously the entropy dissipation property. Finally, using Doeblin's method, we prove the exponential convergence of the solution toward the unique stationary state in full generality.

math.AP

Multiscale analysis of a kinetic equation for mechanotaxis

We present a new kinetic equation for cell migration driven by mechanical interactions with the substrate, an effect not previously captured in kinetic models, and essential for explaining observed collective behaviors such as those in bacterial colonies. The model introduces an acceleration term that accounts for the dynamics of motile cells undergoing mechanotaxis, where extracellular signals modulate the forces arising from cell-substrate interactions. From this formulation, we derive a family of macroscopic limit equations and analyze their principal properties. In particular, we examine linear stability and pattern formation ability through theoretical analysis, supported by numerical simulations.

math.AP

On a relaxed Cahn-Hilliard tumour growth model with single-well potential and degenerate mobility

We consider a phase-field system modelling solid tumour growth. This system consists of a Cahn-Hilliard equation coupled with a nutrient equation. The former is characterised by a degenerate mobility and a singular potential. Both equations are subject to suitable reaction terms which model proliferation and nutrient consumption. Chemotactic effects are also taken into account. Adding an elliptic regularisation, depending on a relaxation parameter $\delta>0$, in the equation for the chemical potential, we prove the existence of a weak solution to an initial and boundary value problem for the relaxed system. Then, we let $\delta$ go to zero, and we recover the existence of a weak solution to the original system.

math.AP

Monge-Kantorovich distance for PDEs: the coupling method

We informally review a few PDEs for which the Monge-Kantorovich distance between pairs of solutions, possibly with some judicious cost function, decays: heat equation, Fokker-Planck equation, heat equation with varying coefficients, fractional heat equation with varying coefficients, homogeneous Boltzmann equation for Maxwell molecules, and some nonlinear integro-differential equations arising in neurosciences. We always use the same method, that consists in building a coupling between two solutions. This amounts to solve a well-chosen PDE posed on the Euclidian square of the physical space, i.e. doubling the variables. Finally, although the above method fails, we recall a simple idea to treat the case of the porous media equation. We also introduce another method based on the dual Monge-Kantorovich problem.

math.AP

Deriving sub-diffusion equations

Sub-diffusion equations are used in a large range of applications including fluids, plasma physics and biology. Their mathematical analysis is advanced even if a much larger literature addresses super-diffusions. The goal of this paper is to provide the microscopic mechanism and rigorous derivation of sub-diffusions when the waiting time distribution of particles follows an age-structured equation and jumps occur at each renewal. The major difficulty to recover sub-diffusions, unlike normal diffusions, is that the assumption of long waiting time implies lack of integrability for the age equilibrium. This prevents to establish strong a priori estimates. Here, the Laplace transform plays the role that Fourier transform plays for the more traditional case of fast diffusions.

math.AP

Strongly nonlinear age structured equation,time-elapsed model and large delays

The time-elapsed model for neural networks is a nonlinear age structured equationwhere the renewal term describes the network activity and influences the dischargerate, possibly with a delay due to the length of connections.We solve a long standing question, namely that an inhibitory network withoutdelay will converge to a steady state and thus the network is desynchonised. Ourapproach is based on the observation that a non-expansion property holds true.However a non-degeneracy condition is needed and, besides the standard one, weintroduce a new condition based on strict nonlinearity.When a delay is included, and following previous works for Fokker-Planck models,we prove that the network may generate periodic solutions. We introduce a newformalism to establish rigorously this property for large delays.The fundamental contraction property also holds for some other age structuredequations and systems.

math.AP

Noisy integrate-and-fire equation: continuation after blow-up

The integrate and fire equation is a classical model for neural assemblies which can exhibit finite time blow-up. A major open problem is to understand how to continue solutions after blow-up. Here we study an approach based on random discharge models and a change of time which generates a classical global solution to the expense of a strong absorption rate 1/$ε$. We prove that in the limit $ε$ $\rightarrow$ 0 + , a global solution is recovered where the integrate and fire equation is reformulated with a singular measure. This describes the dynamics after blow-up and also gives information on the blow-up phenomena itself.The major difficulty is to handle nonlinear terms. To circumvent it, we establish two new estimates, a kind of equi-integrability of the discharge measure and a L 2 estimate of the density. The use of the new timescale turns out to be fundamental for those estimates.

math.AP

A model for membrane degradation using a gelatin invadopodia assay

One of the most crucial and lethal characteristics of solid tumors is represented by the increased ability of cancer cells to migrate and invade other organs during the so-called metastatic spread. This is allowed thanks to the production of matrix metalloproteinases (MMPs), enzymes capable of degrading a type of collagen abundant in the basal membrane separating the epithelial tissue from the connective one. In this work, we employ a synergistic experimental and mathematical modelling approach to explore the invasion process of tumor cells. A athematical model composed of reaction-diffusion equations describing the evolution of the tumor cells density on a gelatin substrate, MMPs enzymes concentration and the degradation of the gelatin is proposed. This is completed with a calibration strategy. We perform a sensitivity analysis and explore a parameter estimation technique both on synthetic and experimental data in order to find the optimal parameters that describe the in vitro experiments. A comparison between numerical and experimental solutions ends the work.

q-bio.TO

Wasserstein contraction for the stochastic Morris-Lecar neuron model

Neuron models have attracted a lot of attention recently, both in mathematics and neuroscience. We are interested in studying long-time and large-population emerging properties in a simplified toy model. From a mathematical perspective, this amounts to study the long-time behaviour of a degenerate reflected diffusion process. Using coupling arguments, the flow is proven to be a contraction of the Wasserstein distance for long times, which implies the exponential relaxation toward a (non-explicit) unique globally attractive equilibrium distribution. The result is extended to a McKean-Vlasov type non-linear variation of the model, when the mean-field interaction is sufficiently small. The ergodicity of the process results from a combination of deterministic contraction properties and local diffusion, the noise being sufficient to drive the system away from non-contractive domains.

math.PR

Incompressible limit of porous media equation with chemotaxis and growth

We revisit the problem of proving the incompressible limit for the compressible porous media equation with Newtonian drift and growth. The question is motivated by models of living tissues development including chemotaxis. We extend the problem, already treated by the authors and several other contributions, in using a simplified approach, in treating dimensions two or higher, and in incorporating the pressure driven growth term. We also complete the analysis with stronger $L^4$ estimates on the pressure gradient. The major difficulty is to prove the strong convergence of the pressure gradient which is obtained here by a new observation on an algebraic relation involving the pressure gradient for weak limits.

math.AP

On the limit problem arising in the kinetic derivation of the Cahn-Hilliard equation

The non-local degenerate Cahn-Hilliard equation is derived from the Vlasov equation with long-range attraction. We study the local limit as the delocalization parameter converges to 0. The difficulty arises from the degeneracy which requires compactness estimates, but all necessary a priori estimates can be obtained only on the nonlocal quantities yielding almost no information on the limiting solution itself. We introduce a novel condition on the nonlocal kernel which allows us to exploit the available nonlocal a priori estimates. The condition, satisfied by most of the kernels appearing in the applications, can be of independent interest. Our approach is flexible and systems can be treated as well.

math.AP

Nonlocal Cahn-Hilliard equation with degenerate mobility: Incompressible limit and convergence to stationary states

The link between compressible models of tissue growth and the Hele-Shaw free boundary problem of fluid mechanics has recently attracted a lot of attention. In most of these models, only repulsive forces and advection terms are taken into account. In order to take into account long range interactions, we include for the first time a surface tension effect by adding a nonlocal term which leads to the degenerate nonlocal Cahn-Hilliard equation, and study the incompressible limit of the system. The degeneracy and the source term are the main difficulties. Our approach relies on a new L^infty estimate obtained by De Giorgi iterations and on a uniform control of the energy despite the source term. We also prove the long-term convergence to a single constant stationary state of any weak solution using entropy methods, even when a source term is present. Our result shows that the surface tension in the nonlocal (and even local) Cahn-Hilliard equation will not prevent the tumor from completely invading the domain.

math.AP

An infinite-times renewal equation

In neuroscience, the time elapsed since the last discharge has been used to predict the probability of the next discharge. Such predictions can be improved taking into account the last two discharge times, and possibly more. Such multi-time processes arise in many other areas and there is no universal limitation on the number of times to be used. This observation leads us to study the infinite-times renewal equation as a simple model to understand the meaning and properties of such partial differential equations depending on an infinite number of variables.We define two notions of solutions, prove existence and uniqueness of solutions, possibly measures. We also prove the long time convergence, with exponential rate, to the steady state in different, strong or weak, topologies depending on assumptions on the coefficients.

math.AP

Final size and convergence rate for an epidemic in heterogeneous population

We formulate a general SEIR epidemic model in a heterogenous population characterized by some trait in a discrete or continuous subset of a space R d. The incubation and recovery rates governing the evolution of each homogenous subpopulation depend upon this trait, and no restriction is assumed on the contact matrix that defines the probability for an individual of a given trait to be infected by an individual with another trait. Our goal is to derive and study the final size equation fulfilled by the limit distribution of the population. We show that this limit exists and satisfies the final size equation. The main contribution is to prove the uniqueness of this solution among the distributions smaller than the initial condition. We also establish that the dominant eigenvalue of the next-generation operator (whose initial value is equal to the basic reproduction number) decreases along every trajectory until a limit smaller than 1. The results are shown to remain valid in presence of diffusion term. They generalize previous works corresponding to finite number of traits (including metapopulation models) or to rank 1 contact matrix (modeling e.g. susceptibility or infectivity presenting heterogeneity independently of one another).

math.AP

Incompressible limits of Patlak-Keller-Segel model and its stationary state

We complete previous results about the incompressible limit of both the $n$-dimensional $(n\geq3)$ compressible Patlak-Keller-Segel (PKS) model and its stationary state. As in previous works, in this limit, we derive the weak form of a geometric free boundary problem of Hele-Shaw type, also called congested flow. In particular, we are able to take into account the unsaturated zone, and establish the complementarity relation which describes the limit pressure by a degenerate elliptic equation. Not only our analysis uses a completely different framework than previous approaches, but we also establish a novel uniform $L^3$ estimate of the pressure gradient, regularity à la Aronson-Bénilan, and a uniform $L^1$ estimate for the time derivative of the pressure. Furthermore, for the Hele-Shaw problem, we prove the uniqueness of solutions, meaning that the incompressible limit of the PKS model is unique. In addition, we establish the corresponding incompressible limit of the stationary state for the PKS model with a given mass, where, different from the case of PKS model, we obtain the uniform bound of pressure and the uniformly bounded support of density.

math.AP

Pressure jump and radial stationary solutions of the degenerate Cahn-Hilliard equation

The Cahn-Hilliard equation with degenerate mobility is used in several areas including the modeling of living tissues. We are interested in quantifying the pressure jump at the interface in the case of incompressible flows. To do so, we include an external force and consider stationary radial solutions. This allows us to compute the pressure jump in the small dispersion regime. We also characterize compactly supported stationary solutions in the incompressible case, prove the incompressible limit and prove convergence of the parabolic problems to stationary states.

math.AP