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Bernhard Preim

Publications and source records attributed to Bernhard Preim.

17 recordsLinked to original sources

FINCH: Locally Visualizing Higher-Order Feature Interactions in Black Box Models

In an era where black-box AI models are integral to decision-making across industries, robust methods for explaining these models are more critical than ever. While these models leverage complex feature interplay for accurate predictions, most explanation methods only assign relevance to individual features. There is a research gap in methods that effectively illustrate interactions between features, especially in visualizing higher-order interactions involving multiple features, which challenge conventional representation methods. To address this challenge in local explanations focused on individual instances, we employ a visual, subset-based approach to reveal relevant feature interactions. Our visual analytics tool FINCH uses coloring and highlighting techniques to create intuitive, human-centered visualizations, and provides additional views that enable users to calibrate their trust in the model and explanations. We demonstrate FINCH in multiple case studies, demonstrating its generalizability, and conducted an extensive human study with machine learning experts to highlight its helpfulness and usability. With this approach, FINCH allows users to visualize feature interactions involving any number of features locally.

cs.HC

Visualization of Age Distributions as Elements of Medical Data-Stories

In various fields, including medicine, age distributions are crucial. Despite widespread media coverage of health topics, there remains a need to enhance health communication. Narrative medical visualization is promising for improving information comprehension and retention. This study explores the most effective ways to present age distributions of diseases through narrative visualizations. We conducted a thorough analysis of existing visualizations, held workshops with a broad audience, and reviewed relevant literature. From this, we identified design choices focusing on comprehension, aesthetics, engagement, and memorability. We specifically tested three pictogram variants: pictograms as bars, stacked pictograms, and annotations. After evaluating 18 visualizations with 72 participants and three expert reviews, we determined that annotations were most effective for comprehension and aesthetics. However, traditional bar charts were preferred for engagement, and other variants were more memorable. The study provides a set of design recommendations based on these insights.

cs.HC

Enhancing Uncertainty Communication in Time Series Predictions: Insights and Recommendations

As the world increasingly relies on mathematical models for forecasts in different areas, effective communication of uncertainty in time series predictions is important for informed decision making. This study explores how users estimate probabilistic uncertainty in time series predictions under different variants of line charts depicting uncertainty. It examines the role of individual characteristics and the influence of user-reported metrics on uncertainty estimations. By addressing these aspects, this paper aims to enhance the understanding of uncertainty visualization and for improving communication in time series forecast visualizations and the design of prediction data dashboards.As the world increasingly relies on mathematical models for forecasts in different areas, effective communication of uncertainty in time series predictions is important for informed decision making. This study explores how users estimate probabilistic uncertainty in time series predictions under different variants of line charts depicting uncertainty. It examines the role of individual characteristics and the influence of user-reported metrics on uncertainty estimations. By addressing these aspects, this paper aims to enhance the understanding of uncertainty visualization and for improving communication in time series forecast visualizations and the design of prediction data dashboards.

cs.HC

Expert exploranation for communicating scientific methods -- A case study in conflict research

Science communication aims at making key research insights accessible to the broad public. If explanatory and exploratory visualization techniques are combined to do so, the approach is also referred to as exploranation. In this context, the audience is usually not required to have domain expertise. However, we show that exploranation can not only support the communication between researchers and a broad audience, but also between researchers directly. With the goal of communicating an existing method for conducting causal inference on spatio-temporal conflict event data, we investigated how to perform exploranation for experts, i.e., expert exploranation. Based on application scenarios of the inference method, we developed three versions of an interactive visual story to explain the method to conflict researchers. We abstracted the corresponding design process and evaluated the stories both with experts who were unfamiliar with the explained method and experts who were already familiar with it. The positive and extensive feedback from the evaluation shows that expert exploranation is a promising direction for visual storytelling, as it can help to improve scientific outreach, methodological understanding, and accessibility for researchers new to a field.

cs.CY

Surgical Phase and Instrument Recognition: How to identify appropriate Dataset Splits

Purpose: Machine learning models can only be reliably evaluated if training, validation, and test data splits are representative and not affected by the absence of classes of interest. Surgical workflow and instrument recognition tasks are complicated in this manner, because of heavy data imbalances resulting from different lengths of phases and their erratic occurrences. Furthermore, the issue becomes difficult as sub-properties that help define phases, like instrument (co-)occurrence, are usually not considered when defining the split. We argue that such sub-properties must be equally considered. Methods: This work presents a publicly available data visualization tool that enables interactive exploration of dataset splits for surgical phase and instrument recognition. It focuses on the visualization of the occurrence of phases, phase transitions, instruments, and instrument combinations across sets. Particularly, it facilitates the assessment and identification of sub-optimal dataset splits. Results: We performed an analysis of common Cholec80 dataset splits using the proposed application and were able to uncover phase transitions and combinations of instruments that were not represented in one of the sets. Additionally, we outlined possible improvements to the splits. A user study with ten participants demonstrated the ability of participants to solve a selection of data exploration tasks using the proposed application. Conclusion: In highly unbalanced class distributions, special care should be taken with respect to the selection of an appropriate dataset split. Our interactive data visualization tool presents a promising approach for the assessment of dataset splits for surgical phase and instrument recognition. Evaluation results show that it can enhance the development of machine learning models. The application is available at https://cardio-ai.github.io/endovis-ml/ .

cs.LG

Enhancing Vascular Analysis with Distance Visualizations: An Overview and Implementation

In recent years, the use of expressive surface visualizations in the representation of vascular structures has gained significant attention. These visualizations provide a comprehensive understanding of complex anatomical structures and are crucial for treatment planning and medical education. However, to aid decision-making, physicians require visualizations that accurately depict anatomical structures and their spatial relationships in a clear and well-perceivable manner. This work extends a previous paper and presents a thorough examination of common techniques for encoding distance information of 3D vessel surfaces and provides an implementation of these visualizations. A Unity environment and detailed implementation instructions for sixteen different visualizations are provided. These visualizations can be classified into four categories: fundamental, surface-based, auxiliary, and illustrative. Furthermore, this extension includes tools to generate endpoint locations for vascular models. Overall this framework serves as a valuable resource for researchers in the field of vascular surface visualization by reducing the barrier to entry and promoting further research in this area. By providing an implementation of various visualizations, this paper aims to aid in the development of accurate and effective visual representations of vascular structures to assist in treatment planning and medical education.

cs.GR

Narrative Visualization to Communicate Neurological Diseases

While narrative visualization has been used successfully in various applications to communicate scientific data in the format of a story to a general audience, the same has not been true for medical data. There are only a few exceptions that present tabular medical data to non-experts. However, a key component of medical visualization is the interactive analysis of 3D data, such as 3D models of anatomical structures, which were rarely included in narrative visualizations so far. In this design study, we investigate how neurological disease data can be communicated through narrative visualization techniques to a general audience in an understandable way. We designed a narrative visualization explaining cerebral small vessel disease. Learning about its avoidable risk factors serves to motivate the audience watching the resulting visual data story. Using this example, we discuss the adaption of basic narrative components. This includes the conflict and characters of a story, as well as the story's structure and content to address and communicate specific characteristics of medical data. Furthermore, we explore the extent to which complex medical relationships need to be simplified to be understandable to a general audience without distorting the underlying data and evidence. In particular, the data needs to be preprocessed for non-experts and appropriate forms of interaction must be found. We explore approaches to make the data more personally relatable, such as including a fictional patient. We evaluated our approach in a user study with 40 participants in a web-based implementation of the designed story. We found that the combination of a carefully thought-out storyline with a clear key message, appealing visualizations combined with easy-to-use interactions, and credible references are crucial for creating a narrative visualization about a neurological disease that engages an audience.

cs.HC

Towards Narrative Medical Visualization

Narrative visualization aims to communicate scientific results to a general audience and garners significant attention in various applications. Merging exploratory and explanatory visualization could effectively support a non-expert understanding of scientific processes. Medical research results, e.g., mechanisms of the healthy human body, explanations of pathological processes, or avoidable risk factors for diseases, are also interesting to a general audience that includes patients and their relatives. This paper discusses how narrative techniques can be applied to medical visualization to tell data-driven stories about diseases. We address the general public comprising people interested in medicine without specific medical background knowledge. We derived a general template for the narrative medical visualization of diseases. Applying this template to three diseases selected to span bone, vascular, and organ systems, we discuss how narrative techniques can support visual communication and facilitate understanding of medical data. Other scientists can adapt our proposed template to inform an audience on other diseases. With our work, we show the potential of narrative medical visualization and conclude with a comprehensive research agenda.

cs.CY

Student and Teacher Meet in a Shared Virtual Reality: A one-on-one Tutoring System for Anatomy Education

We introduce a Virtual Reality (VR) one-on-one tutoring system to support anatomy education. A student uses a fully immersive VR headset to explore the anatomy of the base of the human skull. A teacher guides the student by using the semi-immersive zSpace. Both systems are connected via network and each action is synchronized between both systems. The teacher is provided with various features to direct the student through the immersive learning experience. She can influence the student's navigation or provide annotations on the fly and, hereby, improve the students learning experience. The system is implemented using the \textit{Unity} game engine. A qualitative user study demonstrates that the one-on-one tutoring approach is feasible and sets a solid base for future research in the area of shared virtual environments for anatomy education.

cs.HC

Cardiac Cohort Classification based on Morphologic and Hemodynamic Parameters extracted from 4D PC-MRI Data

An accurate assessment of the cardiovascular system and prediction of cardiovascular diseases (CVDs) are crucial. Measured cardiac blood flow data provide insights about patient-specific hemodynamics, where many specialized techniques have been developed for the visual exploration of such data sets to better understand the influence of morphological and hemodynamic conditions on CVDs. However, there is a lack of machine learning approaches techniques that allow a feature-based classification of heart-healthy people and patients with CVDs. In this work, we investigate the potential of morphological and hemodynamic characteristics, extracted from measured blood flow data in the aorta, for the classification of heart-healthy volunteers and patients with bicuspid aortic valve (BAV). Furthermore, we research if there are characteristic features to classify male and female as well as older heart-healthy volunteers and BAV patients. We propose a data analysis pipeline for the classification of the cardiac status, encompassing feature selection, model training and hyperparameter tuning. In our experiments, we use several feature selection methods and classification algorithms to train separate models for the healthy subgroups and BAV patients. We report on classification performance and investigate the predictive power of morphological and hemodynamic features with regard to the classification of the defined groups. Finally, we identify the key features for the best models.

cs.LG

MedMeshCNN -- Enabling MeshCNN for Medical Surface Models

Background and objective: MeshCNN is a recently proposed Deep Learning framework that drew attention due to its direct operation on irregular, non-uniform 3D meshes. On selected benchmarking datasets, it outperformed state-of-the-art methods within classification and segmentation tasks. Especially, the medical domain provides a large amount of complex 3D surface models that may benefit from processing with MeshCNN. However, several limitations prevent outstanding performances of MeshCNN on highly diverse medical surface models. Within this work, we propose MedMeshCNN as an expansion for complex, diverse, and fine-grained medical data. Methods: MedMeshCNN follows the functionality of MeshCNN with a significantly increased memory efficiency that allows retaining patient-specific properties during the segmentation process. Furthermore, it enables the segmentation of pathological structures that often come with highly imbalanced class distributions. Results: We tested the performance of MedMeshCNN on a complex part segmentation task of intracranial aneurysms and their surrounding vessel structures and reached a mean Intersection over Union of 63.24\%. The pathological aneurysm is segmented with an Intersection over Union of 71.4\%. Conclusions: These results demonstrate that MedMeshCNN enables the application of MeshCNN on complex, fine-grained medical surface meshes. The imbalanced class distribution deriving from the pathological finding is considered by MedMeshCNN and patient-specific properties are mostly retained during the segmentation process.

cs.CV

Flexible and Comprehensive Patient-Specific Mitral Valve Silicone Models with Chordae Tendinae Made From 3D-Printable Molds

Given the multitude of challenges surgeons face during mitral valve repair surgery, they should have a high confidence in handling of instruments and in the application of surgical techniques before they enter the operating room. Unfortunately, opportunities for surgical training of minimally-invasive repair are very limited, leading to a situation where most surgeons undergo a steep learning curve while operating the first patients. In order to provide a realistic tool for surgical training, a commercial simulator was augmented by flexible patient-specific mitral valve replica. In an elaborated production pipeline, finalized after many optimization cycles, models were segmented from 3D ultrasound and then 3D-printable molds were computed automatically and printed in rigid material, the lower part being water-soluble. After silicone injection, the silicone model was dissolved from the mold and anchored in the simulator. To our knowledge, our models are the first to comprise the full mitral valve apparatus, i.e. the annulus, leaflets, chordae tendineae and papillary muscles. Nine different valve molds were automatically created according to the proposed workflow (seven prolapsed valves and two valves with functional mitral insufficiency). From these mold geometries, 16 replica were manufactured. A material test revealed that Ecoflex\textsuperscript{TM} 00-30 is the most suitable material for leaflet-mimicking tissue out of seven mixtures. Production time was around 36h per valve. Twelve surgeons performed various surgical techniques, e.g. annuloplasty, neo-chordae implantation, triangular leaflet resection and assessed the realism of the valves very positively. The standardized production process guarantees a high anatomical recapitulation of the silicone valves to the segmented models and the ultrasound data...

physics.med-ph

Visual Subpopulation Discovery and Validation in Cohort Study Data

Epidemiology aims at identifying subpopulations of cohort participants that share common characteristics (e.g. alcohol consumption) to explain risk factors of diseases in cohort study data. These data contain information about the participants' health status gathered from questionnaires, medical examinations, and image acquisition. Due to the growing volume and heterogeneity of epidemiological data, the discovery of meaningful subpopulations is challenging. Subspace clustering can be leveraged to find subpopulations in large and heterogeneous cohort study datasets. In our collaboration with epidemiologists, we realized their need for a tool to validate discovered subpopulations. For this purpose, identified subpopulations should be searched for independent cohorts to check whether the findings apply there as well. In this paper we describe our interactive Visual Analytics framework S-ADVIsED for SubpopulAtion Discovery and Validation In Epidemiological Data. S-ADVIsED enables epidemiologists to explore and validate findings derived from subspace clustering. We provide a coordinated multiple view system, which includes a summary view of all subpopulations, detail views, and statistical information. Users can assess the quality of subspace clusters by considering different criteria via visualization. Furthermore, intervals for variables involved in a subspace cluster can be adjusted. This extension was suggested by epidemiologists. We investigated the replication of a selected subpopulation with multiple variables in another population by considering different measurements. As a specific result, we observed that study participants exhibiting high liver fat accumulation deviate strongly from other subpopulations and from the total study population with respect to age, body mass index, thyroid volume and thyroid-stimulating hormone.

cs.GR

Feature Lines for Illustrating Medical Surface Models: Mathematical Background and Survey

This paper provides a tutorial and survey for a specific kind of illustrative visualization technique: feature lines. We examine different feature line methods. For this, we provide the differential geometry behind these concepts and adapt this mathematical field to the discrete differential geometry. All discrete differential geometry terms are explained for triangulated surface meshes. These utilities serve as basis for the feature line methods. We provide the reader with all knowledge to re-implement every feature line method. Furthermore, we summarize the methods and suggest a guideline for which kind of surface which feature line algorithm is best suited. Our work is motivated by, but not restricted to, medical and biological surface models.

cs.GR

Visual Analytics of Image-Centric Cohort Studies in Epidemiology

Epidemiology characterizes the influence of causes to disease and health conditions of defined populations. Cohort studies are population-based studies involving usually large numbers of randomly selected individuals and comprising numerous attributes, ranging from self-reported interview data to results from various medical examinations, e.g., blood and urine samples. Since recently, medical imaging has been used as an additional instrument to assess risk factors and potential prognostic information. In this chapter, we discuss such studies and how the evaluation may benefit from visual analytics. Cluster analysis to define groups, reliable image analysis of organs in medical imaging data and shape space exploration to characterize anatomical shapes are among the visual analytics tools that may enable epidemiologists to fully exploit the potential of their huge and complex data. To gain acceptance, visual analytics tools need to complement more classical epidemiologic tools, primarily hypothesis-driven statistical analysis.

cs.CV

Visual Exploration of Simulated and Measured Blood Flow

Morphology of cardiovascular tissue is influenced by the unsteady behavior of the blood flow and vice versa. Therefore, the pathogenesis of several cardiovascular diseases is directly affected by the blood-flow dynamics. Understanding flow behavior is of vital importance to understand the cardiovascular system and potentially harbors a considerable value for both diagnosis and risk assessment. The analysis of hemodynamic characteristics involves qualitative and quantitative inspection of the blood-flow field. Visualization plays an important role in the qualitative exploration, as well as the definition of relevant quantitative measures and its validation. There are two main approaches to obtain information about the blood flow: simulation by computational fluid dynamics, and in-vivo measurements. Although research on blood flow simulation has been performed for decades, many open problems remain concerning accuracy and patient-specific solutions. Possibilities for real measurement of blood flow have recently increased considerably by new developments in magnetic resonance imaging which enable the acquisition of 3D quantitative measurements of blood-flow velocity fields. This chapter presents the visualization challenges for both simulation and real measurements of unsteady blood-flow fields.

cs.GR

From individual to population: Challenges in Medical Visualization

In this paper, we first give a high-level overview of medical visualization development over the past 30 years, focusing on key developments and the trends that they represent. During this discussion, we will refer to a number of key papers that we have also arranged on the medical visualization research timeline. Based on the overview and our observations of the field, we then identify and discuss the medical visualization research challenges that we foresee for the coming decade.

cs.GR