arXiv subjects

Bing Chu

Publications and source records attributed to Bing Chu.

3 recordsLinked to original sources

arXiv2025

A Clinical-grade Universal Foundation Model for Intraoperative Pathology

Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant strides, the lack of large-scale, prospective validation has impeded its routine adoption in surgical workflows. Here, we introduce CRISP, a clinical-grade foundation model developed on over 100,000 frozen sections from eight medical centers, specifically designed to provide Clinical-grade Robust Intraoperative Support for Pathology (CRISP). CRISP was comprehensively evaluated on more than 15,000 intraoperative slides across nearly 100 retrospective diagnostic tasks, including benign-malignant discrimination, key intraoperative decision-making, and pan-cancer detection, etc. The model demonstrated robust generalization across diverse institutions, tumor types, and anatomical sites-including previously unseen sites and rare cancers. In a prospective cohort of over 2,000 patients, CRISP sustained high diagnostic accuracy under real-world conditions, directly informing surgical decisions in 92.6% of cases. Human-AI collaboration further reduced diagnostic workload by 35%, avoided 105 ancillary tests and enhanced detection of micrometastases with 87.5% accuracy. Together, these findings position CRISP as a clinical-grade paradigm for AI-driven intraoperative pathology, bridging computational advances with surgical precision and accelerating the translation of artificial intelligence into routine clinical practice.

cs.LG↗

arXiv2018

Learning to Calibrate Quantum Control Pulses by Iterative Deconvolution

In experimental control of quantum systems, the precision is often hindered by imperfect applied electronics that distort control pulses delivered to target quantum devices. To mitigate such error, the deconvolution method is commonly used for compensating the distortion via an identified convolutional model. However, its effectiveness is limited by model inaccuracies (e.g., imprecise parameters or unmodeled distortion dynamics). In this paper, we propose a learning-based scheme to eliminate the residual calibration error by repeatedly applying the deconvolution operations. The resulting iterative deconvolution method is shown to be able to correct both linear and nonlinear model errors to the highest precision allowed by available finite sampling rates. The calibration error induced by finite sampling rates is also analyzed, from which we propose that the inter-sampling error can be suppressed by actively introducing nonlinear components in the control electronics.

quant-ph↗

arXiv2018

A Data-Driven Gradient Algorithm for High-Precision Quantum Control

In the quest to achieve scalable quantum information processing technologies, gradient-based optimal control algorithms (e.g., GRAPE) are broadly used for implementing high-precision quantum gates, but their performance is often hindered by deterministic or random errors in the system model and the control electronics. In this paper, we show that GRAPE can be taught to be more effective by jointly learning from the design model and the experimental data obtained from process tomography. The resulting data-driven gradient optimization algorithm (d-GRAPE) can in principle correct all deterministic gate errors, with a mild efficiency loss. The d-GRAPE algorithm may become more powerful with broadband controls that involve a large number of control parameters, while other algorithms usually slow down due to the increased size of the search space. These advantages are demonstrated by simulating the implementation of a two-qubit CNOT gate.

quant-ph↗