arXiv subjects

Bing He

Publications and source records attributed to Bing He.

At least 55 records · Page 3Linked to original sources

arXiv2024

A scaling law in optomechanically induced nonlinear oscillation

Stable limit cycle as a stabilized mechanical oscillation is the primary result of the dynamical evolution of an optomechanical system under sufficiently powerful pump. Because this dynamical process is highly nonlinear, it was not clear whether there exists a quantitative law to relate an evolved mechanical oscillation (the limit cycle of the dynamical process) to the given parameters of the fabricated system. Here, by means of the numerical simulations based on nonlinear dynamics, we demonstrate the existence of such quantitative relations that are generally valid to the nonlinear optomechanical processes. These quantitative relations can be summarized to a scaling law that is seemingly similar to those in phase transitions of many-body systems but has very different properties. Such a quantitative law enables one to find the more feasible system parameters for realizing the same or a similar dynamical evolution result, so it will be useful to the relevant experimental researches.

physics.optics↗

arXiv2024

Simultaneous photon and phonon lasing in a two-tone driven optomechanical system

Achieving simultaneous lasing of photons and phonons in optomechanical setups has great potential for applications in quantum information processing, high precision sensing and the design of hybrid photonic-phononic devices. Here, we explore this possibility with an optomechanical system driven by a two-tone field. Whenever the difference between the driving frequencies matches the associated mechanical frequency, the photon and phonon populations are found to achieve steady-state coherent oscillations, demonstrating a dual lasing phenomenon. Such drive-tone resonance condition can synchronize the phases of the photon and phonon fields, which facilitates a robust simultaneous lasing. Here, we provide analytical insights into the joint amplification of the optical and mechanical modes, and further confirm the dual lasing phenomenon by numerically calculating the relevant correlation functions and the power spectrum. Our setup, consisting of a single optomechanical cavity, is simpler than previous realizations of dual lasing and provides a clean picture of the underlying mechanisms. Our work thus paves the way for the development of novel strategies for the optimisation of optomechanical interactions through tailored driving schemes.

quant-ph↗

arXiv2024

Learning the irreversible progression trajectory of Alzheimer's disease

Alzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage such that intervention can be applied before the onset of symptoms. Machine learning (ML) models have been shown effective in predicting the onset of AD. Yet for subjects with follow-up visits, existing techniques for AD classification only aim for accurate group assignment, where the monotonically increasing risk across follow-up visits is usually ignored. Resulted fluctuating risk scores across visits violate the irreversibility of AD, hampering the trustworthiness of models and also providing little value to understanding the disease progression. To address this issue, we propose a novel regularization approach to predict AD longitudinally. Our technique aims to maintain the expected monotonicity of increasing disease risk during progression while preserving expressiveness. Specifically, we introduce a monotonicity constraint that encourages the model to predict disease risk in a consistent and ordered manner across follow-up visits. We evaluate our method using the longitudinal structural MRI and amyloid-PET imaging data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Our model outperforms existing techniques in capturing the progressiveness of disease risk, and at the same time preserves prediction accuracy.

cs.LG↗

arXiv2024

Highly correlated optomechanical oscillations manifested by an anomalous stabilization

Driven by a sufficiently powerful pump laser, a cavity optomechanical system will stabilize in coupled oscillations of its cavity field and mechanical resonator. It was assumed that the oscillation will be continuously magnified upon enhancing the driving laser further. However, based on the nonlinear dynamics of the system, we find that the dynamical behaviors of the system are much more complex than this intuitive picture, especially when it is operated near the blue detuning point by the mechanical resonator's intrinsic frequency. There exists an anomalous stabilization: depending on its intrinsic damping rate and the pump power, the mechanical resonator will metastably stay on one orbit of oscillation after another until it completely stabilizes on the final orbit it can reach. These orbits are consistent with the locked ones with almost fixed oscillation amplitudes, which are realized after the pump power becomes still higher. The oscillatory cavity field is seen to adjust its sidebands following the mechanical frequency shift due to optical spring effect, so that it always drives the mechanical resonator to near those locked orbits once the pump power is over a threshold. In the regimes with such correlation between cavity field sidebands and mechanical oscillation, the system's dynamical attractors are confined on the locked orbits and chaotic motion is also excluded.

physics.optics↗

arXiv2024

Optical frequency combs significantly spanned to broad bandwidths by an optomechanical resonance

Optical frequency comb, as a spectrum made of discrete and equally spaced spectral lines, is a light source with essential applications in modern technology. Cavity optomechanical systems were found to be a feasible candidate for realizing on-chip frequency comb with low repetition rate. However, it was difficult to increase the comb line numbers of this type of frequency combs because the mechanical oscillation amplitude of such system, which determines the frequency comb bandwidth, cannot quickly increase with pump laser power. Here, we develop a new approach to generate broadband optomechanical frequency comb by employing a different mechanism to enhance the mechanical oscillation. Two pump tones with their frequency difference matching the mechanical frequency will drive the system into a self-organized nonlinear resonance and thus tremendously transfer the energy to the mechanical resonator. As a result, more than $10000$ or even more comb lines become available under the pump laser power in the order of milliwatt. A unique feature of the self-organized resonance is the mechanical frequency locking so that, within a certain range of the frequency difference between two drive tones, the distance between comb teeth can be locked by the two drive tones and becomes independent of any change of pump power. This property guarantees a stable repetition rate of the generated frequency comb.

physics.optics↗

arXiv2024

Hierarchical Query Classification in E-commerce Search

E-commerce platforms typically store and structure product information and search data in a hierarchy. Efficiently categorizing user search queries into a similar hierarchical structure is paramount in enhancing user experience on e-commerce platforms as well as news curation and academic research. The significance of this task is amplified when dealing with sensitive query categorization or critical information dissemination, where inaccuracies can lead to considerable negative impacts. The inherent complexity of hierarchical query classification is compounded by two primary challenges: (1) the pronounced class imbalance that skews towards dominant categories, and (2) the inherent brevity and ambiguity of search queries that hinder accurate classification. To address these challenges, we introduce a novel framework that leverages hierarchical information through (i) enhanced representation learning that utilizes the contrastive loss to discern fine-grained instance relationships within the hierarchy, called ''instance hierarchy'', and (ii) a nuanced hierarchical classification loss that attends to the intrinsic label taxonomy, named ''label hierarchy''. Additionally, based on our observation that certain unlabeled queries share typographical similarities with labeled queries, we propose a neighborhood-aware sampling technique to intelligently select these unlabeled queries to boost the classification performance. Extensive experiments demonstrate that our proposed method is better than state-of-the-art (SOTA) on the proprietary Amazon dataset, and comparable to SOTA on the public datasets of Web of Science and RCV1-V2. These results underscore the efficacy of our proposed solution, and pave the path toward the next generation of hierarchy-aware query classification systems.

cs.IR↗

arXiv2024

Corrective or Backfire: Characterizing and Predicting User Response to Social Correction

Online misinformation poses a global risk with harmful implications for society. Ordinary social media users are known to actively reply to misinformation posts with counter-misinformation messages, which is shown to be effective in containing the spread of misinformation. Such a practice is defined as "social correction". Nevertheless, it remains unknown how users respond to social correction in real-world scenarios, especially, will it have a corrective or backfire effect on users. Investigating this research question is pivotal for developing and refining strategies that maximize the efficacy of social correction initiatives. To fill this gap, we conduct an in-depth study to characterize and predict the user response to social correction in a data-driven manner through the lens of X (Formerly Twitter), where the user response is instantiated as the reply that is written toward a counter-misinformation message. Particularly, we first create a novel dataset with 55, 549 triples of misinformation tweets, counter-misinformation replies, and responses to counter-misinformation replies, and then curate a taxonomy to illustrate different kinds of user responses. Next, fine-grained statistical analysis of reply linguistic and engagement features as well as repliers' user attributes is conducted to illustrate the characteristics that are significant in determining whether a reply will have a corrective or backfire effect. Finally, we build a user response prediction model to identify whether a social correction will be corrective, neutral, or have a backfire effect, which achieves a promising F1 score of 0.816. Our work enables stakeholders to monitor and predict user responses effectively, thus guiding the use of social correction to maximize their corrective impact and minimize backfire effects. The code and data is accessible on https://github.com/claws-lab/response-to-social-correction.

cs.SI↗

arXiv2023

Implicit-explicit Integrated Representations for Multi-view Video Compression

With the increasing consumption of 3D displays and virtual reality, multi-view video has become a promising format. However, its high resolution and multi-camera shooting result in a substantial increase in data volume, making storage and transmission a challenging task. To tackle these difficulties, we propose an implicit-explicit integrated representation for multi-view video compression. Specifically, we first use the explicit representation-based 2D video codec to encode one of the source views. Subsequently, we propose employing the implicit neural representation (INR)-based codec to encode the remaining views. The implicit codec takes the time and view index of multi-view video as coordinate inputs and generates the corresponding implicit reconstruction frames.To enhance the compressibility, we introduce a multi-level feature grid embedding and a fully convolutional architecture into the implicit codec. These components facilitate coordinate-feature and feature-RGB mapping, respectively. To further enhance the reconstruction quality from the INR codec, we leverage the high-quality reconstructed frames from the explicit codec to achieve inter-view compensation. Finally, the compensated results are fused with the implicit reconstructions from the INR to obtain the final reconstructed frames. Our proposed framework combines the strengths of both implicit neural representation and explicit 2D codec. Extensive experiments conducted on public datasets demonstrate that the proposed framework can achieve comparable or even superior performance to the latest multi-view video compression standard MIV and other INR-based schemes in terms of view compression and scene modeling.

cs.CV↗

arXiv2023

DNAGPT: A Generalized Pre-trained Tool for Versatile DNA Sequence Analysis Tasks

Pre-trained large language models demonstrate potential in extracting information from DNA sequences, yet adapting to a variety of tasks and data modalities remains a challenge. To address this, we propose DNAGPT, a generalized DNA pre-training model trained on over 200 billion base pairs from all mammals. By enhancing the classic GPT model with a binary classification task (DNA sequence order), a numerical regression task (guanine-cytosine content prediction), and a comprehensive token language, DNAGPT can handle versatile DNA analysis tasks while processing both sequence and numerical data. Our evaluation of genomic signal and region recognition, mRNA abundance regression, and artificial genomes generation tasks demonstrates DNAGPT's superior performance compared to existing models designed for specific downstream tasks, benefiting from pre-training using the newly designed model structure.

q-bio.GN↗

arXiv2023

A Noisy-Label-Learning Formulation for Immune Repertoire Classification and Disease-Associated Immune Receptor Sequence Identification

Immune repertoire classification, a typical multiple instance learning (MIL) problem, is a frontier research topic in computational biology that makes transformative contributions to new vaccines and immune therapies. However, the traditional instance-space MIL, directly assigning bag-level labels to instances, suffers from the massive amount of noisy labels and extremely low witness rate. In this work, we propose a noisy-label-learning formulation to solve the immune repertoire classification task. To remedy the inaccurate supervision of repertoire-level labels for a sequence-level classifier, we design a robust training strategy: The initial labels are smoothed to be asymmetric and are progressively corrected using the model's predictions throughout the training process. Furthermore, two models with the same architecture but different parameter initialization are co-trained simultaneously to remedy the known "confirmation bias" problem in the self-training-like schema. As a result, we obtain accurate sequence-level classification and, subsequently, repertoire-level classification. Experiments on the Cytomegalovirus (CMV) and Cancer datasets demonstrate our method's effectiveness and superior performance on sequence-level and repertoire-level tasks.

cs.LG↗

arXiv2023

Microbiome-derived bile acids contribute to elevated antigenic response and bone erosion in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic, disabling and incurable autoimmune disease. It has been widely recognized that gut microbial dysbiosis is an important contributor to the pathogenesis of RA, although distinct alterations in microbiota have been associated with this disease. Yet, the metabolites that mediate the impacts of the gut microbiome on RA are less well understood. Here, with microbial profiling and non-targeted metabolomics, we revealed profound yet diverse perturbation of the gut microbiome and metabolome in RA patients in a discovery set. In the Bacteroides-dominated RA patients, differentiation of gut microbiome resulted in distinct bile acid profiles compared to healthy subjects. Predominated Bacteroides species expressing BSH and 7a-HSDH increased, leading to elevated secondary bile acid production in this subgroup of RA patients. Reduced serum fibroblast growth factor-19 and dysregulated bile acids were evidence of impaired farnesoid X receptor-mediated signaling in the patients. This gut microbiota-bile acid axis was correlated to ACPA. The patients from the validation sets demonstrated that ACPA-positive patients have more abundant bacteria expressing BSH and 7a-HSDH but less Clostridium scindens expressing 7a-dehydroxylation enzymes, together with dysregulated microbial bile acid metabolism and more severe bone erosion than ACPA-negative ones. Mediation analyses revealed putative causal relationships between the gut microbiome, bile acids, and ACPA-positive RA, supporting a potential causal effect of Bacteroides species in increasing levels of ACPA and bone erosion mediated via disturbing bile acid metabolism. These results provide insights into the role of gut dysbiosis in RA in a manifestation-specific manner, as well as the functions of bile acids in this gut-joint axis, which may be a potential intervention target for precisely controlling RA conditions.

physics.bio-ph↗

arXiv2023

Nonlinear optomechanical resonance entering a self-organized energy transfer pattern

The energy transfer between different subsystems or different vibration modes is always one of the most interested problems in the study of the resonance phenomena in coupled nonlinear dynamical systems. With an optomechanical system operating in the regime of unresolved sideband, where its mechanical frequency is lower than the cavity field damping rate, we illustrate the existence of a special nonlinear resonance phenomenon. This type of previously unknown resonance manifests an organized pattern of the coupled cavity field and mechanical oscillation, so that the cavity field precisely pushes the mechanical oscillator within an appropriate small time window in each mechanical oscillation period and the mechanical energy will increase by a jump of almost fixed amount after each oscillation cycle. The scenario is realized at a resonance point where the frequency difference of two driving fields matches the mechanical frequency of the system, and this condition of drive-frequency match is found to trigger a mechanism to lock the two subsystems of an unresolved-sideband optomechanical system into a highly ordered energy transfer as the above mentioned. Due to a significantly enhanced nonlinearity in the vicinity of the resonance point, optical frequency combs can be generated under pump powers of thousand times lower, as compared to the use of a single-tone driving field for the purpose. An unresolved sideband system under the drives without satisfying the resonance condition also demonstrates other interesting dynamical behaviors. Most of all, by providing a realistic picture for the nonlinear optomechanical dynamics in unresolved sideband regime, our study points to a direction to observe novel dynamical phenomena and realize other applications with the systems of less technical restrictions.

physics.optics↗

arXiv2023

Transfer of quantum states and stationary quantum correlations in a hybrid optomechanical network

We present a systematic study on the effects of dynamical transfer and steady-state synchronization of quantum states in a hybrid optomechanical network, consisting of two cavities with atoms inside and interacting via a common moving mirror (i.e. mechanical oscillator), are studied. It is found that high fidelity transfer of Schrödinger's cat and squeezed states between the cavities modes is possible. Additionally, we show the effect of synchronization of cavity modes in a steady squeezed states at high fidelity realizable by the mechanical oscillator which intermediates the generation, transfer and stabilization of the squeezing. In this framework, we also have studied the generation and evolution of bipartite and tripartite entanglement and found its interconnection to the effects of transfer and synchronization. Particularly, when the transfer occurs at the maximal fidelity, at this instant any entanglement is almost zero, so the modes are disentangled. On the other hand, when the two bosonic modes are synchronized in a squeezed stationary state, then these modes are also entangled. The results found in this study may find their applicability in quantum information and computation technologies, as well in metrology setups, where the squeezed states are essential.

quant-ph↗

arXiv2023

Characterizing and Predicting Social Correction on Twitter

Online misinformation has been a serious threat to public health and society. Social media users are known to reply to misinformation posts with counter-misinformation messages, which have been shown to be effective in curbing the spread of misinformation. This is called social correction. However, the characteristics of tweets that attract social correction versus those that do not remain unknown. To close the gap, we focus on answering the following two research questions: (1) ``Given a tweet, will it be countered by other users?'', and (2) ``If yes, what will be the magnitude of countering it?''. This exploration will help develop mechanisms to guide users' misinformation correction efforts and to measure disparity across users who get corrected. In this work, we first create a novel dataset with 690,047 pairs of misinformation tweets and counter-misinformation replies. Then, stratified analysis of tweet linguistic and engagement features as well as tweet posters' user attributes are conducted to illustrate the factors that are significant in determining whether a tweet will get countered. Finally, predictive classifiers are created to predict the likelihood of a misinformation tweet to get countered and the degree to which that tweet will be countered. The code and data is accessible on https://github.com/claws-lab/social-correction-twitter.

cs.SI↗

arXiv2023

Reinforcement Learning-based Counter-Misinformation Response Generation: A Case Study of COVID-19 Vaccine Misinformation

The spread of online misinformation threatens public health, democracy, and the broader society. While professional fact-checkers form the first line of defense by fact-checking popular false claims, they do not engage directly in conversations with misinformation spreaders. On the other hand, non-expert ordinary users act as eyes-on-the-ground who proactively counter misinformation -- recent research has shown that 96% counter-misinformation responses are made by ordinary users. However, research also found that 2/3 times, these responses are rude and lack evidence. This work seeks to create a counter-misinformation response generation model to empower users to effectively correct misinformation. This objective is challenging due to the absence of datasets containing ground-truth of ideal counter-misinformation responses, and the lack of models that can generate responses backed by communication theories. In this work, we create two novel datasets of misinformation and counter-misinformation response pairs from in-the-wild social media and crowdsourcing from college-educated students. We annotate the collected data to distinguish poor from ideal responses that are factual, polite, and refute misinformation. We propose MisinfoCorrect, a reinforcement learning-based framework that learns to generate counter-misinformation responses for an input misinformation post. The model rewards the generator to increase the politeness, factuality, and refutation attitude while retaining text fluency and relevancy. Quantitative and qualitative evaluation shows that our model outperforms several baselines by generating high-quality counter-responses. This work illustrates the promise of generative text models for social good -- here, to help create a safe and reliable information ecosystem. The code and data is accessible on https://github.com/claws-lab/MisinfoCorrect.

cs.SI↗

arXiv2023

On an expansion formula of Liu

In this paper, we extend an expansion formula of Liu to multiple basic hypergeometric series over the root system $A_{n}.$ The usefulness of Liu's expansion formula in special functions and number theory has been shown by Liu and many others. We first establish a very general multiple expansion formula over the root system $A_{n}$ and then deduce several $A_{n}$ extensions of Liu's expansion formula. From these multiple formulas, we derive two groups of multiple expansion formulas for infinite products. As applications, we deduce an $A_{n}$ Rogers' $\text{}_{6}ϕ_{5}$ summation, an $A_{n}$ extension of Sylvester's identity, some multiple expansion formulas for $(q)_{\infty}^{m},\text{\ensuremath{π_{q}}}$ and $1/π_{q}$, two $A_{n}$ extensions of the Rogers-Fine identity, an $A_{n}$ extension of Liu's extension of Rogers' non-terminating $_{6}ϕ_{5}$ summation, an $A_{n}$ extension of a generalization of Fang's identity and an $A_{n}$ extension of Andrews' expansion formula.

math.CA↗

arXiv2022

ASGARD: A Single-cell Guided pipeline to Aid Repurposing of Drugs

Intercellular heterogeneity is a major obstacle to successful precision medicine. Single-cell RNA sequencing (scRNA-seq) technology has enabled in-depth analysis of intercellular heterogeneity in various diseases. However, its full potential for precision medicine has yet to be reached. Towards this, we propose a new drug recommendation system called: A Single-cell Guided Pipeline to Aid Repurposing of Drugs (ASGARD). ASGARD defines a novel drug score predicting drugs by considering all cell clusters to address the intercellular heterogeneity within each patient. We tested ASGARD on multiple diseases, including breast cancer, acute lymphoblastic leukemia, and coronavirus disease 2019 (COVID-19). On single-drug therapy, ASGARD shows significantly better average accuracy (AUC of 0.92) compared to two other bulk-cell-based drug repurposing methods (AUC of 0.80 and 0.76). It is also considerably better (AUC of 0.82) than other cell cluster level predicting methods (AUC of 0.67 and 0.55). In addition, ASGARD is also validated by the drug response prediction method TRANSACT with Triple-Negative-Breast-Cancer patient samples. Many top-ranked drugs are either approved by FDA or in clinical trials treating corresponding diseases. In silico cell-type specific drop-out experiments using triple-negative breast cancers show the importance of T cells in the tumor microenvironment in affecting drug predictions. In conclusion, ASGARD is a promising drug repurposing recommendation tool guided by single-cell RNA-seq for personalized medicine. ASGARD is free for educational use at https://github.com/lanagarmire/ASGARD.

q-bio.QM↗

arXiv2022

Learning with Noisy Labels over Imbalanced Subpopulations

Learning with Noisy Labels (LNL) has attracted significant attention from the research community. Many recent LNL methods rely on the assumption that clean samples tend to have "small loss". However, this assumption always fails to generalize to some real-world cases with imbalanced subpopulations, i.e., training subpopulations varying in sample size or recognition difficulty. Therefore, recent LNL methods face the risk of misclassifying those "informative" samples (e.g., hard samples or samples in the tail subpopulations) into noisy samples, leading to poor generalization performance. To address the above issue, we propose a novel LNL method to simultaneously deal with noisy labels and imbalanced subpopulations. It first leverages sample correlation to estimate samples' clean probabilities for label correction and then utilizes corrected labels for Distributionally Robust Optimization (DRO) to further improve the robustness. Specifically, in contrast to previous works using classification loss as the selection criterion, we introduce a feature-based metric that takes the sample correlation into account for estimating samples' clean probabilities. Then, we refurbish the noisy labels using the estimated clean probabilities and the pseudo-labels from the model's predictions. With refurbished labels, we use DRO to train the model to be robust to subpopulation imbalance. Extensive experiments on a wide range of benchmarks demonstrate that our technique can consistently improve current state-of-the-art robust learning paradigms against noisy labels, especially when encountering imbalanced subpopulations.

cs.LG↗