arXiv subjects

Blasco Morozzo della Rocca

Publications and source records attributed to Blasco Morozzo della Rocca.

3 recordsLinked to original sources

arXiv2026

A Proof of Concept for a Digital Twin of an Ultrasonic Fermentation System

This paper presents the design and implementation of a proof of concept digital twin for an innovative ultrasonic-enhanced beer-fermentation system, developed to enable intelligent monitoring, prediction, and actuation in yeast-growth environments. A traditional fermentation tank is equipped with a piezoelectric transducer able to irradiate the tank with ultrasonic waves, providing an external abiotic stimulus to enhance the growth of yeast and accelerate the fermentation process. At its core, the digital twin incorporates a predictive model that estimates yeast's culture density over time based on the surrounding environmental conditions. To this end, we implement, tailor and extend the model proposed in Palacios et al., allowing us to effectively handle the limited number of available training samples by using temperature, ultrasonic frequency, and duty cycle as inputs. The results obtained along with the assessment of model performance demonstrate the feasibility of the proposed approach.

cs.ET↗

arXiv2023

Hydrophobically gated memristive nanopores for neuromorphic applications

Brain-inspired computing has the potential to revolutionise the current von Neumann architecture, advancing machine learning applications. Signal transmission in the brain relies on voltage-gated ion channels, which exhibit the electrical behaviour of memristors, resistors with memory. State-of-the-art technologies currently employ semiconductor-based neuromorphic approaches, which have already demonstrated their efficacy in machine learning systems. However, these approaches still cannot match performance achieved by biological neurons in terms of energy efficiency and size. In this study, we utilise molecular dynamics simulations, continuum models, and electrophysiological experiments to propose and realise a bioinspired hydrophobically gated memristive nanopore. Our findings indicate that hydrophobic gating enables memory through an electrowetting mechanism, and we establish simple design rules accordingly. Through the engineering of a biological nanopore, we successfully replicate the characteristic hysteresis cycles of a memristor \tr{and construct a synaptic device capable of learning and forgetting}. This advancement offers a promising pathway for the realization of nanoscale, cost- and energy-effective, and adaptable bioinspired memristors.

cond-mat.mes-hall↗

arXiv2022

Geometrically Induced Selectivity and Unidirectional Electroosmosis in Uncharged Nanopores

Selectivity towards positive and negative ions in nanopores is often associated with electroosmotic flow, the control of which is pivotal in several micro-nanofluidic technologies. Selectivity is traditionally understood to be a consequence of surface charges that alter the ion distribution in the pore lumen. Here we present a purely geometrical mechanism to induce ionic selectivity and electroosmotic flow in uncharged nanopores and we tested it via molecular dynamics simulations. Our approach exploits the accumulation of charges, driven by an external electric field, in a coaxial cavity that decorates the membrane close to the pore entrance. The selectivity was shown to depend on the applied voltage and results to be completely inverted when reverting the voltage. The simultaneous inversion of ionic selectivity and electric field direction causes a unidirectional electroosmotic flow. We developed a quantitatively accurate theoretical model for designing pore geometry to achieve the desired electroosmotic velocity. Finally, we demonstrate that unidirectional electroosmosis also occurs for a biological pore whose structure presents a coaxial cavity surrounding the pore constriction. The capability to induce ion selectivity without altering the pore lumen shape or the surface charge may open the way to a more flexible design of selective membranes.

physics.flu-dyn↗