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Bo Zhang

Publications and source records attributed to Bo Zhang.

At least 145 records · Page 8Linked to original sources
arXiv2026

Efficient estimation of cumulative incidence curves via data fusion with surrogates: application to integrated analysis of vaccine trial and immunobridging data

Refined vaccine regimens containing variant-matched inserts are often authorized based on historical phase 3 efficacy trials together with immunobridging studies. Phase 3 trials are essential for establishing immune biomarkers that reliably predict disease risk or vaccine efficacy against clinical endpoints. Once such immune correlates are identified, updated vaccine regimens can be approved through immunobridging designs that compare the immunogenicity of the updated regimen to that of an already-approved vaccine. We develop methods of inference for the counterfactual cumulative incidence curve using participant-level data from both a historical vaccine efficacy trial and an immunobridging study. We further extend these methods to pathogens with multiple serotypes -- such as dengue virus and influenza -- by estimating cause-specific cumulative incidence curves. We describe the identification assumptions, propose efficient and multiply robust estimators, and assess their finite-sample performance through simulation studies. We then apply the proposed methods to (1) estimating the hypothetical cumulative incidence curve for a bivalent mRNA booster and (2) testing a key assumption of no controlled direct effects, using data from the COVID-19 Variant Immunologic Landscape (COVAIL) Trial, a multistage randomized clinical study evaluating the safety and immunogenicity of a second COVID-19 booster dose.

stat.ME↗
arXiv2026

NTIRE 2026 The 3rd Restore Any Image Model (RAIM) Challenge: AI Flash Portrait (Track 3)

In this paper, we present a comprehensive overview of the NTIRE 2026 3rd Restore Any Image Model (RAIM) challenge, with a specific focus on Track 3: AI Flash Portrait. Despite significant advancements in deep learning for image restoration, existing models still encounter substantial challenges in real-world low-light portrait scenarios. Specifically, they struggle to achieve an optimal balance among noise suppression, detail preservation, and faithful illumination and color reproduction. To bridge this gap, this challenge aims to establish a novel benchmark for real-world low-light portrait restoration. We comprehensively evaluate the proposed algorithms utilizing a hybrid evaluation system that integrates objective quantitative metrics with rigorous subjective assessment protocols. For this competition, we provide a dataset containing 800 groups of real-captured low-light portrait data. Each group consists of a 1K-resolution low-light input image, a 1K ground truth (GT), and a 1K person mask. This challenge has garnered widespread attention from both academia and industry, attracting over 100 participating teams and receiving more than 3,000 valid submissions. This report details the motivation behind the challenge, the dataset construction process, the evaluation metrics, and the various phases of the competition. The released dataset and baseline code for this track are publicly available from the same \href{https://github.com/zsn1434/AI_Flash-BaseLine/tree/main}{GitHub repository}, and the official challenge webpage is hosted on \href{https://www.codabench.org/competitions/12885/}{CodaBench}.

cs.CV↗
arXiv2026

NTIRE 2026 The 3rd Restore Any Image Model (RAIM) Challenge: Multi-Exposure Image Fusion in Dynamic Scenes (Track 2)

This paper presents NTIRE 2026, the 3rd Restore Any Image Model (RAIM) challenge on multi-exposure image fusion in dynamic scenes. We introduce a benchmark that targets a practical yet difficult HDR imaging setting, where exposure bracketing must be fused under scene motion, illumination variation, and handheld camera jitter. The challenge data contains 100 training sequences with 7 exposure levels and 100 test sequences with 5 exposure levels, reflecting real-world scenarios that frequently cause misalignment and ghosting artefacts. We evaluate submissions with a leaderboard score derived from PSNR, SSIM, and LPIPS, while also considering perceptual quality, efficiency, and reproducibility during the final review. This track attracted 114 participating teams and received 987 submissions. The winning methods significantly improved the ability to remove artifacts from multi-exposure fusion and recover fine details. The dataset and the code of each team can be found at the repository: https://github.com/qulishen/RAIM-HDR.

cs.CV↗
arXiv2026

Scheduling Cause-Effect Chains without Timing Anomalies in End-to-End Latency

In real-time systems, both individual task execution and data propagation must meet strict timing constraints. Cause-effect (CE) chains are widely used to analyze such behaviors by end-to-end latency. However, timing anomalies (TAs) can distort it, where a local reduction in execution times leads to an increase in the overall end-to-end latency. As a result, precisely analyzing the upper bounds of the latency becomes challenging, and such systems typically exhibit larger upper bounds than TA-eliminated systems. Existing studies either eliminate TAs by completely sacrificing average latency to simplify analysis or, despite adopting complex safe analysis methods, do not eliminate TAs effectively, still having high latencies. To address this issue, we identify two basic causes of TAs in end-to-end latency. Based on these causes, we propose the first treatment that eliminates TAs in the latency with negligible average latency loss using Deterministic Data Flow (DDF). We further formally prove its TA-free property. Therefore, we can get a precise upper bound for latency when all jobs execute with their worst-case execution times. Experimental results show that it effectively reduces the maximum end-to-end latency, the average latency, and latency jitter compared with the state-of-the-art (SOTA) method.

eess.SY↗
arXiv2026

JoyAI-LLM Flash: Advancing Mid-Scale LLMs with Token Efficiency

We introduce JoyAI-LLM Flash, an efficient Mixture-of-Experts (MoE) language model designed to redefine the trade-off between strong performance and token efficiency in the sub-50B parameter regime. JoyAI-LLM Flash is pretrained on a massive corpus of 20 trillion tokens and further optimized through a rigorous post-training pipeline, including supervised fine-tuning (SFT), Direct Preference Optimization (DPO), and large-scale reinforcement learning (RL) across diverse environments. To improve token efficiency, JoyAI-LLM Flash strategically balances \emph{thinking} and \emph{non-thinking} cognitive modes and introduces FiberPO, a novel RL algorithm inspired by fibration theory that decomposes trust-region maintenance into global and local components, providing unified multi-scale stability control for LLM policy optimization. To enhance architectural sparsity, the model comprises 48B total parameters while activating only 2.7B parameters per forward pass, achieving a substantially higher sparsity ratio than contemporary industry leading models of comparable scale. To further improve inference throughput, we adopt a joint training-inference co-design that incorporates dense Multi-Token Prediction (MTP) and Quantization-Aware Training (QAT). We release the checkpoints for both JoyAI-LLM-48B-A3B Base and its post-trained variants on Hugging Face to support the open-source community.

cs.CL↗
arXiv2026

Dealing with positivity violations in mediation analysis via weighted controlled effects, with application to assessing immune correlates of protection in antigen-experienced participants

Causal mediation analysis has become an important and increasingly used framework for evaluating candidate immune response biomarkers in vaccine research. A controlled effects approach has been proposed to estimate controlled risk curves under a counterfactual scenario in which the entire study population is vaccinated and their post-vaccination immune responses are set to a range of fixed levels. This framework performs well when the study population is antigenically naïve, that is, individuals have not been previously exposed to the antigen, as is common in HIV-1 vaccine research and during the early phases of the COVID-19 pandemic. However, the controlled effects framework becomes more challenging to apply in antigen-experienced populations, where prior vaccination or infection has occurred, as in the case of influenza, dengue, and more recent phases of the COVID-19 pandemic. In such settings, a key identification assumption for valid causal mediation analysis, the positivity assumption, is violated: it is no longer plausible to conceive of a hypothetical intervention that sets a post-vaccination immune marker to a fixed level below an individual's baseline immune level. In this article, we introduce a weighted controlled risk approach that targets a subpopulation for whom there is a prespecified probability of attaining a post-vaccination immune marker level. We further generalize this framework to study contrasts of controlled risks for relevant subpopulations. We demonstrate the validity of the proposed estimators through simulation studies and apply the method to reanalyze post-vaccination neutralizing antibody titers against Omicron BA.4/BA.5 as an immune correlate of COVID-19 in the Coronavirus Variant Immunologic Landscape (COVAIL) trial. R code to implement the proposed method can be found on Github: https://github.com/Qijia-He/weighted_CVE.

stat.ME↗
arXiv2026

R2-Write: Reflection and Revision for Open-Ended Writing with Deep Reasoning

While deep reasoning with long chain-of-thought has dramatically improved large language models in verifiable domains like mathematics, its effectiveness for open-ended tasks such as writing remains unexplored. In this paper, we conduct a systematic investigation revealing that existing mainstream reasoning models achieve limited gains on open-ended writing tasks. Our further analysis shows that these models lack deep reflection and revision patterns in open-ended writing, resulting in substantially smaller improvements compared to mathematical reasoning tasks. To address this limitation, we introduce R2-Write: an automated framework that synthesizes high-quality thinking trajectories enriched with explicit reflection and revision patterns through iterative writer-judge interaction. To prevent redundant reflections, we design a process reward mechanism that supervises reflection quality during reinforcement learning, improving both performance and token efficiency. Extensive experiments across multiple creative writing and deep-research benchmarks demonstrate significant improvements, validating that explicitly incorporating reflection and revision patterns unlocks deep reasoning capabilities for open-ended writing tasks.

cs.CL↗
arXiv2026

OSGym: Scalable OS Infra for Computer Use Agents

Training computer use agents requires full-featured OS sandboxes with GUI environments, which consume substantial hardware resources as the number of sandboxes scales. Stochastic errors arising from diverse software execution within these sandboxes further demand robust infrastructure design and reliable error recovery. We present OSGym, a scalable OS environment infrastructure for computer use agents, built around these key optimization strategies: (1) Decentralized OS state management, which isolates failures to individual replicas and significantly enhances overall system reliability; (2) Hardware-aware OS replica orchestration, which addresses CPU-bounded scaling bottlenecks and substantially reduces compute overhead; (3) KVM virtualization with copy-on-write disk management, which shares a common bootable disk across VM instances and provisions only instance-specific modifications, reducing physical disk consumption by 88% and increasing disk provisioning speed by 37 times; and (4) Robust container pool with multi-layer fault recovery. Together, these optimizations yield strong scalability and resource efficiency: OSGym manages over a thousand OS replicas under constrained resources, supports parallel trajectory generation at 1420 multi-turn trajectories per minute, and reduces per-replica cost to 0.2-0.3 USD per day, a 90% reduction over standard deployment. Our experiments validate OSGym across end-to-end pipelines for data collection and training for computer use agents. We believe OSGym establishes a new foundation for scalable, general-purpose computer use agent research.

cs.DC↗
arXiv2026

Intern-S1-Pro: Scientific Multimodal Foundation Model at Trillion Scale

We introduce Intern-S1-Pro, the first one-trillion-parameter scientific multimodal foundation model. Scaling to this unprecedented size, the model delivers a comprehensive enhancement across both general and scientific domains. Beyond stronger reasoning and image-text understanding capabilities, its intelligence is augmented with advanced agent capabilities. Simultaneously, its scientific expertise has been vastly expanded to master over 100 specialized tasks across critical science fields, including chemistry, materials, life sciences, and earth sciences. Achieving this massive scale is made possible by the robust infrastructure support of XTuner and LMDeploy, which facilitates highly efficient Reinforcement Learning (RL) training at the 1-trillion parameter level while ensuring strict precision consistency between training and inference. By seamlessly integrating these advancements, Intern-S1-Pro further fortifies the fusion of general and specialized intelligence, working as a Specializable Generalist, demonstrating its position in the top tier of open-source models for general capabilities, while outperforming proprietary models in the depth of specialized scientific tasks.

cs.LG↗
arXiv2026

Project Imaging-X: A Survey of 1000+ Open-Access Medical Imaging Datasets for Foundation Model Development

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.

cs.CV↗
arXiv2026

TrustGeoGen: Formal-Verified Data Engine for Trustworthy Multi-modal Geometric Problem Solving

Geometric problem solving (GPS) requires precise multimodal understanding and rigorous, step-by-step logical reasoning. However, developing capable Multimodal Large Language Models (MLLMs) for GPS is heavily bottlenecked by the scarcity of high-quality, verifiable data. Existing data acquisition paradigms either suffer from modality incompleteness and unverified logical gaps ("leaps-of-faith"), or rely on formal engines that generate rigid, structurally homogeneous data, failing to produce high-difficulty problems or foster genuine natural-language reasoning. To overcome these limitations, we introduce TrustGeoGen, an autonomous and formalized geometric data generation engine. TrustGeoGen strictly guarantees reasoning trustworthiness through formal verification while generating multimodally integrated data, including premises, visual diagrams, and solutions. To systematically scale problem difficulty, we incorporates difficulty-aware filtering and iterative bootstrapping mechanism. Furthermore, we propose "connection thinking" to bridge the semantic gap between rigid formal logic and fluent human-like reasoning, ensuring coherent logical transitions. We also introduce the GeoExplore family of sampling algorithms to extract diverse problem-solving trajectories based on various thinking templates. Extensive experiments demonstrate that training models on our synthesized dataset, GeoTrust, substantially enhances deep geometric reasoning capabilities and yields significant performance gains across out-of-distribution (OOD) benchmarks, including GeoQA, Geometry3K, and OlympiadBench.Our code and data can be found at https://github.com/InternScience/TrustGeoGen

cs.AI↗
arXiv2026

THEMIS: Towards Holistic Evaluation of MLLMs for Scientific Paper Fraud Forensics

We present THEMIS, a novel multi-task benchmark designed to comprehensively evaluate multimodal large language models (MLLMs) on visual fraud reasoning within real-world academic scenarios. Compared to existing benchmarks, THEMIS introduces three major advances. (1) Real-World Scenarios and Complexity: Our benchmark comprises over 4,000 questions spanning seven scenarios, derived from authentic retracted-paper cases and carefully curated multimodal synthetic data. With 60.47% complex-texture images, THEMIS bridges the critical gap between existing benchmarks and the complexity of real-world academic fraud. (2) Fraud-Type Diversity and Granularity: THEMIS systematically covers five challenging fraud types and introduces 16 fine-grained manipulation operations. On average, each sample undergoes multiple stacked manipulation operations, with the diversity and difficulty of these manipulations demanding a high level of visual fraud reasoning from the models. (3) Multi-Dimensional Capability Evaluation: We establish a mapping from fraud types to five core visual fraud reasoning capabilities, thereby enabling an evaluation that reveals the distinct strengths and specific weaknesses of different models across these core capabilities. Experiments on 16 leading MLLMs show that even the best-performing model, GPT-5, achieves an overall performance of only 56.15%, demonstrating that our benchmark presents a stringent test. We expect THEMIS to advance the development of MLLMs for complex, real-world fraud reasoning tasks.

cs.CV↗
arXiv2026

Evidence of Long-Lived Powerful Gyrosynchrotron Radio Emission in the Close Binary FF UMa

RS Canum Venaticorum (RS CVn) close binaries, characterized by tidal locking, rapid rotations, and strong magnetic fields, are ideal laboratories for high-resolution radio observations to probe emission processes, magnetic field configurations, and interaction activity. Despite their importance, only a few RS CVn sources have been explored by polarimetric observations of very long baseline interferometry (VLBI). To expand the effort, we have analyzed the existing Very Long Baseline Array (VLBA) astrometric data for the RS CVn binary FF Ursae Majoris (FF UMa). In the 5GHz VLBA experiments conducted between 2021 and 2024, both total intensity and circularly polarized emission were clearly detected at six of seven epochs. The consistently high brightness temperatures (10^7 K) and the moderate fractional circular polarization (10%-30%) over about three years indicate that the radio emission is mainly produced by gyrosynchrotron radiation from mildly relativistic electrons in the highly-ordered magnetic field. The radio luminosities are also comparable to those of previously studied powerful RS CVn binaries and show a significant anti-correlation with fractional circular polarization. A mean centroid offset of 13.4 +/- 3.1 solar radii between the Stokes I and V emission was found across multiple epochs, indicating a possible additional contribution from the secondary star via a magnetically active corona, a giant magnetic loop, or significant interaction activity with the primary star in the quiescent state.

astro-ph.SR↗
arXiv2026

VisBrowse-Bench: Benchmarking Visual-Native Search for Multimodal Browsing Agents

The rapid advancement of Multimodal Large Language Models (MLLMs) has enabled browsing agents to acquire and reason over multimodal information in the real world. But existing benchmarks suffer from two limitations: insufficient evaluation of visual reasoning ability and the neglect of native visual information of web pages in the reasoning chains. To address these challenges, we introduce a new benchmark for visual-native search, VisBrowse-Bench. It contains 169 VQA instances covering multiple domains and evaluates the models' visual reasoning capabilities during the search process through multimodal evidence cross-validation via text-image retrieval and joint reasoning. These data were constructed by human experts using a multi-stage pipeline and underwent rigorous manual verification. We additionally propose an agent workflow that can effectively drive the browsing agent to actively collect and reason over visual information during the search process. We comprehensively evaluated both open-source and closed-source models in this workflow. Experimental results show that even the best-performing model, Claude-4.6-Opus only achieves an accuracy of 47.6%, while the proprietary Deep Research model, o3-deep-research only achieves an accuracy of 41.1%. The code and data can be accessed at: https://github.com/ZhengboZhang/VisBrowse-Bench

cs.CV↗
arXiv2026

AdaZoom-GUI: Adaptive Zoom-based GUI Grounding with Instruction Refinement

GUI grounding is a critical capability for vision-language models (VLMs) that enables automated interaction with graphical user interfaces by locating target elements from natural language instructions. However, grounding on GUI screenshots remains challenging due to high-resolution images, small UI elements, and ambiguous user instructions. In this work, we propose AdaZoom-GUI, an adaptive zoom-based GUI grounding framework that improves both localization accuracy and instruction understanding. Our approach introduces an instruction refinement module that rewrites natural language commands into explicit and detailed descriptions, allowing the grounding model to focus on precise element localization. In addition, we design a conditional zoom-in strategy that selectively performs a second-stage inference on predicted small elements, improving localization accuracy while avoiding unnecessary computation and context loss on simpler cases. To support this framework, we construct a high-quality GUI grounding dataset and train the grounding model using Group Relative Policy Optimization (GRPO), enabling the model to predict both click coordinates and element bounding boxes. Experiments on public benchmarks demonstrate that our method achieves state-of-the-art performance among models with comparable or even larger parameter sizes, highlighting its effectiveness for high-resolution GUI understanding and practical GUI agent deployment.

cs.CV↗
arXiv2026

ViRC: Enhancing Visual Interleaved Mathematical CoT with Reason Chunking

CoT has significantly enhanced the reasoning ability of LLMs while it faces challenges when extended to multimodal domains, particularly in mathematical tasks. Existing MLLMs typically perform textual reasoning solely from a single static mathematical image, overlooking dynamic visual acquisition during reasoning. In contrast, humans repeatedly examine visual image and employ step-by-step reasoning to prove intermediate propositions. This strategy of decomposing the problem-solving process into key logical nodes adheres to Miller's Law in cognitive science. Inspired by this insight, we propose a ViRC framework for multimodal mathematical tasks, introducing a Reason Chunking mechanism that structures multimodal mathematical CoT into consecutive Critical Reasoning Units (CRUs) to simulate human expert problem-solving patterns. CRUs ensure intra-unit textual coherence for intermediate proposition verification while integrating visual information across units to generate subsequent propositions and support structured reasoning. To this end, we present CRUX dataset by using three visual tools and four reasoning patterns to provide explicitly annotated CRUs across multiple reasoning paths for each mathematical problem. Leveraging the CRUX dataset, we propose a progressive training strategy inspired by human cognitive learning, which includes Instructional SFT, Practice SFT, and Strategic RL, aimed at further strengthening the Reason Chunking ability of the model. The resulting ViRC-7B model achieves a 18.8% average improvement over baselines across multiple mathematical benchmarks. Code is available at https://github.com/Leon-LihongWang/ViRC.

cs.CV↗
arXiv2026

AutoSkill: Experience-Driven Lifelong Learning via Skill Self-Evolution

In practical LLM applications, users repeatedly express stable preferences and requirements, such as reducing hallucinations, following institutional writing conventions, or avoiding overly technical wording, yet such interaction experience is seldom consolidated into reusable knowledge. Consequently, LLM agents often fail to accumulate personalized capabilities across sessions. We present AutoSkill, an experience-driven lifelong learning framework that enables LLM agents to automatically derive, maintain, and reuse skills from dialogue and interaction traces. AutoSkill abstracts skills from user experience, supports their continual self-evolution, and dynamically injects relevant skills into future requests without retraining the underlying model. Designed as a model-agnostic plugin layer, it is compatible with existing LLMs and introduces a standardized skill representation for sharing and transfer across agents, users, and tasks. In this way, AutoSkill turns ephemeral interaction experience into explicit, reusable, and composable capabilities. This paper describes the motivation, architecture, skill lifecycle, and implementation of AutoSkill, and positions it with respect to prior work on memory, retrieval, personalization, and agentic systems. AutoSkill highlights a practical and scalable path toward lifelong personalized agents and personal digital surrogates.

cs.AI↗
arXiv2026

BACE-RUL: A Bi-directional Adversarial Network with Covariate Encoding for Machine Remaining Useful Life Prediction

Prognostic and Health Management (PHM) are crucial ways to avoid unnecessary maintenance for Cyber-Physical Systems (CPS) and improve system reliability. Predicting the Remaining Useful Life (RUL) is one of the most challenging tasks for PHM. Existing methods require prior knowledge about the system, contrived assumptions, or temporal mining to model the life cycles of machine equipment/devices, resulting in diminished accuracy and limited applicability in real-world scenarios. This paper proposes a Bi-directional Adversarial network with Covariate Encoding for machine Remaining Useful Life (BACE-RUL) prediction, which only adopts sensor measurements from the current life cycle to predict RUL rather than relying on previous consecutive cycle recordings. The current sensor measurements of mechanical devices are encoded to a conditional space to better understand the implicit inner mechanical status. The predictor is trained as a conditional generative network with the encoded sensor measurements as its conditions. Various experiments on several real-world datasets, including the turbofan aircraft engine dataset and the dataset collected from degradation experiments of Li-Ion battery cells, show that the proposed model is a general framework and outperforms state-of-the-art methods.

cs.LG↗