arXiv subjects

Bo-Rong Lin

Publications and source records attributed to Bo-Rong Lin.

5 recordsLinked to original sources

arXiv2026

Impact of Nonlinear Absorption on Energy Distribution During FLASH-Like Deposition

FLASH radiotherapy for tumors has proven highly effective in preserving normal tissue; however, the physical origin of its biological selectivity has yet to be elucidated. This study developed a minimal diffusion-absorption model to examine the effects of nonlinear energy absorption on the spatial distribution of energy during FLASH-like deposition. Simulations revealed that nonlinear absorption alters the transfer of energy through the system while reducing the amount of energy absorbed in surrounding, unexposed regions. This behavior qualitatively resembles the tissue-sparing effect observed in FLASH radiotherapy. Parameter-space analysis revealed that the effect of incident pulse intensity depends on the absorption properties of the material, including its saturation behavior and energy threshold. These results suggest that energy-deposition conditions should be matched to the absorption characteristics of the target material.

physics.app-ph↗

arXiv2019

Process Verification of Magnetic Ion Embedded Nanodiamonds Using Secondary Ion Mass Spectroscopy

Ion implantation is used to create magnetic ion embedded nanodiamonds for use in a wide range of biological and medical applications; however, the effectiveness of this process depends heavily on separating magnetic nanodiamonds from non-magnetic ones. In this study, we use secondary ion mass spectrometry to assess the distribution of magnetic ions and verify the success of separation. When applied to a series of iron/manganese embedded nanodiamonds, the sorting tool used in this study proved highly effective in selecting magnetic nanodiamonds. This paper also discusses the major challenges involved in the further development of this technology.

physics.app-ph↗

arXiv2019

Iron Embedded Magnetic Nanodiamonds for in vivo MRI Contrast Enhancement

Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of NDs and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging.

physics.med-ph↗

arXiv2018

A New Boron-10 Delivery Agent for Boron Neutron Capture Therapy: Fluorescent Boron-10 Embedded Nanodiamonds

Boron neutron capture therapy is a powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron therapy. In this study, we fabricate highly bio-compatible boron-10 embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. The red fluorescence of the nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent boron-10 embedded nanodiamonds, combining optical visibility and boron-10 transport capability, are a promising boron delivery agent suitable for a wide range of biomedical applications.

physics.bio-ph↗

arXiv2017

Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI

We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The image enhancement was shown clearly through T2 weighted images. The concentration dependence of the T2 relaxation time gives a relaxivity value that is about seven times that of the regular non-magnetic nanodiamonds. Cell viability study has also been performed. It was shown that they were nearly free from cytotoxicity independent of the particle concentration used. The imaging capability demonstrated here adds a new dimension to the medical application of nanodiamonds. In the future one will be able to combine this capability of magnetic nanodiamonds with other functions through surface modifications to perform drug delivery, targeted therapy, localized thermal treatment and diagnostic imaging at the same time.

physics.bio-ph↗