arXiv subjects

Boris Baeumer

Publications and source records attributed to Boris Baeumer.

20 records · Page 2Linked to original sources

arXiv2009

Predicting the Drug Release Kinetics of Matrix Tablets

In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.

physics.med-ph↗

arXiv2007

Brownian subordinators and fractional Cauchy problems

A Brownian time process is a Markov process subordinated to the absolute value of an independent one-dimensional Brownian motion. Its transition densities solve an initial value problem involving the square of the generator of the original Markov process. An apparently unrelated class of processes, emerging as the scaling limits of continuous time random walks, involve subordination to the inverse or hitting time process of a classical stable subordinator. The resulting densities solve fractional Cauchy problems, an extension that involves fractional derivatives in time. In this paper, we will show a close and unexpected connection between these two classes of processes, and consequently, an equivalence between these two families of partial differential equations.

math.PR↗