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Bouchra Nasri

Publications and source records attributed to Bouchra Nasri.

3 recordsLinked to original sources

Fluctuations and Long-Time Stability of Multivariate Ensemble Kalman Filters

We develop a self contained stochastic perturbation theory for discrete generation and multivariate Ensemble Kalman filters. Unlike their continuous-time counterparts, discrete EnKF algorithms are defined through a two steps prediction update mechanism and exhibit non Gaussian fluctuations, even in linear settings. In the multivariate case, these fluctuations take the form of non central Wishart type perturbations, which significantly complicate the mathematical analysis. We establish non asymptotic, time-uniform stability and error estimates for the ensemble covariance matrix processes under minimal structural assumptions on the signal observation model, allowing for possibly unstable dynamics. Our results quantify the impact of ensemble size, dimension, and observation noise, and provide explicit bounds on the propagation of stochastic errors over long time horizons. The analysis relies on a detailed study of stochastic Riccati difference equations driven by matrix-valued noncentral Wishart fluctuations. Beyond their relevance to data assimilation, these results contribute to the probabilistic understanding of ensemble-based filtering methods in high dimension and offer new tools for the analysis of interacting particle systems with matrix-valued dynamics.

math.PR

Mathematical modelling of the first HIV/ZIKV co-infection cases in Colombia and Brazil

This paper presents a mathematical model to investigate co-infection with HIV/AIDS and zika virus (ZIKV) in Colombia and Brazil, where the first cases were reported in 2015-2016. The model considers the sexual transmission dynamics of both viruses and vector-host interactions. We begin by exploring the qualitative behaviour of each model separately. Then, we analyze the dynamics of the co-infection model using the thresholds and results defined separately for each model. The model also considers the impact of intervention strategies, such as, personal protection, antiretroviral therapy (ART), and sexual protection (condoms use). Using available parameter values for Colombia and Brazil, the model is calibrated to predict the potential effect of implementing combinations of those intervention strategies on the co-infection spread. According to these findings, transmission through sexual contact is a determining factor in the long-term behaviour of these two diseases. Furthermore, it is important to note that co-infection with HIV and ZIKV may result in higher rates of HIV transmission and an increased risk of severe congenital disabilities linked to ZIKV infection. As a result, control measures have been implemented to limit the number of infected individuals and mosquitoes, with the aim of halting disease transmission. This study provides novel insights into the dynamics of HIV/ZIKV co-infection and highlights the importance of integrated intervention strategies in controlling the spread of these viruses, which may impact public health

q-bio.PE

Assessing the Impact of Mutations and Horizontal Gene Transfer on the AMR Control: A Mathematical Model

Antimicrobial resistance (AMR) poses a significant threat to public health by increasing mortality, extending hospital stays, and increasing healthcare costs. It affects people of all ages and affects health services, veterinary medicine, and agriculture, making it a pressing global issue. Mathematical models are required to predict the behaviour of AMR and to develop control measures to eliminate resistant bacteria or reduce their prevalence. This study presents a simple deterministic mathematical model in which sensitive and resistant bacteria interact in the environment, and mobile genetic elements (MGEs) are functions that depend on resistant bacteria. We analyze the qualitative properties of the model and propose an optimal control problem in which avoiding mutations and horizontal gene transfer (HGT) are the primary control strategies. We also provide a case study of the resistance and multidrug resistance (MDR) percentages of Escherichia coli to gentamicin and amoxicillin in some European countries using data from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Our theoretical results and numerical experiments indicate that controlling the spread of resistance in southern European regions through the supply of amoxicillin is challenging. However, the host immune system is also critical for controlling AMR.

math.DS