arXiv subjects

Boya Wang

Publications and source records attributed to Boya Wang.

11 recordsLinked to original sources

arXiv2026

DINO-Med: A Unified Patch-Based Adaptation Framework for Multi-Modal Medical Image Analysis Applied to Liver Fibrosis Staging

Adapting natural-image foundation models like DINOv3 to multi-modal medical imaging is challenging due to the significant domain gap between natural color images and multi-channel medical scans. We present a unified, patch-based framework that processes raw multimodal imaging through training-free registration, automated localization, and mask-filtered patch extraction. This architecture culminates in a hierarchical strategy that aggregates patch-level insights into subject-level diagnostics. Using liver fibrosis staging as a case study, we evaluate four patch-level feature representations: handcrafted Radiomics features, learned ResNet features, pre-trained foundation model SAM-Med2D features, and frozen DINOv3 features. To ensure a controlled comparison, all models utilize the same lightweight MLP head and are evaluated across both rigid and deformable registration settings. Our training protocol focuses on mild fibrosis (S1) and cirrhosis (S4) classes only, enabling a single classifier to address both substantial fibrosis detection and cirrhosis staging. Evaluated via 10 random train (90%)/ test (10%) splits on 360 subjects from the CARE 2025 Liver Track 4 cohort, our DINOv3-based framework significantly outperforms all baselines, achieving the best classification accuracy of 78.4% for S1 and 75.8% for S4.

cs.CV↗

arXiv2026

Embedded Blockchain Infrastructure Management (eBIM): A RISC-V-Empowered Hardware--Software Co-Design Framework Towards Trustworthy Blockchain

Blockchain systems are undergoing a fundamental transition from decentralized ledgers for digital assets to general-purpose trust infrastructures for verifiable computation, decentralized physical resources, and automated infrastructure management. Meanwhile, the limitations of the Blockchain as a Service (BaaS) model stem from a common structural problem: outsourcing control of infrastructure to third-party service providers inevitably involves a systemic surrender of trust, flexibility, and data sovereignty. RISC-V, with its open, modular, and extensible design, provides a general-purpose computing foundation for public blockchains that is open, low-level, compileable, verifiable, and scalable. Inspired by the development and characteristics of eSIM, the embedded Blockchain infrastructure management (eBIM) is defined as a software-hardware collaborative paradigm for blockchain infrastructure management with RISC-V. This study aims to provide a comprehensive survey on eBIM supporting research and technologies, to answer the following research questions (RQs): RQ1 What is eBIM? RQ2 How does eBIM work? RQ3 What can eBIM do? By introducing the concept of eBIM, this paper establishes a foundational reference for researchers, hardware architects, and protocol designers in this rapidly evolving landscape, including cryptographic acceleration, trusted execution environments, zero-knowledge virtual machines, and smart contract execution engines. The prospects of the proposed e-BIM and its future research directions are indicated in this paper.

cs.CR↗

arXiv2026

How Far Has AI Come in Liver Fibrosis Staging? A Large-Scale Real-World Dataset and Benchmark

Despite years of methodological progress, how far AI has come in liver fibrosis staging has never been systematically evaluated under the heterogeneous, multi-center conditions that define clinical practice. To address this gap, we introduce LiFS, a large-scale dataset and benchmark derived from the MICCAI 2025 CARE-Liver challenge, comprising 610 patients across multiple centers and scanners with multi-sequence MRI. To the best of our knowledge, LiFS is the first benchmark providing complete gadoxetic acid-enhanced sequences with histopathology-confirmed annotations from diverse real-world scanners. Through systematic evaluation of 9 independently developed methods selected from 96 registered teams against in-cohort radiologist reference results, our findings address how far current AI has progressed toward clinical-level liver fibrosis staging from three complementary perspectives. First, against radiologists, the best AI methods were broadly comparable to the senior radiologist and significantly exceeded the junior radiologist in selected settings, while median AI performance generally approached junior-radiologist levels. Second, from a data perspective, cross-center heterogeneity, label imbalance, and contrast-enhanced sequence variability emerge as the dominant challenges for AI methods. Third, from a technical perspective, methodological design choices, including spatial registration, input dimensionality, multi-modal fusion strategy, and backbone architecture, appear to modulate cross-center robustness, although no single choice alone closes the gap. Overall, LiFS provides a rigorous real-world benchmark for positioning the current state of AI in liver fibrosis staging and for enabling future research on the key challenges that limit clinically reliable deployment.

cs.CV↗

arXiv2026

Search-MIND: Training-Free Multi-Modal Medical Image Registration

Multi-modal image registration plays a critical role in precision medicine but faces challenges from non-linear intensity relationships and local optima. While deep learning models enable rapid inference, they often suffer from generalization collapse on unseen modalities. To address this, we propose Search-MIND, a training-free, iterative optimization framework for instance-specific registration. Our pipeline utilizes a coarse-to-fine strategy: a hierarchical coarse alignment stage followed by deformable refinement. We introduce two novel loss functions: Variance-Weighted Mutual Information (VWMI), which prioritizes informative tissue regions to shield global alignment from background noise and uniform regions, and Search-MIND (S-MIND), which broadens the convergence basin of structural descriptors by considering larger local search range. Evaluations on CARE Liver 2025 and CHAOS Challenge datasets show that Search-MIND consistently outperforms classical baselines like ANTs and foundation model-based approaches like DINO-reg, offering superior stability across diverse modalities.

eess.IV↗

arXiv2026

Semi-supervised Liver Segmentation and Patch-based Fibrosis Staging with Registration-aided Multi-parametric MRI

Liver fibrosis poses a substantial challenge in clinical practice, emphasizing the necessity for precise liver segmentation and accurate disease staging. Based on the CARE Liver 2025 Track 4 Challenge, this study introduces a multi-task deep learning framework developed for liver segmentation (LiSeg) and liver fibrosis staging (LiFS) using multiparametric MRI. The LiSeg phase addresses the challenge of limited annotated images and the complexities of multi-parametric MRI data by employing a semi-supervised learning model that integrates image segmentation and registration. By leveraging both labeled and unlabeled data, the model overcomes the difficulties introduced by domain shifts and variations across modalities. In the LiFS phase, we employed a patchbased method which allows the visualization of liver fibrosis stages based on the classification outputs. Our approach effectively handles multimodality imaging data, limited labels, and domain shifts. The proposed method has been tested by the challenge organizer on an independent test set that includes in-distribution (ID) and out-of-distribution (OOD) cases using three-channel MRIs (T1, T2, DWI) and seven-channel MRIs (T1, T2, DWI, GED1-GED4). The code is freely available. Github link: https://github.com/mileywang3061/Care-Liver

cs.CV↗

arXiv2025

SKYLENAGE Technical Report: Mathematical Reasoning and Contest-Innovation Benchmarks for Multi-Level Math Evaluation

Large language models (LLMs) now perform strongly on many public math suites, yet frontier separation within mathematics increasingly suffers from ceiling effects. We present two complementary benchmarks: SKYLENAGE-ReasoningMATH, a 100-item, structure-aware diagnostic set with per-item metadata on length, numeric density, and symbolic complexity; and SKYLENAGE-MATH, a 150-item contest-style suite spanning four stages from high school to doctoral under a seven-subject taxonomy. We evaluate fifteen contemporary LLM variants under a single setup and analyze subject x model and grade x model performance. On the contest suite, the strongest model reaches 44% while the runner-up reaches 37%; accuracy declines from high school to doctoral, and top systems exhibit a doctoral-to-high-school retention near 79%. On the reasoning set, the best model attains 81% overall, and hardest-slice results reveal clear robustness gaps between leaders and the mid-tier. In summary, we release SKYLENAGE-ReasoningMATH and report aggregate results for SKYLENAGE-MATH; together, SKYLENAGE provides a hard, reasoning-centered and broadly covering math benchmark with calibrated difficulty and rich metadata, serving as a reference benchmark for future evaluations of mathematical reasoning.

cs.CL↗

arXiv2025

A stochastic agent-based model for simulating tumor-immune dynamics and evaluating therapeutic strategies

Tumor-immune interactions are central to cancer progression and treatment outcomes. In this study, we present a stochastic agent-based model that integrates cellular heterogeneity, spatial cell-cell interactions, and drug resistance evolution to simulate tumor growth and immune response in a two-dimensional microenvironment. The model captures dynamic behaviors of four major cell types--tumor cells, cytotoxic T lymphocytes, helper T cells, and regulatory T cells--and incorporates key biological processes such as proliferation, apoptosis, migration, and immune regulation. Using this framework, we simulate tumor progression under different therapeutic interventions, including radiotherapy, targeted therapy, and immune checkpoint blockade. Our simulations reproduce emergent phenomena such as immune privilege and spatial immune exclusion. Quantitative analyses show that all therapies suppress tumor growth to varying degrees and reshape the tumor microenvironment. Notably, combination therapies--especially targeted therapy with immunotherapy--achieve the most effective tumor control and delay the emergence of resistance. Additionally, sensitivity analyses reveal a nonlinear relationship between treatment intensity and therapeutic efficacy, highlighting the existence of optimal dosing thresholds. This work demonstrates the utility of agent-based modeling in capturing complex tumor-immune dynamics and provides a computational platform for optimizing cancer treatment strategies. The model is extensible, biologically interpretable, and well-suited for future integration with experimental or clinical data.

q-bio.TO↗

arXiv2023

Not Yet Another Digital ID: Privacy-preserving Humanitarian Aid Distribution

Humanitarian aid-distribution programs help bring physical goods to people in need. Traditional paper-based solutions to support aid distribution do not scale to large populations and are hard to secure. Existing digital solutions solve these issues, at the cost of collecting large amount of personal information. This lack of privacy can endanger recipients' safety and harm their dignity. In collaboration with the International Committee of the Red Cross, we build a safe digital aid-distribution system. We first systematize the requirements such a system should satisfy. We then propose a decentralized solution based on the use of tokens that fulfills the needs of humanitarian organizations. It provides scalability and strong accountability, and, by design, guarantees the recipients' privacy. We provide two instantiations of our design, on a smart card and on a smartphone. We formally prove the security and privacy properties of these solutions, and empirically show that they can operate at scale.

cs.CR↗

arXiv2021

LCCNet: LiDAR and Camera Self-Calibration using Cost Volume Network

In this paper, we propose a novel online self-calibration approach for Light Detection and Ranging (LiDAR) and camera sensors. Compared to the previous CNN-based methods that concatenate the feature maps of the RGB image and decalibrated depth image, we exploit the cost volume inspired by the PWC-Net for feature matching. Besides the smooth L1-Loss of the predicted extrinsic calibration parameters, an additional point cloud loss is applied. Instead of regress the extrinsic parameters between LiDAR and camera directly, we predict the decalibrated deviation from initial calibration to the ground truth. During inference, the calibration error decreases further with the usage of iterative refinement and the temporal filtering approach. The evaluation results on the KITTI dataset illustrate that our approach outperforms CNN-based state-of-the-art methods in terms of a mean absolute calibration error of 0.297cm in translation and 0.017° in rotation with miscalibration magnitudes of up to 1.5m and 20°.

cs.CV↗

arXiv2021

CFNet: LiDAR-Camera Registration Using Calibration Flow Network

As an essential procedure of data fusion, LiDAR-camera calibration is critical for autonomous vehicles and robot navigation. Most calibration methods rely on hand-crafted features and require significant amounts of extracted features or specific calibration targets. With the development of deep learning (DL) techniques, some attempts take advantage of convolutional neural networks (CNNs) to regress the 6 degrees of freedom (DOF) extrinsic parameters. Nevertheless, the performance of these DL-based methods is reported to be worse than the non-DL methods. This paper proposed an online LiDAR-camera extrinsic calibration algorithm that combines the DL and the geometry methods. We define a two-channel image named calibration flow to illustrate the deviation from the initial projection to the ground truth. EPnP algorithm within the RANdom SAmple Consensus (RANSAC) scheme is applied to estimate the extrinsic parameters with 2D-3D correspondences constructed by the calibration flow. Experiments on KITTI datasets demonstrate that our proposed method is superior to the state-of-the-art methods. Furthermore, we propose a semantic initialization algorithm with the introduction of instance centroids (ICs). The code will be publicly available at https://github.com/LvXudong-HIT/CFNet.

cs.RO↗

arXiv2020

Semantic Flow-guided Motion Removal Method for Robust Mapping

Moving objects in scenes are still a severe challenge for the SLAM system. Many efforts have tried to remove the motion regions in the images by detecting moving objects. In this way, the keypoints belonging to motion regions will be ignored in the later calculations. In this paper, we proposed a novel motion removal method, leveraging semantic information and optical flow to extract motion regions. Different from previous works, we don't predict moving objects or motion regions directly from image sequences. We computed rigid optical flow, synthesized by the depth and pose, and compared it against the estimated optical flow to obtain initial motion regions. Then, we utilized K-means to finetune the motion region masks with instance segmentation masks. The ORB-SLAM2 integrated with the proposed motion removal method achieved the best performance in both indoor and outdoor dynamic environments.

cs.CV↗