arXiv subjects

Brian J. Reich

Publications and source records attributed to Brian J. Reich.

At least 19 recordsLinked to original sources

arXiv2026

Spatial causal inference in the presence of preferential sampling to study the impacts of marine protected areas

Marine Protected Areas (MPAs) have been established globally to conserve marine resources. Given their maintenance costs and impact on commercial fishing, it is critical to evaluate their effectiveness to support future conservation. In this paper, we use data collected from the Australian coast to estimate the effect of MPAs on biodiversity. Environmental studies such as these are often observational, and processes of interest exhibit spatial dependence, which presents challenges in estimating the causal effects. Spatial data can also be subject to preferential sampling, where the sampling locations are related to the policy and the response variable, further complicating inference and prediction. To address these challenges, we propose a spatial causal inference method that simultaneously accounts for unmeasured spatial confounders in both the sampling process and the treatment allocation. We prove the identifiability of key parameters in the model and the consistency of the posterior distributions of those parameters. We show via simulation studies that the causal effect of interest can be reliably estimated under the proposed model. The proposed method is applied to assess the effect of MPAs on fish biomass. We find evidence of preferential sampling and that properly accounting for this source of bias impacts the estimate of the causal effect.

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arXiv2026

A nonstationary spatial model of PM2.5 with localized transfer learning from numerical model output

Ambient air pollution measurements from regulatory monitoring networks are routinely used to support epidemiologic studies and environmental policy decision making. However, regulatory monitors are spatially sparse and preferentially located in areas with large populations. Numerical air pollution model output can be leveraged into the inference and prediction of air pollution data combining with measurements from monitors. Nonstationary covariance functions allow the model to adapt to spatial surfaces whose variability changes with location like air pollution data. In the paper, we employ localized covariance parameters learned from the numerical output model to knit together into a global nonstationary covariance, to incorporate in a fully Bayesian model. We model the nonstationary structure in a computationally efficient way to make the Bayesian model scalable.

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arXiv2026

DANCE: Doubly Adaptive Neighborhood Conformal Estimation

The recent developments of complex deep learning models have led to unprecedented ability to accurately predict across multiple data representation types. Conformal prediction for uncertainty quantification of these models has risen in popularity, providing adaptive, statistically-valid prediction sets. For classification tasks, conformal methods have typically focused on utilizing logit scores. For pre-trained models, however, this can result in inefficient, overly conservative set sizes when not calibrated towards the target task. We propose DANCE, a doubly locally adaptive nearest-neighbor based conformal algorithm combining two novel nonconformity scores directly using the data's embedded representation. DANCE first fits a task-adaptive kernel regression model from the embedding layer before using the learned kernel space to produce the final prediction sets for uncertainty quantification. We test against state-of-the-art local, task-adapted and zero-shot conformal baselines, demonstrating DANCE's superior blend of set size efficiency and robustness across various datasets.

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arXiv2026

Density correction for multivariate spatial fields of global climate model output using deep learning

Global Climate Models (GCMs) are numerical models that simulate complex physical processes within the Earth's climate system and are essential for understanding and predicting climate change. However, GCMs suffer from systemic biases due to simplifications made to the underlying physical processes. GCM output therefore needs to be bias corrected before it can be used for future climate projections. Most common bias correction methods, however, cannot preserve spatial, temporal, or inter-variable dependencies. We propose a new semi-parametric estimation of conditional densities (SPECD) approach for density correction of the joint distribution of daily precipitation and maximum temperature data obtained from gridded GCM spatial fields. The Vecchia approximation is employed to preserve dependencies in the observed field during the density correction process, which is carried out using semi-parametric quantile regression. The ability to calibrate joint distributions of GCM projections has potential advantages not only in estimating extremes, but also in better estimating compound hazards, like heat waves and drought, under potential climate change. Illustration on historical data from 1951-2014 over two 5 x 5 spatial grids in the US indicate that SPECD can preserve key marginal and joint distribution properties of precipitation and maximum temperature, and predictions obtained using SPECD are better calibrated compared to predictions using asynchronous quantile mapping and canonical correlation analysis, two commonly used bias correction approaches.

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arXiv2026

A new mixture model for spatiotemporal exceedances with flexible tail dependence

We propose a new model and estimation framework for spatiotemporal streamflow exceedances above a threshold that flexibly captures asymptotic dependence and independence in the tail of the distribution. We model streamflow using a mixture of processes with spatial, temporal and spatiotemporal asymptotic dependence regimes. A censoring mechanism allows us to use only observations above a threshold to estimate marginal and joint probabilities of extreme events. As the likelihood is intractable, we use simulation-based inference powered by random forests to estimate model parameters from summary statistics of the data. Simulations and modeling of streamflow data from the U.S. Geological Survey illustrate the feasibility and practicality of our approach.

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arXiv2026

Demonstrating the power and flexibility of variational assumptions for amortized neural posterior estimation in environmental applications

Classic Bayesian methods with complex models are frequently infeasible due to an intractable likelihood. Simulation-based inference methods, such as Approximate Bayesian Computing (ABC), calculate posteriors without accessing a likelihood function by leveraging the fact that data can be quickly simulated from the model, but converge slowly and/or poorly in high-dimensional settings. In this paper, we propose a framework for Bayesian posterior estimation by mapping data to posteriors of parameters using a neural network trained on data simulated from the complex model. Posterior distributions of model parameters are efficiently obtained by feeding observed data into the trained neural network. We show theoretically that our posteriors converge to the true posteriors in Kullback-Leibler divergence. Our approach yields computationally efficient and theoretically justified uncertainty quantification, which is lacking in existing simulation-based neural network approaches. Comprehensive simulation studies highlight our method's robustness and accuracy.

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arXiv2025

When are novel methods for analyzing complex chemical mixtures in epidemiology beneficial?

Estimating the health impacts of exposure to a mixture of chemicals poses many statistical challenges: multiple correlated exposure variables, moderate to high dimensionality, and possible nonlinear and interactive health effects of mixture components. Reviews of chemical mixture methods aim to help researchers select a statistical method suited to their goals and data, but examinations of empirical performance have emphasized novel methods purpose-built for analyzing complex chemical mixtures, or other more advanced methods, over more general methods which are widely used in many application domains. We conducted a broad experimental comparison, across simulated scenarios, of both more general methods (such as generalized linear models) and novel methods (such as Bayesian Kernel Machine Regression) designed to study chemical mixtures. We assessed methods based on their ability to control Type I error rate, maximize power, provide interpretable results, and make accurate predictions. We find that when there is moderate correlation between mixture components and the exposure-response function does not have complicated interactions, or when mixture components have opposite effects, general methods are preferred over novel ones. With highly interactive exposure-response functions or highly correlated exposures, novel methods provide important benefits. We provide a comprehensive summary of when different methods are most suitable.

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arXiv2025

STACI: Spatio-Temporal Aleatoric Conformal Inference

Fitting Gaussian Processes (GPs) provides interpretable aleatoric uncertainty quantification for estimation of spatio-temporal fields. Spatio-temporal deep learning models, while scalable, typically assume a simplistic independent covariance matrix for the response, failing to capture the underlying correlation structure. However, spatio-temporal GPs suffer from issues of scalability and various forms of approximation bias resulting from restrictive assumptions of the covariance kernel function. We propose STACI, a novel framework consisting of a variational Bayesian neural network approximation of non-stationary spatio-temporal GP along with a novel spatio-temporal conformal inference algorithm. STACI is highly scalable, taking advantage of GPU training capabilities for neural network models, and provides statistically valid prediction intervals for uncertainty quantification. STACI outperforms competing GPs and deep methods in accurately approximating spatio-temporal processes and we show it easily scales to datasets with millions of observations.

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arXiv2025

Causal Spatial Quantile Regression

Treatment effects in a wide range of economic, environmental, and epidemiological applications often vary across space, and understanding the heterogeneity of causal effects across space and outcome quantiles is a critical challenge in spatial causal inference. To effectively capture spatial heterogeneity in distributional treatment effects, we propose a novel semiparametric neural network-based causal framework leveraging deep spatial quantile regression and then construct a plug-in estimator for spatial quantile treatment effects (SQTE). This framework incorporates an efficient adjustment procedure to mitigate the impact of spatial hidden confounders. Extensive simulations across various scenarios demonstrate that our methodology can accurately estimate SQTE, even with the presence of spatial hidden confounders. Additionally, the spatial confounding adjustment procedure effectively reduces neighborhood spatial patterns in the residuals. We apply this method to assess the spatially varying quantile treatment effects of maternal smoking on newborn birth weight in North Carolina, United States. Our findings consistently show negative effects across all birth weight quantiles, with particularly severe impacts observed in the lower quantile regions.

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arXiv2025

Estimating Covariate Effects on Functional Connectivity using Voxel-Level fMRI Data

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard approaches often average signals within regions of interest (ROIs), which ignores the underlying spatiotemporal dependence among voxels and can lead to biased or inefficient inference. We propose to use a summary statistic -- the empirical voxel-wise correlations between ROIs -- and, crucially, model the complex covariance structure among these correlations through a new positive definite covariance function. Building on this foundation, we develop a computationally efficient two-step estimation procedure that enables statistical inference on covariate effects on region-level connectivity. Simulation studies show calibrated uncertainty quantification, and substantial gains in validity of the statistical inference over the standard averaging method. With data from the Autism Brain Imaging Data Exchange, we show that autism spectrum disorder is associated with altered FC between attention-related ROIs after adjusting for age and gender. The proposed framework offers an interpretable and statistically rigorous approach to estimation of covariate effects on FC suitable for large-scale neuroimaging studies.

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arXiv2025

Two-stage Estimators for Spatial Confounding with Point-Referenced Data

Public health data are often spatially dependent, but standard spatial regression methods can suffer from bias and invalid inference when the independent variable is associated with spatially-correlated residuals. This could occur if, for example, there is an unmeasured environmental contaminant associated with the independent and outcome variables in a spatial regression analysis. Geoadditive structural equation modeling (gSEM), in which an estimated spatial trend is removed from both the explanatory and response variables before estimating the parameters of interest, has previously been proposed as a solution, but there has been little investigation of gSEM's properties with point-referenced data. We link gSEM to results on double machine learning and semiparametric regression based on two-stage procedures. We propose using these semiparametric estimators for spatial regression using Gaussian processes with Matèrn covariance to estimate the spatial trends, and term this class of estimators Double Spatial Regression (DSR). We derive regularity conditions for root-$n$ asymptotic normality and consistency and closed-form variance estimation, and show that in simulations where standard spatial regression estimators are highly biased and have poor coverage, DSR can mitigate bias more effectively than competitors and obtain nominal coverage.

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arXiv2025

Semiparametric Estimation of the Shape of the Limiting Bivariate Point Cloud

We propose a model to flexibly estimate joint tail properties by exploiting the convergence of an appropriately scaled point cloud onto a compact limit set. Characteristics of the shape of the limit set correspond to key tail dependence properties. We directly model the shape of the limit set using Bezier splines, which allow flexible and parsimonious specification of shapes in two dimensions. We fit the Bezier splines to data in pseudo-polar coordinates using Markov chain Monte Carlo sampling, utilizing a limiting approximation to the conditional likelihood of the radii given angles. We propose a novel prior on the shape of the limit set via constraints on the parameters of the Bezier splines. A direct advantage of our Bayesian approach is that the support of this prior guarantees that each posterior sample is a valid limit set boundary, allowing direct posterior analysis of any quantity derived from the shape of the curve. Furthermore, we obtain interpretable inference on the asymptotic dependence class by using mixture priors with point masses on the corner of the unit box. Finally, we apply our model to bivariate datasets of extremes of variables related to fire risk and air pollution.

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arXiv2024

A Two-Stage Approach for Segmenting Spatial Point Patterns Applied to Multiplex Imaging

Recent advances in multiplex imaging have enabled researchers to locate different types of cells within a tissue sample. This is especially relevant for tumor immunology, as clinical regimes corresponding to different stages of disease or responses to treatment may manifest as different spatial arrangements of tumor and immune cells. Spatial point pattern modeling can be used to partition multiplex tissue images according to these regimes. To this end, we propose a two-stage approach: first, local intensities and pair correlation functions are estimated from the spatial point pattern of cells within each image, and the pair correlation functions are reduced in dimension via spectral decomposition of the covariance function. Second, the estimates are clustered in a Bayesian hierarchical model with spatially-dependent cluster labels. The clusters correspond to regimes of interest that are present across subjects; the cluster labels segment the spatial point patterns according to those regimes. Through Markov Chain Monte Carlo sampling, we jointly estimate and quantify uncertainty in the cluster assignment and spatial characteristics of each cluster. Simulations demonstrate the performance of the method, and it is applied to a set of multiplex immunofluorescence images of diseased pancreatic tissue.

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arXiv2024

Multivariate and Online Transfer Learning with Uncertainty Quantification

Untreated periodontitis causes inflammation within the supporting tissue of the teeth and can ultimately lead to tooth loss. Modeling periodontal outcomes is beneficial as they are difficult and time consuming to measure, but disparities in representation between demographic groups must be considered. There may not be enough participants to build group specific models and it can be ineffective, and even dangerous, to apply a model to participants in an underrepresented group if demographic differences were not considered during training. We propose an extension to RECaST Bayesian transfer learning framework. Our method jointly models multivariate outcomes, exhibiting significant improvement over the previous univariate RECaST method. Further, we introduce an online approach to model sequential data sets. Negative transfer is mitigated to ensure that the information shared from the other demographic groups does not negatively impact the modeling of the underrepresented participants. The Bayesian framework naturally provides uncertainty quantification on predictions. Especially important in medical applications, our method does not share data between domains. We demonstrate the effectiveness of our method in both predictive performance and uncertainty quantification on simulated data and on a database of dental records from the HealthPartners Institute.

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arXiv2024

Mediation analysis of community context effects on heart failure using the survival R2D2 prior

Congestive heart failure (CHF) is a leading cause of morbidity, mortality and healthcare costs, impacting $>$23 million individuals worldwide. Large electronic health records data provide an opportunity to improve clinical management of diseases, but statistical inference on large amounts of relevant personal data is still challenging. Thus, accurately identifying influential risk factors is pivotal to reducing information dimensionality. Bayesian variable selection in survival regression is a common approach towards solving this problem. Here, we propose placing a beta prior directly on the model coefficient of determination (Bayesian $R^2$), which induces a prior on the global variance of the predictors and provides shrinkage. Through reparameterization using an auxiliary variable, we are able to update a majority of the parameters with Gibbs sampling, simplifying computation and quickening convergence. Performance gains over competing variable selection methods are showcased through an extensive simulation study. Finally, the method is applied in a mediation analysis to identify community context attributes impacting time to first congestive heart failure diagnosis of patients enrolled in University of North Carolina Cardiovascular Device Surveillance Registry. The model has high predictive performance and we find that factors associated with higher socioeconomic inequality increase risk of heart failure.

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arXiv2024

Amortized Bayesian Local Interpolation NetworK: Fast covariance parameter estimation for Gaussian Processes

Gaussian processes (GPs) are a ubiquitous tool for geostatistical modeling with high levels of flexibility and interpretability, and the ability to make predictions at unseen spatial locations through a process called Kriging. Estimation of Kriging weights relies on the inversion of the process' covariance matrix, creating a computational bottleneck for large spatial datasets. In this paper, we propose an Amortized Bayesian Local Interpolation NetworK (A-BLINK) for fast covariance parameter estimation, which uses two pre-trained deep neural networks to learn a mapping from spatial location coordinates and covariance function parameters to Kriging weights and the spatial variance, respectively. The fast prediction time of these networks allows us to bypass the matrix inversion step, creating large computational speedups over competing methods in both frequentist and Bayesian settings, and also provides full posterior inference and predictions using Markov chain Monte Carlo sampling methods. We show significant increases in computational efficiency over comparable scalable GP methodology in an extensive simulation study with lower parameter estimation error. The efficacy of our approach is also demonstrated using a temperature dataset of US climate normals for 1991--2020 based on over 7,000 weather stations.

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arXiv2024

Estimating spatially varying health effects of wildland fire smoke using mobile health data

Wildland fire smoke exposures are an increasing threat to public health, and thus there is a growing need for studying the effects of protective behaviors on reducing health outcomes. Emerging smartphone applications provide unprecedented opportunities to deliver health risk communication messages to a large number of individuals when and where they experience the exposure and subsequently study the effectiveness, but also pose novel methodological challenges. Smoke Sense, a citizen science project, provides an interactive smartphone app platform for participants to engage with information about air quality and ways to protect their health and record their own health symptoms and actions taken to reduce smoke exposure. We propose a new, doubly robust estimator of the structural nested mean model parameter that accounts for spatially- and time-varying effects via a local estimating equation approach with geographical kernel weighting. Moreover, our analytical framework is flexible enough to handle informative missingness by inverse probability weighting of estimating functions. We evaluate the new method using extensive simulation studies and apply it to Smoke Sense data reported by the citizen scientists to increase the knowledge base about the relationship between health preventive measures and improved health outcomes. Our results estimate how the protective behaviors effects vary over space and time and find that protective behaviors have more significant effects on reducing health symptoms in the Southwest than the Northwest region of the USA.

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arXiv2024

A Bayesian shrinkage estimator for transfer learning

Transfer learning (TL) has emerged as a powerful tool to supplement data collected for a target task with data collected for a related source task. The Bayesian framework is natural for TL because information from the source data can be incorporated in the prior distribution for the target data analysis. In this paper, we propose and study Bayesian TL methods for the normal-means problem and multiple linear regression. We propose two classes of prior distributions. The first class assumes the difference in the parameters for the source and target tasks is sparse, i.e., many parameters are shared across tasks. The second assumes that none of the parameters are shared across tasks, but the differences are bounded in $\ell_2$-norm. For the sparse case, we propose a Bayes shrinkage estimator with theoretical guarantees under mild assumptions. The proposed methodology is tested on synthetic data and outperforms state-of-the-art TL methods. We then use this method to fine-tune the last layer of a neural network model to predict the molecular gap property in a material science application. We report improved performance compared to classical fine tuning and methods using only the target data.

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