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Bruno Pereira

Publications and source records attributed to Bruno Pereira.

2 recordsLinked to original sources

The NetMob26 Dataset: A High-Resolution Multi-Source View of Public Bus Mobility in Niter\'oi

The NetMob Data Challenge releases a comprehensive public transportation dataset from Niter\'oi, addressing the lack of high-quality mobility and passenger demand data. Based on operational records from March 2026, the dataset combines four main sources: GPS telemetry from buses, approximately 7.2 million ticketing transactions, auxiliary transit data (routes, stops, and weather), and urban infrastructure and socio-demographic information. Together, these sources provide a detailed view of both transit supply and passenger demand. The data were preprocessed, cleaned, and anonymized to preserve privacy and improve reliability, including the removal of operational inconsistencies and anonymization of passenger identifiers. Access is restricted to challenge participants who accept the Terms and Conditions and sign an NDA. The paper describes the data collection and preprocessing pipeline, dataset organization, and mobility patterns observed in the system. The dataset supports research on topics such as public transportation efficiency, demand forecasting, accessibility analysis, service reliability, and the influence of external factors like weather on urban mobility.

physics.soc-ph

The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR were associated with higher grades of glioma, particularly IDH wild-type cases. Mechanistically, HOTAIR was overexpressed in a gene dosage-independent manner, while DNA methylation levels of particular CpGs in HOTAIR locus were associated with HOTAIR expression levels in GBM clinical specimens and cell lines. Concordantly, the demethylating agent 5-Aza-2'-deoxycytidine affected HOTAIR transcriptional levels in a cell line-dependent manner. Importantly, HOTAIR was frequently co-expressed with HOXA9 in high-grade gliomas from TCGA, Oncomine, and our Portuguese and French datasets. Integrated in silico analyses, chromatin immunoprecipitation, and qPCR data showed that HOXA9 binds directly to the promoter of HOTAIR. Clinically, GBM patients with high HOTAIR expression had a significantly reduced overall survival, independently of other prognostic variables. In summary, this work reveals HOXA9 as a novel direct regulator of HOTAIR, and establishes HOTAIR as an independent prognostic marker, providing new therapeutic opportunities to treat this highly aggressive cancer.

q-bio.GN