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Bryan L. Lewis

Publications and source records attributed to Bryan L. Lewis.

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EpiNarrate: Agentic Generation of Grounded Narratives from Epidemiological Scenario Projections

Generation of clear and accessible public health narratives is critical for communicating complex epidemiological projections to policymakers and the general public at large. Such narratives require more than simply reporting numbers: projections must be contextualized and quantitatively grounded across multiple dimensions. Further, projections are often derived from large ensemble datasets which combine intervention assumptions, geographic and demographic strata, outcomes, time horizons, and uncertainty quantiles. However, directly using large language models (LLMs) to summarize and contextualize such data often leads to inconsistencies, omissions, and fragile behavior. We introduce an agentic framework (EpiNarrate) for public health report generation that separates structured numerical reasoning from natural-language generation. The framework first extracts scenario axes and organizes them into a partial-order schema, enabling systematic traversal of the underlying multidimensional space. It then constructs an augmented dataset and derives valid quantitative statements through a comparison grammar that enforces semantic and arithmetic consistency. To balance coverage and non-redundancy, we introduce an interestingness-driven selection mechanism based on maximum-entropy principles. Experiments on the COVID-19 Scenario Modeling Hub demonstrate that our model produces narratives with improved factual grounding and broader coverage of salient epidemiological patterns, while preserving the style of expert-written reports.

cs.CL

Guided Deep List: Automating the Generation of Epidemiological Line Lists from Open Sources

Real-time monitoring and responses to emerging public health threats rely on the availability of timely surveillance data. During the early stages of an epidemic, the ready availability of line lists with detailed tabular information about laboratory-confirmed cases can assist epidemiologists in making reliable inferences and forecasts. Such inferences are crucial to understand the epidemiology of a specific disease early enough to stop or control the outbreak. However, construction of such line lists requires considerable human supervision and therefore, difficult to generate in real-time. In this paper, we motivate Guided Deep List, the first tool for building automated line lists (in near real-time) from open source reports of emerging disease outbreaks. Specifically, we focus on deriving epidemiological characteristics of an emerging disease and the affected population from reports of illness. Guided Deep List uses distributed vector representations (ala word2vec) to discover a set of indicators for each line list feature. This discovery of indicators is followed by the use of dependency parsing based techniques for final extraction in tabular form. We evaluate the performance of Guided Deep List against a human annotated line list provided by HealthMap corresponding to MERS outbreaks in Saudi Arabia. We demonstrate that Guided Deep List extracts line list features with increased accuracy compared to a baseline method. We further show how these automatically extracted line list features can be used for making epidemiological inferences, such as inferring demographics and symptoms-to-hospitalization period of affected individuals.

cs.CL

The Potential Impact of Increased Hospital Capacity to Contain and Control Ebola in Liberia

West Africa is currently experiencing a severe outbreak of Ebola virus disease (EVD). As part of the international effort to address this outbreak, the United States has committed to building specialized Ebola treatment facilities with 1700 beds. However, the effectiveness of this increase in the available healthcare facilities to treat Ebola is unclear, especially in light of the rapidly increasing number of cases. Adapting a previously validated mathematical model of Ebola in West Africa, we examine the potential impact of an increase in hospital capacity to mitigate the impact of Ebola under several scenarios, ranging from the planned scenario of 1700 beds in 10 weeks to a considerably more aggressive approach of twice the number of beds in 5 weeks. We find that even for the most aggressive scenarios, while increasing the availability of healthcare reduces the number of Ebola cases and slows the outbreak, it is not sufficient to stop the epidemic within the next three months. We find that only a combination of increased hospital beds and a dramatic decrease in the rate of transmission within the community can bring the epidemic under control within the near future.

q-bio.PE

Modeling the Impact of Interventions on an Epidemic of Ebola in Sierra Leone and Liberia

An Ebola outbreak of unparalleled size is currently affecting several countries in West Africa, and international efforts to control the outbreak are underway. However, the efficacy of these interventions, and their likely impact on an Ebola epidemic of this size, is unknown. Forecasting and simulation of these interventions may inform public health efforts. We use existing data from Liberia and Sierra Leone to parameterize a mathematical model of Ebola and use this model to forecast the progression of the epidemic, as well as the efficacy of several interventions, including increased contact tracing, improved infection control practices, the use of a hypothetical pharmaceutical intervention to improve survival in hospitalized patients. Model forecasts until Dec. 31, 2014 show an increasingly severe epidemic with no sign of having reached a peak. Modeling results suggest that increased contact tracing, improved infection control, or a combination of the two can have a substantial impact on the number of Ebola cases, but these interventions are not sufficient to halt the progress of the epidemic. The hypothetical pharmaceutical intervention, while impacting mortality, had a smaller effect on the forecasted trajectory of the epidemic. Near-term, practical interventions to address the ongoing Ebola epidemic may have a beneficial impact on public health, but they will not result in the immediate halting, or even obvious slowing of the epidemic. A long-term commitment of resources and support will be necessary to address the outbreak.

q-bio.PE