Buzz Baum | Searcharxiv

arXiv2025

A non-reciprocal model for morphogenesis in symbiosis

The shape of a cell influences, and it is influenced by its interactions with its neighbours. Here, we introduce a coarse-grained computational model of non-reciprocal interactions between single-cell organisms to study emergent morphologies during symbiotic association. We show that the cell membrane can be remodelled into branched protrusions, invaginations, transient blebs and other dynamical morphologies that depend on the number of interacting partners, the asymmetry, and the magnitude of partnership activity. Our model finds a dynamical feedback between the local deformation of the membrane and its driving force, leading to membrane morphologies not reported in reciprocal systems with constant activity.

cond-mat.soft↗

arXiv2013

Cooperation and competition in the dynamics of tissue architecture during homeostasis and tumorigenesis

The construction of a network of cell-to-cell contacts makes it possible to characterize the patterns and spatial organisation of tissues. Such networks are highly dynamic, depending on the changes of the tissue architecture caused by cell division, death and migration. Local competitive and cooperative cell-to-cell interactions influence the choices cells make. We review the literature on quantitative data of epithelial tissue topology and present a dynamical network model that can be used to explore the evolutionary dynamics of a two dimensional tissue architecture with arbitrary cell-to-cell interactions. In particular, we show that various forms of experimentally observed types of interactions can be modelled using game theory. We discuss a model of cooperative and non-cooperative cell-to-cell communication that can capture the interplay between cellular competition and tissue dynamics. We conclude with an outlook on the possible uses of this approach in modelling tumorigenesis and tissue homeostasis.

q-bio.TO↗