C. C. Wood | Searcharxiv

arXiv2006

Modeling spatiotemporal noise covariance for MEG/EEG source analysis

We propose a new model for approximating spatiotemporal noise covariance for use in MEG/EEG source analysis. Our model is an extension of an existing model [1,2] that uses a single Kronecker product of a pair of matrices - temporal and spatial covariance; we employ a series of Kronecker products in order to construct a better approximation of the full covariance. In contrast to the single-pair model that assumes the same temporal structure for all spatial components, the proposed model allows for distinct, independent time courses at each spatial component. This model better describes spatially and temporally correlated background activity. At the same time, inversion of the model is fast which makes it useful in the inverse analysis. We have explored two versions of the model. One is based on orthogonal spatial components of the background. The other, more general model, is based on independent spatial components. Performance of the new and previous models is compared in inverse solutions to a large number of single dipole problems with simulated time courses and background from authentic MEG data.

physics.data-an↗

arXiv1998

Bayesian Inference Applied to the Electromagnetic Inverse Problem

We present a new approach to the electromagnetic inverse problem that explicitly addresses the ambiguity associated with its ill-posed character. Rather than calculating a single ``best'' solution according to some criterion, our approach produces a large number of likely solutions that both fit the data and any prior information that is used. While the range of the different likely results is representative of the ambiguity in the inverse problem even with prior information present, features that are common across a large number of the different solutions can be identified and are associated with a high degree of probability. This approach is implemented and quantified within the formalism of Bayesian inference which combines prior information with that from measurement in a common framework using a single measure. To demonstrate this approach, a general neural activation model is constructed that includes a variable number of extended regions of activation and can incorporate a great deal of prior information on neural current such as information on location, orientation, strength and spatial smoothness. Taken together, this activation model and the Bayesian inferential approach yield estimates of the probability distributions for the number, location, and extent of active regions. Both simulated MEG data and data from a visual evoked response experiment are used to demonstrate the capabilities of this approach.

q-bio.NC↗