arXiv subjects

C. Wendt

Publications and source records attributed to C. Wendt.

9 recordsLinked to original sources

arXiv2024

The Design and Construction of the Chips Water Cherenkov Neutrino Detector

CHIPS (CHerenkov detectors In mine PitS) was a prototype large-scale water Cherenkov detector located in northern Minnesota. The main aim of the R&D project was to demonstrate that construction costs of neutrino oscillation detectors could be reduced by at least an order of magnitude compared to other equivalent experiments. This article presents design features of the CHIPS detector along with details of the implementation and deployment of the prototype. While issues during and after the deployment of the detector prevented data taking, a number of key concepts and designs were successfully demonstrated.

physics.ins-det↗

arXiv2023

Extensions of Heterogeneity in Integration and Prediction (HIP) with R Shiny Application

Multiple data views measured on the same set of participants is becoming more common and has the potential to deepen our understanding of many complex diseases by analyzing these different views simultaneously. Equally important, many of these complex diseases show evidence of subgroup heterogeneity (e.g., by sex or race). HIP (Heterogeneity in Integration and Prediction) is among the first methods proposed to integrate multiple data views while also accounting for subgroup heterogeneity to identify common and subgroup-specific markers of a particular disease. However, HIP is applicable to continuous outcomes and requires programming expertise by the user. Here we propose extensions to HIP that accommodate multi-class, Poisson, and Zero-Inflated Poisson outcomes while retaining the benefits of HIP. Additionally, we introduce an R Shiny application, accessible on shinyapps.io at https://multi-viewlearn.shinyapps.io/HIP_ShinyApp/, that provides an interface with the Python implementation of HIP to allow more researchers to use the method anywhere and on any device. We applied HIP to identify genes and proteins common and specific to males and females that are associated with exacerbation frequency. Although some of the identified genes and proteins show evidence of a relationship with chronic obstructive pulmonary disease (COPD) in existing literature, others may be candidates for future research investigating their relationship with COPD. We demonstrate the use of the Shiny application with a publicly available data. An R-package for HIP would be made available at https://github.com/lasandrall/HIP.

stat.ME↗

arXiv2021

Accounting for data heterogeneity in integrative analysis and prediction methods: An application to Chronic Obstructive Pulmonary Disease

Epidemiologic and genetic studies in chronic obstructive pulmonary disease (COPD) and many complex diseases suggest subgroup disparities (e.g., by sex). We consider this problem from the standpoint of integrative analysis where we combine information from different views (e.g., genomics, proteomics, clinical data). Existing integrative analysis methods ignore the heterogeneity in subgroups, and stacking the views and accounting for subgroup heterogeneity does not model the association among the views. To address analytical challenges in the problem of our interest, we propose a statistical approach for joint association and prediction that leverages the strengths in each view to identify molecular signatures that are shared by and specific to males and females and that contribute to the variation in COPD, measured by airway wall thickness. HIP (Heterogeneity in Integration and Prediction) accounts for subgroup heterogeneity, allows for sparsity in variable selection, is applicable to multi-class and to univariate or multivariate continuous outcomes, and incorporates covariate adjustment. We develop efficient algorithms in PyTorch. Our COPD findings have identified several proteins, genes, and pathways that are common and specific to males and females, some of which have been implicated in COPD, while others could lead to new insights into sex differences in COPD mechanisms.

stat.ME↗

arXiv2021

Robust Integrative Biclustering for Multi-view Data

In many biomedical research, multiple views of data (e.g., genomics, proteomics) are available, and a particular interest might be the detection of sample subgroups characterized by specific groups of variables. Biclustering methods are well-suited for this problem as they assume that specific groups of variables might be relevant only to specific groups of samples. Many biclustering methods exist for identifying row-column clusters in a view but few methods exist for data from multiple views. The few existing algorithms are heavily dependent on regularization parameters for getting row-column clusters, and they impose unnecessary burden on users thus limiting their use in practice. We extend an existing biclustering method based on sparse singular value decomposition for single-view data to data from multiple views. Our method, integrative sparse singular value decomposition (iSSVD), incorporates stability selection to control Type I error rates, estimates the probability of samples and variables to belong to a bicluster, finds stable biclusters, and results in interpretable row-column associations. Simulations and real data analyses show that iSSVD outperforms several other single- and multi-view biclustering methods and is able to detect meaningful biclusters. iSSVD is a user-friendly, computationally efficient algorithm that will be useful in many disease subtyping applications.

stat.ME↗

arXiv2021

Design and performance of the multi-PMT optical module for IceCube Upgrade

The IceCube Upgrade is the first step towards the next-generation neutrino observatory at the South Pole, IceCube-Gen2, and will be installed in the central region of the existing array. The Upgrade will consist of 693 newly developed, densely spaced optical sensors and 50 standalone calibration devices, which will enhance IceCube's capabilities both at low and high neutrino energies. Of the new sensors, 402 will be multi-PMT Digital Optical Modules (mDOMs). Consisting of 24 small photomultipliers arranged inside a pressure vessel, the mDOM features a large sensitive area distributed nearly homogeneously over the full solid angle. The use of multiple, individually read-out PMTs allows directional information to be obtained for the registered photons and enables the use of multiplicity triggering within a single module, e.g., for background suppression. The challenges driving the mDOM development included tight restrictions on module size, data-transfer rate, and power consumption as well as the harsh environment in the deep ice at the South Pole. In this contribution we present the final mDOM design that meets these challenges.

astro-ph.IM↗

arXiv2019

Characterization of the HZC Photonics XP82B20D and XP1805D Photomultiplier Tubes for Low-Temperature Applications

The IceCube Collaboration is investigating various types and manufacturers of photomultiplier tubes (PMT) for possible use in future optical modules. This report presents characterization results for two different types of HZC Photonics PMTs: the 3.5 inch XP82B20D and the 9 inch XP1805D. The results are in good agreement with the specifications as provided by the manufacturer. In addition, excellent noise behaviour is observed at the low temperatures relevant for possible use in IceCube optical modules.

physics.ins-det↗

arXiv2016

Measuring the Attenuation Length of Water in the CHIPS-M Water Cherenkov Detector

The water at the proposed site of the CHIPS water Cherenkov detector has been studied to measure its attenuation length for Cherenkov light as a function of filtering time. A scaled model of the CHIPS detector filled with water from the Wentworth 2W pit, proposed site of the CHIPS deployment, in conjunction with a 3.2\unit{m} vertical column filled with this water, was used to study the transmission of 405nm laser light. Results consistent with attenuation lengths of up to 100m were observed for this wavelength with filtration and UV sterilization alone.

physics.ins-det↗

arXiv2013

CHerenkov detectors In mine PitS (CHIPS) Letter of Intent to FNAL

This Letter of Intent outlines a proposal to build a large, yet cost-effective, 100 kton fiducial mass water Cherenkov detector that will initially run in the NuMI beam line. The CHIPS detector (CHerenkov detector In Mine PitS) will be deployed in a flooded mine pit, removing the necessity and expense of a substantial external structure capable of supporting a large detector mass. There are a number of mine pits in northern Minnesota along the NuMI beam that could be used to deploy such a detector. In particular, the Wentworth Pit 2W is at the ideal off-axis angle to contribute to the measurement of the CP violating phase. The detector is designed so that it can be moved to a mine pit in the LBNE beam line once that becomes operational.

physics.ins-det↗

arXiv1995

ANOMALOUS GAUGE BOSON INTERACTIONS

We discuss the direct measurement of the trilinear vector boson couplings in present and future collider experiments. The major goals of such experiments will be the confirmation of the Standard Model (SM) predictions and the search for signals of new physics. We review our current theoretical understanding of anomalous trilinear gauge boson self-interactions. If the energy scale of the new physics is $\sim 1$ TeV, these low energy anomalous couplings are expected to be no larger than ${\cal O}(10^{-2})$. Constraints from high precision measurements at LEP and low energy charged and neutral current processes are critically reviewed.

hep-ph↗