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Candy Sonveaux

Publications and source records attributed to Candy Sonveaux.

4 recordsLinked to original sources

An Age-Structured Vaccination Strategy for Epidemic Containment: A Model Predictive Control Approach

This work presents a novel Model Predictive Control (MPC) approach to develop an optimal age-structured vaccination strategy for the containment of COVID-19 in Wallonia, Belgium. The proposed MPC framework is designed to minimize deaths, achieve early disease eradication, and adhere to operational constraints. By incorporating an age-structured Susceptible-Infected-Recovered-Deceased (SIRD) model with an additional term for vaccination, the MPC strategy dynamically adapts to the evolving epidemic state. A detailed proof of the asymptotic stability and recursive feasibility of the proposed MPC algorithm is provided. This ensures that the optimal cost at each step provides an upper bound on the minimal number obtainable of deaths at the end of the pandemic. Moreover, simulations demonstrate that the proposed MPC approach outperforms the decreasing age vaccination strategy adopted by the Belgian government during the first wave of vaccinations. The results highlight the potential of MPC-based vaccination strategies to reduce the total number of deaths, accelerate disease eradication, and optimize vaccine administration.

math.OC

Observer-based output feedback for an age-structured SIRD model

An age-structured Susceptible-Infected-Recovered-Deceased (SIRD) epidemic model is considered. The aim of this paper is to design an observer-based output feedback control law, representing an immunization process, typically vaccination, intended to decrease the peak of infected individuals in the population. At first, well-posedness and stability of the system in open-loop are investigated. Then, to obtain the observer-based output feedback law, a state feedback law is designed by using a normal form. Conditions to ensure stability are established. However, due to physical constraints, this law needs to be adapted. Therefore, a constrained state-feedback law is implemented. This law is designed to fulfill the physical constraints while having good properties (Lipschitz for instance), needed for the last part of the article. Finally, an observer-based output feedback law is obtained using high-gain observer. At each step of the design, convergence properties are obtained. Finally, numerical simulations are performed.

math.OC

State feedback control law design for an age-dependent SIR model

An age-dependent SIR model is considered with the aim to develop a state-feedback vaccination law in order to eradicate a disease. A dynamical analysis of the system is performed using the principle of linearized stability and shows that, if the basic reproduction number is larger than 1, the disease free equilibrium is unstable. This result justifies the developement of a vaccination law. Two approaches are used. The first one is based on a dicretization of the partial integro-differential equations (PIDE) model according to the age. In this case a linearizing feedback law is found using Isidori's theory. Conditions guaranteeing stability and positivity are established. The second approach yields a linearizing feedback law developed for the PIDE model. This law is deduced from the one obtained for the ODE case. Using semigroup theory, stability conditions are also obtained. Finally, numerical simulations are presented to reinforce the theoretical arguments.

math.OC