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Carlos Martín

Publications and source records attributed to Carlos Martín.

2 recordsLinked to original sources

Modelling the three-dimensional, diagnostic anisotropy field of an ice rise

Polar ice develops anisotropic crystal orientation fabrics under deformation, yet ice is most often modelled as an isotropic fluid. We present three-dimensional simulations of the crystal orientation fabric of Derwael Ice Rise including the surrounding ice shelf using a crystal orientation tensor evolution equation corresponding to a fixed velocity field. We use a semi-Lagrangian numerical method that constrains the degree of crystal orientation evolution to solve the equations in complex flow areas. We perform four simulations based on previous studies, altering the rate of evolution of the crystal anisotropy and its dependence on a combination of the strain rate and deviatoric stress tensors. We provide a framework for comparison with radar observations of the anisotropy field, outlining areas where the assumption of one vertical eigenvector may not hold and provide resulting errors in measured eigenvalues. We recognise the areas of high horizontal divergence at the ends of the flow divide as important areas to make comparisons with observations. Here, poorly constrained model parameters result in the largest difference in fabric type. These results are important in the planning of future campaigns for gathering data to constrain model parameters and as a link between observations and computationally-efficient, simplified models of anisotropy.

physics.flu-dyn↗

On the impact of Masking and Blocking Hypotheses for measuring efficacy of new tuberculosis vaccines

Over the past 60 years, the Mycobacterium bovis bacille Calmette-Guérin (BCG) has been used worldwide to prevent tuberculosis (TB). However, BCG has shown a very variable efficacy in different trials, showing a wide range of protection in adults against pulmonary TB. Previous studies indicate that this failure is related to pre-existing immune response to antigens that are common to environmental sources of mycobacterial antigens and Mycobacterium tuberculosis. Specifically, two different mechanisms have been hypothesized: the masking, (previous sensitization confers some level of protection against TB), and the blocking (previous immune response prevent vaccine taking of a new TB vaccine), effects. In this work we introduce a series of models to discriminate between masking and blocking mechanisms and address their relative likelihood. The application of our models to interpret the results coming from the BCG-REVAC clinical trials, specifically designed for the study of sources of efficacy variability yields estimates that are consistent with high levels of blocking (41% in Manaus -95% C.I. [14%-68%]- and 96% in Salvador -95% C.I. [52%-100%]-), and no support for masking to play any relevant role in modifying vaccine efficacy either alone or aside blocking. The quantification of these effects around a plausible model constitutes a relevant step towards impact evaluation of novel anti-tuberculosis vaccines, which are susceptible of being affected by similar effects if applied on individuals previously exposed to mycobacterial antigens.

q-bio.PE↗