arXiv subjects

Catherine Matias

Publications and source records attributed to Catherine Matias.

28 records · Page 2Linked to original sources

arXiv2013

On efficient estimators of the proportion of true null hypotheses in a multiple testing setup

We consider the problem of estimating the proportion $θ$ of true null hypotheses in a multiple testing context. The setup is classically modeled through a semiparametric mixture with two components: a uniform distribution on interval $[0,1]$ with prior probability $θ$ and a nonparametric density $f$. We discuss asymptotic efficiency results and establish that two different cases occur whether $f$ vanishes on a set with non null Lebesgue measure or not. In the first case, we exhibit estimators converging at parametric rate, compute the optimal asymptotic variance and conjecture that no estimator is asymptotically efficient (i.e. attains the optimal asymptotic variance). In the second case, we prove that the quadratic risk of any estimator does not converge at parametric rate. We illustrate those results on simulated data.

stat.AP↗

arXiv2012

Maximum likelihood estimator consistency for ballistic random walk in a parametric random environment

We consider a one dimensional ballistic random walk evolving in an i.i.d. parametric random environment. We provide a maximum likelihood estimation procedure of the environment parameters based on a single observation of the path till the time it reaches a distant site, and prove that this estimator is consistent as the distant site tends to infinity. We also explore the numerical performances of our estimation procedure.

math.ST↗

arXiv2011

A context dependent pair hidden Markov model for statistical alignment

This article proposes a novel approach to statistical alignment of nucleotide sequences by introducing a context dependent structure on the substitution process in the underlying evolutionary model. We propose to estimate alignments and context dependent mutation rates relying on the observation of two homologous sequences. The procedure is based on a generalized pair-hidden Markov structure, where conditional on the alignment path, the nucleotide sequences follow a Markov distribution. We use a stochastic approximation expectation maximization (saem) algorithm to give accurate estimators of parameters and alignments. We provide results both on simulated data and vertebrate genomes, which are known to have a high mutation rate from CG dinucleotide. In particular, we establish that the method improves the accuracy of the alignment of a human pseudogene and its functional gene.

math.ST↗

arXiv2010

New consistent and asymptotically normal estimators for random graph mixture models

Random graph mixture models are now very popular for modeling real data networks. In these setups, parameter estimation procedures usually rely on variational approximations, either combined with the expectation-maximisation (\textsc{em}) algorithm or with Bayesian approaches. Despite good results on synthetic data, the validity of the variational approximation is however not established. Moreover, the behavior of the maximum likelihood or of the maximum a posteriori estimators approximated by these procedures is not known in these models, due to the dependency structure on the variables. In this work, we show that in many different affiliation contexts (for binary or weighted graphs), estimators based either on moment equations or on the maximization of some composite likelihood are strongly consistent and $\sqrt{n}$-convergent, where $n$ is the number of nodes. As a consequence, our result establishes that the overall structure of an affiliation model can be caught by the description of the network in terms of its number of triads (order 3 structures) and edges (order 2 structures). We illustrate the efficiency of our method on simulated data and compare its performances with other existing procedures. A data set of cross-citations among economics journals is also analyzed.

math.ST↗

arXiv2010

Parameter identifiability in a class of random graph mixture models

We prove identifiability of parameters for a broad class of random graph mixture models. These models are characterized by a partition of the set of graph nodes into latent (unobservable) groups. The connectivities between nodes are independent random variables when conditioned on the groups of the nodes being connected. In the binary random graph case, in which edges are either present or absent, these models are known as stochastic blockmodels and have been widely used in the social sciences and, more recently, in biology. Their generalizations to weighted random graphs, either in parametric or non-parametric form, are also of interest in many areas. Despite a broad range of applications, the parameter identifiability issue for such models is involved, and previously has only been touched upon in the literature. We give here a thorough investigation of this problem. Our work also has consequences for parameter estimation. In particular, the estimation procedure proposed by Frank and Harary for binary affiliation models is revisited in this article.

math.ST↗

arXiv2009

Identifiability of parameters in latent structure models with many observed variables

While hidden class models of various types arise in many statistical applications, it is often difficult to establish the identifiability of their parameters. Focusing on models in which there is some structure of independence of some of the observed variables conditioned on hidden ones, we demonstrate a general approach for establishing identifiability utilizing algebraic arguments. A theorem of J. Kruskal for a simple latent-class model with finite state space lies at the core of our results, though we apply it to a diverse set of models. These include mixtures of both finite and nonparametric product distributions, hidden Markov models and random graph mixture models, and lead to a number of new results and improvements to old ones. In the parametric setting, this approach indicates that for such models, the classical definition of identifiability is typically too strong. Instead generic identifiability holds, which implies that the set of nonidentifiable parameters has measure zero, so that parameter inference is still meaningful. In particular, this sheds light on the properties of finite mixtures of Bernoulli products, which have been used for decades despite being known to have nonidentifiable parameters. In the nonparametric setting, we again obtain identifiability only when certain restrictions are placed on the distributions that are mixed, but we explicitly describe the conditions.

math.ST↗

arXiv2008

Inferring sparse Gaussian graphical models with latent structure

Our concern is selecting the concentration matrix's nonzero coefficients for a sparse Gaussian graphical model in a high-dimensional setting. This corresponds to estimating the graph of conditional dependencies between the variables. We describe a novel framework taking into account a latent structure on the concentration matrix. This latent structure is used to drive a penalty matrix and thus to recover a graphical model with a constrained topology. Our method uses an $\ell_1$ penalized likelihood criterion. Inference of the graph of conditional dependencies between the variates and of the hidden variables is performed simultaneously in an iterative \textsc{em}-like algorithm. The performances of our method is illustrated on synthetic as well as real data, the latter concerning breast cancer.

stat.ME↗

arXiv2008

Adaptivity in convolution models with partially known noise distribution

We consider a semiparametric convolution model. We observe random variables having a distribution given by the convolution of some unknown density $f$ and some partially known noise density $g$. In this work, $g$ is assumed exponentially smooth with stable law having unknown self-similarity index $s$. In order to ensure identifiability of the model, we restrict our attention to polynomially smooth, Sobolev-type densities $f$, with smoothness parameter $β$. In this context, we first provide a consistent estimation procedure for $s$. This estimator is then plugged-into three different procedures: estimation of the unknown density $f$, of the functional $\int f^2$ and goodness-of-fit test of the hypothesis $H_0:f=f_0$, where the alternative $H_1$ is expressed with respect to $\mathbb {L}_2$-norm (i.e. has the form $ψ_n^{-2}\|f-f_0\|_2^2\ge \mathcal{C}$). These procedures are adaptive with respect to both $s$ and $β$ and attain the rates which are known optimal for known values of $s$ and $β$. As a by-product, when the noise density is known and exponentially smooth our testing procedure is optimal adaptive for testing Sobolev-type densities. The estimating procedure of $s$ is illustrated on synthetic data.

math.ST↗

arXiv2007

Adaptive procedures in convolution models with known or partially known noise distribution

In a convolution model, we observe random variables whose distribution is the convolution of some unknown density f and some known or partially known noise density g. In this paper, we focus on statistical procedures, which are adaptive with respect to the smoothness parameter tau of unknown density f, and also (in some cases) to some unknown parameter of the noise density g. In a first part, we assume that g is known and polynomially smooth. We provide goodness-of-fit procedures for the test H_0:f=f_0, where the alternative H_1 is expressed with respect to L_2-norm. Our adaptive (w.r.t tau) procedure behaves differently according to whether f_0 is polynomially or exponentially smooth. A payment for adaptation is noted in both cases and for computing this, we provide a non-uniform Berry-Esseen type theorem for degenerate U-statistics. In the first case we prove that the payment for adaptation is optimal (thus unavoidable). In a second part, we study a wider framework: a semiparametric model, where g is exponentially smooth and stable, and its self-similarity index s is unknown. In order to ensure identifiability, we restrict our attention to polynomially smooth, Sobolev-type densities f. In this context, we provide a consistent estimation procedure for s. This estimator is then plugged-into three different procedures: estimation of the unknown density f, of the functional \int f^2 and test of the hypothesis H_0. These procedures are adaptive with respect to both s and tau and attain the rates which are known optimal for known values of s and tau. As a by-product, when the noise is known and exponentially smooth our testing procedure is adaptive for testing Sobolev-type densities.

math.ST↗

arXiv2005

Parameter estimation in pair hidden Markov models

This paper deals with parameter estimation in pair hidden Markov models (pair-HMMs). We first provide a rigorous formalism for these models and discuss possible definitions of likelihoods. The model being biologically motivated, some restrictions with respect to the full parameter space naturally occur. Existence of two different Information divergence rates is established and divergence property (namely positivity at values different from the true one) is shown under additional assumptions. This yields consistency for the parameter in parametrization schemes for which the divergence property holds. Simulations illustrate different cases which are not covered by our results.

math.ST↗