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Cemre Ariyurek

Publications and source records attributed to Cemre Ariyurek.

4 recordsLinked to original sources

Primitive Representation Learning for Unsupervised Dynamic Contrast Enhanced MRI Reconstruction

Reliable quantitative analysis of dynamic contrast-enhanced MRI requires high-quality spatiotemporal reconstructions at high undersampling rates. Scan-specific reconstructions using Gaussian and Gabor primitives have shown promising results without the need for large training datasets, but have not addressed the additional dimension of dynamic contrast. We propose a multi-dimensional, primitive based framework for dynamic contrast-enhanced MRI reconstruction that disentangles the underlying anatomy, the dynamic contrast enhancement, and residual motion into separate temporal basis functions, thereby enabling a geometrical interpretation of the representation. We show that this architecture achieves performance competitive with conventional reconstruction methods, both in reconstruction quality and in the accuracy of extracted aorta and kidney enhancement curves. The modular tier design extends naturally to additional dynamic factors and higher acceleration rates. Code available at https://github.com/compai-lab/2026-GaborDCE-spieker.

eess.IV

Vendor-Agnostic Joint Relaxometry and Myelin Water Fraction Mapping with B1 and Motion Correction

Obtaining consistent quantitative maps of myelin content and relaxation times across different sites and vendors is essential for advancing our understanding of brain development. Herein, we present a harmonized, vendor-agnostic magnetic resonance acquisition method designed for joint T1, T2, and myelin water fraction mapping, along with a method for rapid B1+ and B1- field estimation. We used our dictionary-based fitting and multi-compartment modeling for joint mapping of T1, T2 and myelin water fraction. Self-navigation-based retrospective motion correction was integrated with subspace reconstruction to track and correct rigid head motion during scanning, operating without the need for external hardware. Simulations, phantom and in vivo experiments confirmed the sensitivity and accuracy of the method, particularly for short T2 values corresponding to myelin, and demonstrated consistent performance across multiple scanner types. Coupled with the harmonized calibration scan, the proposed package offers a practical tool for multi-site, multi-vendor neuroimaging studies in both adult and pediatric populations.

physics.med-ph

An Optimized Binning and Probabilistic Slice Sharing Algorithm for Motion Correction in Abdominal DW-MRI

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a powerful, non-invasive tool for detecting and characterizing abdominal lesions to facilitate early diagnosis, but respiratory motion during a scan reduces image quality and accuracy of quantitative biomarkers. Respiratory binning, which groups image slices into motion phase bins based on a navigator signal, can help mitigate motion artifacts. However, in DW-MRI, the standard binning technique often generates volumes with missing slices along the superior-inferior axis. Thus, longer scans are required to obtain volumes without gaps. In this study, we proposed a new binning technique to minimize missing slices without increasing scan time. We first designed an algorithm using dynamic programming and prefix sum approaches to optimize the initial binning of MR images. Then, we developed a probabilistic refinement phase, selecting some slices to belong in two neighboring bins to further reduce missing slices. We tested our two-phase technique on free-breathing abdominal DW-MRI scans from eight subjects, including one with tumors. The proposed technique significantly reduced missing slices compared to standard binning (p<1.0*10-15), yielding an average reduction of 81.74+/-7.58%. Our technique also reduced motion artifacts, improving the conspicuity of malignant lesions. Apparent Diffusion Coefficient (ADC) maps generated from free-breathing scans corrected using the proposed technique had lower intra-subject variability compared to ADC maps from uncorrected free-breathing and shallow-breathing scans (p<0.001). Additionally, ADC maps from shallow-breathing scans were more consistent with corrected free-breathing maps rather than uncorrected free-breathing maps (p<0.01). The proposed technique corrects for motion while simultaneously reducing missing slices, allowing for shorter acquisition times compared to standard binning.

eess.IV

Learning the Regularization in DCE-MR Image Reconstruction for Functional Imaging of Kidneys

Kidney DCE-MRI aims at both qualitative assessment of kidney anatomy and quantitative assessment of kidney function by estimating the tracer kinetic (TK) model parameters. Accurate estimation of TK model parameters requires an accurate measurement of the arterial input function (AIF) with high temporal resolution. Accelerated imaging is used to achieve high temporal resolution, which yields under-sampling artifacts in the reconstructed images. Compressed sensing (CS) methods offer a variety of reconstruction options. Most commonly, sparsity of temporal differences is encouraged for regularization to reduce artifacts. Increasing regularization in CS methods removes the ambient artifacts but also over-smooths the signal temporally which reduces the parameter estimation accuracy. In this work, we propose a single image trained deep neural network to reduce MRI under-sampling artifacts without reducing the accuracy of functional imaging markers. Instead of regularizing with a penalty term in optimization, we promote regularization by generating images from a lower dimensional representation. In this manuscript we motivate and explain the lower dimensional input design. We compare our approach to CS reconstructions with multiple regularization weights. Proposed approach results in kidney biomarkers that are highly correlated with the ground truth markers estimated using the CS reconstruction which was optimized for functional analysis. At the same time, the proposed approach reduces the artifacts in the reconstructed images.

cs.LG