arXiv subjects

Changhui Li

Publications and source records attributed to Changhui Li.

13 recordsLinked to original sources

arXiv2026

Dual-Domain Self-Supervised Artifact Removal Framework for Photoacoustic Computed Tomography

Photoacoustic Computed Tomography (PACT) often faces severe challenges from reconstruction artifacts due to sparse detection conditions. In this work, based on the distinct differences in artifact patterns between back-projection-based and Fourier-based reconstruction algorithms, we propose a self-supervised artifact removal framework that employs a lightweight Siamese Neural Network and a composite loss function integrating cross-domain fidelity and uncertainty-weighted consistency, effectively decoupling dual-domain features and filtering artifacts. Comprehensive validations using simulations, phantoms, in vivo rat and human experimental data demonstrate that the proposed method can significantly suppress image artifacts. Furthermore, enabled by the acceleration of the spatial-domain and frequency-domain inverse operator, this end-to-end approach also achieves exceptional computational efficiency.

cs.CV↗

arXiv2026

PA-SFM: Tracker-free differentiable acoustic radiation for freehand 3D photoacoustic imaging

Three-dimensional (3D) handheld photoacoustic tomography typically relies on bulky and expensive external positioning sensors to correct motion artifacts, which severely limits its clinical flexibility and accessibility. To address this challenge, we present PA-SFM, a tracker-free framework that leverages exclusively single-modality photoacoustic data for both sensor pose recovery and high-fidelity 3D reconstruction via differentiable acoustic radiation modeling. Unlike traditional structure-from-motion (SFM) methods based on visual features, PA-SFM integrates the acoustic wave equation into a differentiable programming pipeline. By leveraging a high-performance, GPU-accelerated acoustic radiation kernel, the framework simultaneously optimizes the 3D photoacoustic source distribution and the sensor array pose via gradient descent. To ensure robust convergence in freehand scenarios, we introduce a coarse-to-fine optimization strategy that incorporates geometric consistency checks and rigid-body constraints to eliminate motion outliers. We validated the proposed method through both numerical simulations and in-vivo rat experiments. The results demonstrate that PA-SFM achieves sub-millimeter positioning accuracy and restores high-resolution 3D vascular structures comparable to ground-truth benchmarks, offering a low-cost, software-defined solution for clinical freehand photoacoustic imaging. The source code is publicly available at \href{https://github.com/JaegerCQ/PA-SFM}{https://github.com/JaegerCQ/PA-SFM}.

cs.CV↗

arXiv2026

GPAIR: Gaussian-Kernel-Based Ultrafast 3D Photoacoustic Iterative Reconstruction

Although the iterative reconstruction (IR) algorithm can substantially correct reconstruction artifacts in photoacoustic (PA) computed tomography (PACT), it suffers from long reconstruction times, especially for large-scale three-dimensional (3D) imaging in which IR takes hundreds of seconds to hours. The computing burden severely limits the practical applicability of IR algorithms. In this work, we proposed an ultrafast IR method for 3D PACT, called Gaussian-kernel-based Ultrafast 3D Photoacoustic Iterative Reconstruction (GPAIR), which achieves orders-of-magnitude acceleration in computing. GPAIR transforms traditional spatial grids with continuous isotropic Gaussian kernels. By deriving analytical closed-form expression for pressure waves and implementing powerful GPU-accelerated differentiable Triton operators, GPAIR demonstrates extraordinary ultrafast sub-second reconstruction speed for 3D targets containing 8.4 million voxels in animal experiments. This revolutionary ultrafast image reconstruction enables near-real-time large-scale 3D PA reconstruction, significantly advancing 3D PACT toward clinical applications.

cs.CV↗

arXiv2026

Analytical Expression for Spherically Symmetric Photoacoustic Sources: A Unified General Solution (Theoretical Analysis and Derivation)

Here we present a comprehensive derivation of the analytical expression for the spatiotemporal acoustic pressure generated by photoacoustic sources with spherically symmetric initial pressure distributions. Starting from the fundamental photoacoustic wave equation, we derive a unified analytical solution applicable to arbitrary spherically symmetric initial distributions. Specific expressions are provided for several common distributions including uniform spherical sources, Gaussian distributions, exponential distributions, and power-law distributions. Far-field approximations are also discussed. The derived expressions provide valuable tools for photoacoustic imaging system design and signal analysis. We provide codes for ultrafast forward simulation using the general analytical spherically symmetric model, the implementation is available in the GitHub repository: \href{https://github.com/JaegerCQ/SlingBAG_Ultra}.

physics.optics↗

arXiv2026

SlingBAG Pro: Accelerating point cloud-based iterative reconstruction for 3D photoacoustic imaging with arbitrary array geometries

High-quality three-dimensional (3D) photoacoustic imaging (PAI) is gaining increasing attention in clinical applications. To address the challenges of limited space and high costs, irregular geometric transducer arrays that conform to specific imaging regions are promising for achieving high-quality 3D PAI with fewer transducers. However, traditional iterative reconstruction algorithms struggle with irregular array configurations, suffering from high computational complexity, substantial memory requirements, and lengthy reconstruction times. In this work, we introduce SlingBAG Pro, an advanced reconstruction algorithm based on the point cloud iteration concept of the Sliding ball adaptive growth (SlingBAG) method, while extending its compatibility to arbitrary array geometries. SlingBAG Pro maintains high reconstruction quality, reduces the number of required transducers, and employs a hierarchical optimization strategy that combines zero-gradient filtering with progressively increased temporal sampling rates during iteration. This strategy rapidly removes redundant spatial point clouds, accelerates convergence, and significantly shortens overall reconstruction time. Compared to the original SlingBAG algorithm, SlingBAG Pro achieves up to a 2.2-fold speed improvement in point cloud-based 3D PA reconstruction under irregular array geometries. The proposed method is validated through both simulation and in vivo mouse experiments, and the source code is publicly available at https://github.com/JaegerCQ/SlingBAG_Pro.

cs.CV↗

arXiv2025

Multifunctional tapered fiber-based micro-waveguide for optical ultrasound microsensors

Various optical ultrasound microsensors have been developed with size ranging from tens to hundreds of micrometers. However, it becomes challenging to further minimize these sensors' size. In this work, we proposed a method that use a tapered fiber-based micro-waveguide (TFMW) attaching to the optical microsensor to bypass this challenge. The TFMW not only serves as the waveguide to transport ultrasound, but can also deliver light and actively excite ultrasound. In this study, we proposed the design and analyzed its performance using theoretical analysis and simulation.

physics.optics↗

arXiv2025

Developing an Open-Source Framework for Quantitative Simulation of Blood Flow and Tissue Motion for Ultrafast Doppler Ultrasound

Ultrafast power Doppler imaging (uPDI) has become a powerful tool for both research and clinical applications. However, existing simulation tools are insufficient for generating quantitatively accurate three-dimensional (3D) flow fields with tissue motion mimicking in vivo conditions. In this study, we present an open-source framework, named 3D-Fully Quantitative Flow (3D-FQFlow), to provide quantitative modeling of 3D vascular hemodynamics with physiologically realistic tissue motion for uPDI. The framework can perform quantitative modeling of both hemodynamics and tissue motion for either user-defined or clinical-derived vasculatures. Besides, it also integrates a GPU-accelerated image processing and reconstruction module. We demonstrate the performance of 3D-FQFlow using both synthetic vascular structures and clinical datasets. This framework could provide essential ground-truth simulation models to support the development, validation, and benchmarking of uPDI techniques. The source code is freely available online athttps://github.com/FortuneOU/3D-FQFlow.

eess.SP↗

arXiv2024

Zero-Shot Artifact2Artifact: Self-incentive artifact removal for photoacoustic imaging without any data

Photoacoustic imaging (PAI) uniquely combines optical contrast with the penetration depth of ultrasound, making it critical for clinical applications. However, the quality of 3D PAI is often degraded due to reconstruction artifacts caused by the sparse and angle-limited configuration of detector arrays. Existing iterative or deep learning-based methods are either time-consuming or require large training datasets, significantly limiting their practical application. Here, we propose Zero-Shot Artifact2Artifact (ZS-A2A), a zero-shot self-supervised artifact removal method based on a super-lightweight network, which leverages the fact that reconstruction artifacts are sensitive to irregularities caused by data loss. By introducing random perturbations to the acquired PA data, it spontaneously generates subset data, which in turn stimulates the network to learn the artifact patterns in the reconstruction results, thus enabling zero-shot artifact removal. This approach requires neither training data nor prior knowledge of the artifacts, and is capable of artifact removal for 3D PAI. For maximum amplitude projection (MAP) images or slice images in 3D PAI acquired with arbitrarily sparse or angle-limited detector arrays, ZS-A2A employs a self-incentive strategy to complete artifact removal and improves the Contrast-to-Noise Ratio (CNR). We validated ZS-A2A in both simulation study and $ in\ vivo $ animal experiments. Results demonstrate that ZS-A2A achieves state-of-the-art (SOTA) performance compared to existing zero-shot methods, and for the $ in\ vivo $ rat liver, ZS-A2A improves CNR from 17.48 to 43.46 in just 8 seconds. The project for ZS-A2A will be available in the following GitHub repository: https://github.com/JaegerCQ/ZS-A2A.

cs.CV↗

arXiv2024

4D SlingBAG: spatial-temporal coupled Gaussian ball for large-scale dynamic 3D photoacoustic iterative reconstruction

Large-scale dynamic three-dimensional (3D) photoacoustic imaging (PAI) is significantly important in clinical applications. In practical implementations, large-scale 3D real-time PAI systems typically utilize sparse two-dimensional (2D) sensor arrays with certain angular deficiencies, necessitating advanced iterative reconstruction (IR) algorithms to achieve quantitative PAI and reduce reconstruction artifacts. However, for existing IR algorithms, multi-frame 3D reconstruction leads to extremely high memory consumption and prolonged computation time, with limited consideration of the spatial-temporal continuity between data frames. Here, we propose a novel method, named the 4D sliding Gaussian ball adaptive growth (4D SlingBAG) algorithm, based on the current point cloud-based IR algorithm sliding Gaussian ball adaptive growth (SlingBAG), which has minimal memory consumption among IR methods. Our 4D SlingBAG method applies spatial-temporal coupled deformation functions to each Gaussian sphere in point cloud, thus explicitly learning the deformations features of the dynamic 3D PA scene. This allows for the efficient representation of various physiological processes (such as pulsation) or external pressures (e.g., blood perfusion experiments) contributing to changes in vessel morphology and blood flow during dynamic 3D PAI, enabling highly efficient IR for dynamic 3D PAI. Simulation experiments demonstrate that 4D SlingBAG achieves high-quality dynamic 3D PA reconstruction. Compared to performing reconstructions by using SlingBAG algorithm individually for each frame, our method significantly reduces computational time and keeps a extremely low memory consumption. The project for 4D SlingBAG can be found in the following GitHub repository: \href{https://github.com/JaegerCQ/4D-SlingBAG}{https://github.com/JaegerCQ/4D-SlingBAG}.

cs.CV↗

arXiv2024

Sliding Gaussian ball adaptive growth (SlingBAG): point cloud-based iterative algorithm for large-scale 3D photoacoustic imaging

Large-scale 3D photoacoustic (PA) imaging has become increasingly important for both clinical and pre-clinical applications. Limited by cost and system complexity, only systems with sparsely-distributed sensors can be widely implemented, which desires advanced reconstruction algorithms to reduce artifacts. However, high computing memory and time consumption of traditional iterative reconstruction (IR) algorithms is practically unacceptable for large-scale 3D PA imaging. Here, we propose a point cloud-based IR algorithm that reduces memory consumption by several orders, wherein the 3D PA scene is modeled as a series of Gaussian-distributed spherical sources stored in form of point cloud. During the IR process, not only are properties of each Gaussian source, including its peak intensity (initial pressure value), standard deviation (size) and mean (position) continuously optimized, but also each Gaussian source itself adaptively undergoes destroying, splitting, and duplication along the gradient direction. This method, named the sliding Gaussian ball adaptive growth (SlingBAG) algorithm, enables high-quality large-scale 3D PA reconstruction with fast iteration and extremely low memory usage. We validated SlingBAG algorithm in both simulation study and in vivo animal experiments. The source code and data for SlingBAG, along with supplementary materials and demonstration videos, are now available in the following GitHub repository: https://github.com/JaegerCQ/SlingBAG.

cs.CV↗

arXiv2022

High sensitivity air-coupled MHz frequency ultrasound detection using on-chip microcavities

Owing to their dual-resonance enhanced sensitivity, cavity optomechanical systems provide an ideal platform for ultrasound sensing. In this work, we realize high sensitivity air-coupled ultrasound sensing from kilohertz (kHz) to megahertz (MHz) frequency range based on whispering gallery mode microcavities. Using a 57 um-diameter microtoroid with high optical Q factor (~10^7) and mechanical Q factor (~700), we achieve sensitivities of 46 uPa Hz^{-1/2}-10 mPa Hz^{-1/2} in a frequency range of 0.25-3.2 MHz. Thermal-noise-limited sensitivity is realized around the mechanical resonance at 2.56 MHz, in a frequency range of 0.6 MHz. We also observe the second- and third-order mechanical sidebands, and quantitatively study the intensities of each mechanical sideband as a function of the mechanical displacement. Measuring the combination of signal to noise ratios at all sidebands has the potential to extend the dynamic range of ultrasound sensing. In addition, to improve the ultrasound sensitivity in the kHz frequency range, we use a microdisk with a diameter of 200 um, and achieve sensitivities of 1.83 uPa Hz^{-1/2}-10.4 mPa Hz^{-1/2} in 30 kHz-1.65 MHz range.

physics.optics↗

arXiv2019

Cherenkov Radiation Induced by Megavolt X-Ray Beams in the Second Near-Infrared Window

Although the Cherenkov light contains mostly short-wavelength components, it is beneficial in the aspect of imaging to visualize it in the second near-infrared (NIR-II) window. In this study, Cherenkov imaging was performed within the NIR-II range on megavolt X-ray beams delivered by a medical linear accelerator. A shielding system was used to reduce the noises of the NIR-II image, enabling high quality signal acquisition. It was demonstrated that the NIR-II Cherenkov imaging is potentially a tool for radiotherapy dosimetry, and correlates well with different parameters. The NIR-II Cherenkov imaging is less susceptible to scattering, while more susceptible to absorption, compared with the visible-near-infrared imaging. Finally, a mouse was used to demonstrate this technology on animals. These results indicate the potentials to apply NIR-II Cherenkov imaging in the practice of radiotherapy.

physics.med-ph↗

arXiv2001

Dirac Neutrino Masses in NCG

Several models in NCG with mild changes to the standard model(SM)are introduced to discuss the neutrino mass problem. We use two constraints, Poincar$\acute{e}$ duality and gauge anomaly free, to discuss the possibility of containing right-handed neutrinos in them. Our work shows that no model in this paper, with each generation containing a right-handed neutrino, can satisfy these two constraints in the same time. So, to consist with neutrino oscillation experiment results, maybe fundamental changes to the present version of NCG are usually needed to include Dirac massive neutrinos.

hep-th↗