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Changlong Li

Publications and source records attributed to Changlong Li.

4 recordsLinked to original sources

Bayesian Fully-Connected Tensor Network for Hyperspectral-Multispectral Image Fusion

Tensor decomposition is a powerful tool for data analysis and has been extensively employed in the field of hyperspectral-multispectral image fusion (HMF). Existing tensor decomposition-based fusion methods typically rely on disruptive data vectorization/reshaping or impose rigid constraints on the arrangement of factor tensors, hindering the preservation of spatial-spectral structures and the modeling of cross-dimensional correlations. Although recent advances utilizing the Fully-Connected Tensor Network (FCTN) decomposition have partially alleviated these limitations, the process of reorganizing data into higher-order tensors still disrupts the intrinsic spatial-spectral structure. Furthermore, these methods necessitate extensive manual parameter tuning and exhibit limited robustness against noise and spatial degradation. To alleviate these issues, we propose the Bayesian FCTN (BFCTN) method. Within this probabilistic framework, a hierarchical sparse prior that characterizing the sparsity of physical elements, establishes connections between the factor tensors. This framework explicitly models the intrinsic physical coupling among spatial structures, spectral signatures, and local scene homogeneity. For model learning, we develop a parameter estimation method based on Variational Bayesian inference (VB) and the Expectation-Maximization (EM) algorithm, which significantly reduces the need for manual parameter tuning. Extensive experiments demonstrate that BFCTN not only achieves state-of-the-art fusion accuracy and strong robustness but also exhibits practical applicability in complex real-world scenarios.

cs.CV

Identification of Repurposable Drugs and Adverse Drug Reactions for Various Courses of COVID-19 Based on Single-Cell RNA Sequencing Data

Coronavirus disease 2019 (COVID-19) has impacted almost every part of human life worldwide, posing a massive threat to human health. There is no specific drug for COVID-19, highlighting the urgent need for the development of effective therapeutics. To identify potentially repurposable drugs, we employed a systematic approach to mine candidates from U.S. FDA-approved drugs and preclinical small-molecule compounds by integrating the gene expression perturbation data for chemicals from the Library of Integrated Network-Based Cellular Signatures project with a publicly available single-cell RNA sequencing dataset from mild and severe COVID-19 patients. We identified 281 FDA-approved drugs that have the potential to be effective against SARS-CoV-2 infection, 16 of which are currently undergoing clinical trials to evaluate their efficacy against COVID-19. We experimentally tested the inhibitory effects of tyrphostin-AG-1478 and brefeldin-a on the replication of the single-stranded ribonucleic acid (ssRNA) virus influenza A virus. In conclusion, we have identified a list of repurposable anti-SARS-CoV-2 drugs using a systems biology approach.

q-bio.GN

Generative Reversible Data Hiding by Image to Image Translation via GANs

The traditional reversible data hiding technique is based on cover image modification which inevitably leaves some traces of rewriting that can be more easily analyzed and attacked by the warder. Inspired by the cover synthesis steganography based generative adversarial networks, in this paper, a novel generative reversible data hiding scheme (GRDH) by image translation is proposed. First, an image generator is used to obtain a realistic image, which is used as an input to the image-to-image translation model with CycleGAN. After image translation, a stego image with different semantic information will be obtained. The secret message and the original input image can be recovered separately by a well-trained message extractor and the inverse transform of the image translation. Experimental results have verified the effectiveness of the scheme.

eess.IV

DSA: Scalable Distributed Sequence Alignment System Using SIMD Instructions

Sequence alignment algorithms are a basic and critical component of many bioinformatics fields. With rapid development of sequencing technology, the fast growing reference database volumes and longer length of query sequence become new challenges for sequence alignment. However, the algorithm is prohibitively high in terms of time and space complexity. In this paper, we present DSA, a scalable distributed sequence alignment system that employs Spark to process sequences data in a horizontally scalable distributed environment, and leverages data parallel strategy based on Single Instruction Multiple Data (SIMD) instruction to parallelize the algorithm in each core of worker node. The experimental results demonstrate that 1) DSA has outstanding performance and achieves up to 201x speedup over SparkSW. 2) DSA has excellent scalability and achieves near linear speedup when increasing the number of nodes in cluster.

cs.DC