Changming Wang | Searcharxiv

arXiv2026

Distinct Radiobiological Responses to BNCT in SAS Oral Squamous Cell Carcinoma and MCF-7 Breast Cancer Cells

This work compared the radiobiological responses of SAS oral squamous cell carcinoma cells and MCF-7 breast cancer cells following accelerator-based boron neutron capture therapy (BNCT). Neutrons were generated by bombarding a lithium target with proton beams, followed by moderation to obtain sufficient thermal neutrons for BNCT irradiation. Boronophenylalanine (BPA) was used as the boron delivery agent. BNCT-induced biological responses were evaluated by gamma-H2AX immunofluorescence staining, cell-cycle analysis, apoptosis analysis, and clonogenic survival assays. BNCT induced marked gamma-H2AX foci formation in both cell lines, indicating DNA damage-associated responses after irradiation. The two cell lines further showed distinct post-irradiation outcomes. SAS cells exhibited stronger clonogenic suppression and prominent G2/M accumulation, whereas MCF-7 cells showed sustained G0/G1 accumulation and delayed apoptosis. These results suggest that BNCT sensitivity is determined by both boron accumulation and cell-line-specific biological characteristics. This work provides experimental evidence highlighting the importance of tumor-dependent cellular responses in understanding and optimizing BNCT efficacy.

physics.med-ph↗

arXiv2026

Predicting Only from Selected Evidence: A Tempered Product-of-Experts Bottleneck for Auditable EEG Diagnosis

Pretrained EEG backbones improve transfer performance, but downstream diagnosis heads remain hard to audit: predictions are made from unrestricted hidden states, whereas explanations are usually produced only after the decision. We introduce tPoE-EIB, an evidence-information bottleneck head for adapting EEG backbones under an evidence-only prediction constraint. tPoE-EIB selects temporal and channel evidence, maps the selected summaries to Gaussian experts over a shared latent variable, and fuses them with a tempered product-of-experts posterior. The classifier observes only this latent, so the decision path is explicit and rate-limited by the expected posterior KL. This gives a tractable supervised objective with an information-rate penalty, while the closed-form tempered posterior mitigates overconfident fusion from correlated evidence axes. We evaluate tPoE-EIB on pretrained EEG foundation-model backbones across six diagnosis settings: event-type classification, abnormality detection, seizure detection, cognitive-decline staging, depression screening, and cerebrovascular-disease classification. The evaluation spans public benchmarks and in-house clinical cohorts, binary screening and fine-grained staging, and sparse and dense montages. tPoE-EIB preserves competitive balanced accuracy and improves over representative post-hoc explanations on selection-faithfulness audits, including insertion-deletion and gate-causality tests. Its structured posterior further enables integration-faithfulness audits, including expert-drop, posterior-reliance, and expert-disagreement tests. Overall, these results suggest that evidence-only, rate-limited fusion is a practical route to auditable diagnosis on top of frozen EEG foundation backbones.

eess.SP↗