arXiv subjects

Charles B Delahunt

Publications and source records attributed to Charles B Delahunt.

3 recordsLinked to original sources

arXiv2023

How Good Are Synthetic Medical Images? An Empirical Study with Lung Ultrasound

Acquiring large quantities of data and annotations is known to be effective for developing high-performing deep learning models, but is difficult and expensive to do in the healthcare context. Adding synthetic training data using generative models offers a low-cost method to deal effectively with the data scarcity challenge, and can also address data imbalance and patient privacy issues. In this study, we propose a comprehensive framework that fits seamlessly into model development workflows for medical image analysis. We demonstrate, with datasets of varying size, (i) the benefits of generative models as a data augmentation method; (ii) how adversarial methods can protect patient privacy via data substitution; (iii) novel performance metrics for these use cases by testing models on real holdout data. We show that training with both synthetic and real data outperforms training with real data alone, and that models trained solely with synthetic data approach their real-only counterparts. Code is available at https://github.com/Global-Health-Labs/US-DCGAN.

eess.IV↗

arXiv2020

Built to Last: Functional and structural mechanisms in the moth olfactory network mitigate effects of neural injury

Most organisms suffer neuronal damage throughout their lives, which can impair performance of core behaviors. Their neural circuits need to maintain function despite injury, which in particular requires preserving key system outputs. In this work, we explore whether and how certain structural and functional neuronal network motifs act as injury mitigation mechanisms. Specifically, we examine how (i) Hebbian learning, (ii) high levels of noise, and (iii) parallel inhibitory and excitatory connections contribute to the robustness of the olfactory system in the Manduca sexta moth. We simulate injuries on a detailed computational model of the moth olfactory network calibrated to in vivo data. The injuries are modeled on focal axonal swellings, a ubiquitous form of axonal pathology observed in traumatic brain injuries and other brain disorders. Axonal swellings effectively compromise spike train propagation along the axon, reducing the effective neural firing rate delivered to downstream neurons. All three of the network motifs examined significantly mitigate the effects of injury on readout neurons, either by reducing injury's impact on readout neuron responses or by restoring these responses to pre-injury levels. These motifs may thus be partially explained by their value as adaptive mechanisms to minimize the functional effects of neural injury. More generally, robustness to injury is a vital design principle to consider when analyzing neural systems.

q-bio.NC↗

arXiv2020

Insect cyborgs: Bio-mimetic feature generators improve machine learning accuracy on limited data

Machine learning (ML) classifiers always benefit from more informative input features. We seek to auto-generate stronger feature sets in order to address the difficulty that ML methods often experience given limited training data. A wide range of biological neural nets (BNNs) excel at fast learning, implying that they are adept at extracting informative features. We can thus look to BNNs for tools to improve ML performance in this low-data regime. The insect olfactory network learns new odors very rapidly, by means of three key elements: A competitive inhibition layer; a high-dimensional sparse plastic layer; and Hebbian updates of synaptic weights. In this work, we deployed MothNet, a computational model of the insect olfactory network, as an automatic feature generator: Attached as a front-end pre-processor, its Readout Neurons provided new features, derived from the original features, for use by standard ML classifiers. We found that these "insect cyborgs", i.e. classifiers that are part-insect model and part-ML method, had significantly better performance than baseline ML methods alone on a vectorized MNIST dataset. The MothNet feature generator also substantially out-performed other feature generating methods such as PCA, PLS, and NNs, as well as pre-training to initialize NN weights. Cyborgs improved relative test set accuracy by an average of 6% to 33% depending on baseline ML accuracy, while relative reduction in test set error exceeded 50% for higher baseline accuracy ML models. These results indicate the potential value of BNN-inspired feature generators in the ML context.

cs.ET↗