arXiv subjects

Chengbo Zheng

Publications and source records attributed to Chengbo Zheng.

13 recordsLinked to original sources

arXiv2026

CellPrism: A Visual Analytics System for Exploring AI-Driven Virtual Cells in Drug Discovery

Gene perturbation analysis plays a critical role in drug discovery by enabling researchers to investigate how interventions on specific genes influence global gene expression patterns within cells. Recent advances in artificial intelligence-driven virtual cell models have made it possible to predict gene expression outcomes for a wide range of perturbation strategies in silico, substantially reducing reliance on costly and time-consuming biological experiments. However, effectively exploring and interpreting the high-dimensional perturbation spaces produced by these models remains challenging because of the combinatorial nature of perturbations and the complex cell-specific gene expression responses they generate. In this work, we present CellPrism, a visual analytics system designed to support the systematic exploration of gene perturbation strategies for drug discovery. Specifically, CellPrism integrates clustering-based overviews to summarize perturbation outcomes, a glyph-based representation to compactly encode gene expression patterns across cell types, and coordinated views that enable fine-grained comparison and interpretation of perturbation effects. We demonstrate the effectiveness of CellPrism through a real-world case study and expert interviews. This work highlights the value of visual analytics in bridging virtual cell modeling with expert-driven decision making in drug discovery.

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arXiv2025

Supporting Data-Frame Dynamics in AI-assisted Decision Making

High stakes decision-making often requires a continuous interplay between evolving evidence and shifting hypotheses, a dynamic that is not well supported by current AI decision support systems. In this paper, we introduce a mixed-initiative framework for AI assisted decision making that is grounded in the data-frame theory of sensemaking and the evaluative AI paradigm. Our approach enables both humans and AI to collaboratively construct, validate, and adapt hypotheses. We demonstrate our framework with an AI-assisted skin cancer diagnosis prototype that leverages a concept bottleneck model to facilitate interpretable interactions and dynamic updates to diagnostic hypotheses.

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arXiv2025

Towards Human-AI Deliberation: Design and Evaluation of LLM-Empowered Deliberative AI for AI-Assisted Decision-Making

In AI-assisted decision-making, humans often passively review AI's suggestion and decide whether to accept or reject it as a whole. In such a paradigm, humans are found to rarely trigger analytical thinking and face difficulties in communicating the nuances of conflicting opinions to the AI when disagreements occur. To tackle this challenge, we propose Human-AI Deliberation, a novel framework to promote human reflection and discussion on conflicting human-AI opinions in decision-making. Based on theories in human deliberation, this framework engages humans and AI in dimension-level opinion elicitation, deliberative discussion, and decision updates. To empower AI with deliberative capabilities, we designed Deliberative AI, which leverages large language models (LLMs) as a bridge between humans and domain-specific models to enable flexible conversational interactions and faithful information provision. An exploratory evaluation on a graduate admissions task shows that Deliberative AI outperforms conventional explainable AI (XAI) assistants in improving humans' appropriate reliance and task performance. Based on a mixed-methods analysis of participant behavior, perception, user experience, and open-ended feedback, we draw implications for future AI-assisted decision tool design.

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arXiv2024

Mentigo: An Intelligent Agent for Mentoring Students in the Creative Problem Solving Process

With the increasing integration of large lauguage models (LLMs) in education, there is growing interest in using AI agents to support student learning in creative tasks. This study presents an interactive Mentor Agent system named Mentigo, which is designed to assist middle school students in the creative problem solving (CPS) process. We created a comprehensive dataset of real classroom interactions between students and mentors, which include the structured CPS task management, diverse guidance techniques, personalized feedback mechanisms. Based on this dataset, we create agentic workflow for the Mentigo system. The system's effectiveness was evaluated through a comparative experiment with 12 students and reviewed by five expert teachers. The Mentigo system demonstrated significant improvements in student engagement and creative outcomes. The findings provide design implications for leveraging LLMs to support CPS and offer insights into the application of AI mentor agents in educational contexts.

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arXiv2024

WaitGPT: Monitoring and Steering Conversational LLM Agent in Data Analysis with On-the-Fly Code Visualization

Large language models (LLMs) support data analysis through conversational user interfaces, as exemplified in OpenAI's ChatGPT (formally known as Advanced Data Analysis or Code Interpreter). Essentially, LLMs produce code for accomplishing diverse analysis tasks. However, presenting raw code can obscure the logic and hinder user verification. To empower users with enhanced comprehension and augmented control over analysis conducted by LLMs, we propose a novel approach to transform LLM-generated code into an interactive visual representation. In the approach, users are provided with a clear, step-by-step visualization of the LLM-generated code in real time, allowing them to understand, verify, and modify individual data operations in the analysis. Our design decisions are informed by a formative study (N=8) probing into user practice and challenges. We further developed a prototype named WaitGPT and conducted a user study (N=12) to evaluate its usability and effectiveness. The findings from the user study reveal that WaitGPT facilitates monitoring and steering of data analysis performed by LLMs, enabling participants to enhance error detection and increase their overall confidence in the results.

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arXiv2024

DiscipLink: Unfolding Interdisciplinary Information Seeking Process via Human-AI Co-Exploration

Interdisciplinary studies often require researchers to explore literature in diverse branches of knowledge. Yet, navigating through the highly scattered knowledge from unfamiliar disciplines poses a significant challenge. In this paper, we introduce DiscipLink, a novel interactive system that facilitates collaboration between researchers and large language models (LLMs) in interdisciplinary information seeking (IIS). Based on users' topics of interest, DiscipLink initiates exploratory questions from the perspectives of possible relevant fields of study, and users can further tailor these questions. DiscipLink then supports users in searching and screening papers under selected questions by automatically expanding queries with disciplinary-specific terminologies, extracting themes from retrieved papers, and highlighting the connections between papers and questions. Our evaluation, comprising a within-subject comparative experiment and an open-ended exploratory study, reveals that DiscipLink can effectively support researchers in breaking down disciplinary boundaries and integrating scattered knowledge in diverse fields. The findings underscore the potential of LLM-powered tools in fostering information-seeking practices and bolstering interdisciplinary research.

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arXiv2024

Charting the Future of AI in Project-Based Learning: A Co-Design Exploration with Students

The increasing use of Artificial Intelligence (AI) by students in learning presents new challenges for assessing their learning outcomes in project-based learning (PBL). This paper introduces a co-design study to explore the potential of students' AI usage data as a novel material for PBL assessment. We conducted workshops with 18 college students, encouraging them to speculate an alternative world where they could freely employ AI in PBL while needing to report this process to assess their skills and contributions. Our workshops yielded various scenarios of students' use of AI in PBL and ways of analyzing these uses grounded by students' vision of education goal transformation. We also found students with different attitudes toward AI exhibited distinct preferences in how to analyze and understand the use of AI. Based on these findings, we discuss future research opportunities on student-AI interactions and understanding AI-enhanced learning.

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arXiv2023

Competent but Rigid: Identifying the Gap in Empowering AI to Participate Equally in Group Decision-Making

Existing research on human-AI collaborative decision-making focuses mainly on the interaction between AI and individual decision-makers. There is a limited understanding of how AI may perform in group decision-making. This paper presents a wizard-of-oz study in which two participants and an AI form a committee to rank three English essays. One novelty of our study is that we adopt a speculative design by endowing AI equal power to humans in group decision-making.We enable the AI to discuss and vote equally with other human members. We find that although the voice of AI is considered valuable, AI still plays a secondary role in the group because it cannot fully follow the dynamics of the discussion and make progressive contributions. Moreover, the divergent opinions of our participants regarding an "equal AI" shed light on the possible future of human-AI relations.

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arXiv2023

A Multi-Layout Design for Immersive Visualization of Network Data

Visualization plays a vital role in making sense of complex network data. Recent studies have shown the potential of using extended reality (XR) for the immersive exploration of networks. The additional depth cues offered by XR help users perform better in certain tasks when compared to using traditional desktop setups. However, prior works on immersive network visualization rely on mostly static graph layouts to present the data to the user. This poses a problem since there is no optimal layout for all possible tasks. The choice of layout heavily depends on the type of network and the task at hand. We introduce a multi-layout approach that allows users to effectively explore hierarchical network data in immersive space. The resulting system leverages different layout techniques and interactions to efficiently use the available space in VR and provide an optimal view of the data depending on the task and the level of detail required to solve it. To evaluate our approach, we have conducted a user study comparing it against the state of the art for immersive network visualization. Participants performed tasks at varying spatial scopes. The results show that our approach outperforms the baseline in spatially focused scenarios as well as when the whole network needs to be considered.

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arXiv2023

Telling Stories from Computational Notebooks: AI-Assisted Presentation Slides Creation for Presenting Data Science Work

Creating presentation slides is a critical but time-consuming task for data scientists. While researchers have proposed many AI techniques to lift data scientists' burden on data preparation and model selection, few have targeted the presentation creation task. Based on the needs identified from a formative study, this paper presents NB2Slides, an AI system that facilitates users to compose presentations of their data science work. NB2Slides uses deep learning methods as well as example-based prompts to generate slides from computational notebooks, and take users' input (e.g., audience background) to structure the slides. NB2Slides also provides an interactive visualization that links the slides with the notebook to help users further edit the slides. A follow-up user evaluation with 12 data scientists shows that participants believed NB2Slides can improve efficiency and reduces the complexity of creating slides. Yet, participants questioned the future of full automation and suggested a human-AI collaboration paradigm.

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arXiv2023

Who Should I Trust: AI or Myself? Leveraging Human and AI Correctness Likelihood to Promote Appropriate Trust in AI-Assisted Decision-Making

In AI-assisted decision-making, it is critical for human decision-makers to know when to trust AI and when to trust themselves. However, prior studies calibrated human trust only based on AI confidence indicating AI's correctness likelihood (CL) but ignored humans' CL, hindering optimal team decision-making. To mitigate this gap, we proposed to promote humans' appropriate trust based on the CL of both sides at a task-instance level. We first modeled humans' CL by approximating their decision-making models and computing their potential performance in similar instances. We demonstrated the feasibility and effectiveness of our model via two preliminary studies. Then, we proposed three CL exploitation strategies to calibrate users' trust explicitly/implicitly in the AI-assisted decision-making process. Results from a between-subjects experiment (N=293) showed that our CL exploitation strategies promoted more appropriate human trust in AI, compared with only using AI confidence. We further provided practical implications for more human-compatible AI-assisted decision-making.

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arXiv2022

Evaluating the Effect of Enhanced Text-Visualization Integration on Combating Misinformation in Data Story

Misinformation has disruptive effects on our lives. Many researchers have looked into means to identify and combat misinformation in text or data visualization. However, there is still a lack of understanding of how misinformation can be introduced when text and visualization are combined to tell data stories, not to mention how to improve the lay public's awareness of possible misperceptions about facts in narrative visualization. In this paper, we first analyze where misinformation could possibly be injected into the production-consumption process of data stories through a literature survey. Then, as a first step towards combating misinformation in data stories, we explore possible defensive design methods to enhance the reader's awareness of information misalignment when data facts are scripted and visualized. More specifically, we conduct a between-subjects crowdsourcing study to investigate the impact of two design methods enhancing text-visualization integration, i.e., explanatory annotation and interactive linking, on users' awareness of misinformation in data stories. The study results show that although most participants still can not find misinformation, the two design methods can significantly lower the perceived credibility of the text or visualizations. Our work informs the possibility of fighting an infodemic through defensive design methods.

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arXiv2020

Towards Better Bus Networks: A Visual Analytics Approach

Bus routes are typically updated every 3-5 years to meet constantly changing travel demands. However, identifying deficient bus routes and finding their optimal replacements remain challenging due to the difficulties in analyzing a complex bus network and the large solution space comprising alternative routes. Most of the automated approaches cannot produce satisfactory results in real-world settings without laborious inspection and evaluation of the candidates. The limitations observed in these approaches motivate us to collaborate with domain experts and propose a visual analytics solution for the performance analysis and incremental planning of bus routes based on an existing bus network. Developing such a solution involves three major challenges, namely, a) the in-depth analysis of complex bus route networks, b) the interactive generation of improved route candidates, and c) the effective evaluation of alternative bus routes. For challenge a, we employ an overview-to-detail approach by dividing the analysis of a complex bus network into three levels to facilitate the efficient identification of deficient routes. For challenge b, we improve a route generation model and interpret the performance of the generation with tailored visualizations. For challenge c, we incorporate a conflict resolution strategy in the progressive decision-making process to assist users in evaluating the alternative routes and finding the most optimal one. The proposed system is evaluated with two usage scenarios based on real-world data and received positive feedback from the experts.

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