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Chenyi Liao

Publications and source records attributed to Chenyi Liao.

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Understanding Degradation with Vision Language Model

Understanding visual degradations is a critical yet challenging problem in computer vision. While recent Vision-Language Models (VLMs) excel at qualitative description, they often fall short in understanding the parametric physics underlying image degradations. In this work, we redefine degradation understanding as a hierarchical structured prediction task, necessitating the concurrent estimation of degradation types, parameter keys, and their continuous physical values. Although these sub-tasks operate in disparate spaces, we prove that they can be unified under one autoregressive next-token prediction paradigm, whose error is bounded by the value-space quantization grid. Building on this insight, we introduce DU-VLM, a multimodal chain-of-thought model trained with supervised fine-tuning and reinforcement learning using structured rewards. Furthermore, we show that DU-VLM can serve as a zero-shot controller for pre-trained diffusion models, enabling high-fidelity image restoration without fine-tuning the generative backbone. We also introduce \textbf{DU-110k}, a large-scale dataset comprising 110,000 clean-degraded pairs with grounded physical annotations. Extensive experiments demonstrate that our approach significantly outperforms generalist baselines in both accuracy and robustness, exhibiting generalization to unseen distributions.

cs.CV

On the Aggregation State of Synergistic Antimicrobial Peptides

By integrating various simulation and experimental techniques, we discovered that antimicrobial peptides (AMPs) may achieve synergy at an optimal concentration and ratio, which can be caused by aggregation of the synergistic peptides. On multiple time and length scales, our studies obtain novel evidence of how peptide co-aggregation in solution can affect disruption of membranes by synergistic AMPs. Our findings provide crucial details about the complex molecular origins of AMP synergy, which will help guide the future development of synergistic AMPs as well as applications of anti-infective peptide cocktail therapies.

physics.bio-ph