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Chiara Cardelli

Publications and source records attributed to Chiara Cardelli.

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Demolishing prejudices to get to the foundations: a criterion of demarcation for fundamentality

In this paper, we reject commonly accepted views on fundamentality in science, either based on bottom-up construction or top-down reduction to isolate the alleged fundamental entities. We do not introduce any new scientific methodology, but rather describe the current scientific methodology and show how it entails an inherent search for foundations of science. This is achieved by phrasing (minimal sets of) metaphysical assumptions into falsifiable statements and define as fundamental those that survive empirical tests. The ones that are falsified are rejected, and the corresponding philosophical concept is demolished as a prejudice. Furthermore, we show the application of this criterion in concrete examples of the search for fundamentality in quantum physics and biophysics.

physics.hist-ph

Conformity in virtual environments: a hybrid neurophysiological and psychosocial approach

The main aim of our study was to analyse the effects of a virtual environment on social conformity, with particular attention to the effects of different types of task and psychological variables on social influence, on one side, and to the neural correlates related to conformity, measured by means of an Emotiv EPOC device on the other. For our purpose, we replicated the famous Asch's visual task and created two new tasks of increasing ambiguity, assessed through the calculation of the item's entropy. We also administered five scales in order to assess different psychological traits. From the experiment, conducted on 181 university students, emerged that conformity grows according to the ambiguity of the task, but normative influence is significantly weaker in virtual environments, if compared to face-to-face experiments. The analysed psycho-logical traits, however, result not to be relatable to conformity, and they only affect the subjects' response times. From the ERP (Event-related potentials) analysis, we detected N200 and P300 components comparing the plots of conformist and non-conformist subjects, alongside with the detection of their Late Positive Potential, Readiness Potential, and Error-Related Negativity, which appear consistently different for the two typologies.

cs.HC

Universal criterion for designability of heteropolymers

Proteins are an example of heteropolymers able to self-assemble in specific target structures. The self-assembly of designed artificial heteropolymers is still, to the best of our knowledge, not possible with control over the single chain self-assembling properties comparable to what natural proteins can achieve. What artificial heteropolymers lacks compared to bio-heteropolymers that grants the latter such a versatility? Is the geometry of the protein skeleton the only a particular choice to be designable? Here we introduce a general criteria to discriminate which polymer backbones can be designed to adopt a predetermined structure. With our approach we can explore different polymer backbones and different amino acids alphabets. By comparing the radial distribution functions of designable and not-designable scenarios we identify as designability criteria the presence of a particular peak in the radial distribution function that dominates over the random packing of the heteropolymer. We show that the peak is a universal feature of all designable heteropolymers, as it is dominating also the radial distribution function of natural proteins. Our finding can help in understanding the key features that make proteins a highly designable system. The criteria that we present can be applied to engineer new types of self-assembling modular polymers that will open new applications for polymer based material science.

cond-mat.soft