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Chiara Seghieri

Publications and source records attributed to Chiara Seghieri.

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The Broken Shield of European Palliative Care: Evidence from Synthetic Counterfactuals on Financial Toxicity and Informal Care

The transition of end-of-life care to palliative care (PC) sparks intense debate: does it provide economic relief or shift unremunerated labor costs onto families? Evaluating this is hindered by causal inference challenges and skewed healthcare costs. To overcome these limitations, we introduce a Synthetic Data Generation framework. Using pan-European SHARE data (2016-2021), we deploy Tabular Denoising Diffusion Probabilistic Models within a Two-Learner architecture to synthesize high-fidelity digital twins. By including the 2020-2021 lockdowns, we leverage the COVID-19 pandemic to isolate structural inequalities from transient market shocks. Our findings challenge the strict cost-shifting hypothesis: on average, PC acts as a "double shield", truncating out-of-pocket expenditures (liquid toxicity) and informal caregiving shadow values (time poverty). However, quantile treatment models expose a "broken shield" for vulnerable households and severe tail events. Non-cancer trajectories drive massive structural penalties that escalate at the distribution's tail, mechanically compounded by physical dependency. Socio-demographics heavily modulate this exposure: lacking a spousal net inflates the burden, rigid gender dynamics trigger labor market ejection, and financial distress acts as a profound multiplier. Institutionally, high-wage Nordic regimes paradoxically impose opportunity costs, while severe penalties in underfunded Eastern systems-mediated by financial distress-drive families toward resource exhaustion. We conclude that while PC is an ethical imperative, its expansion must be decoupled from the oncological paradigm and matched with state-funded long-term care to protect against clinical decline and financial shocks.

stat.AP

Synthesizing the Counterfactual: A CTGAN-Augmented Causal Evaluation of Palliative Care on Spousal Depression

Spousal bereavement severely deteriorates mental health. While palliative care benefits dying patients, its "stress-buffering" effect on survivors' depression remains empirically elusive due to acute small-$N$ constraints in longitudinal dyadic data. This study evaluates the causal impact of palliative care on bereaved spouses while introducing Synthetic Data Generation (SDG) to resolve sample attrition in quasi-experimental designs. Using SHARE panel data, we augment the sparse treated cohort via a Conditional Tabular GAN, anchoring synthetic trajectories to empirical baseline constraints to preserve causal pathways. A Matched Difference-in-Differences estimator applied to the high-fidelity augmented dataset evaluates the treatment effect. Results reveal a non-linear psychological response. Palliative care initially exacerbates acute depressive symptoms at the time of loss ($\beta_0 = 0.218,\ p < 0.05$), reflecting the intense emotional confrontation of the intervention. However, a sustained stress-buffering effect emerges in subsequent periods ($\beta_2 = -0.763,\ p < 0.01$), indicating an accelerated long-term recovery compared to standard care. Estimates are highly robust to unobserved confounding (Oster's $\delta > 1$). Substantively, we advocate for reconceptualizing end-of-life care as a dyadic public health intervention. Methodologically, we establish SDG as a robust analytical tool capable of powering fragile quasi-experiments in longitudinal social surveys.

stat.AP