arXiv subjects

Chottiwatt Jittprasong

Publications and source records attributed to Chottiwatt Jittprasong.

3 recordsLinked to original sources

arXiv2022

Artificial Intelligence and Medicine: A literature review

In practically every industry today, artificial intelligence is one of the most effective ways for machines to assist humans. Since its inception, a large number of researchers throughout the globe have been pioneering the application of artificial intelligence in medicine. Although artificial intelligence may seem to be a 21st-century concept, Alan Turing pioneered the first foundation concept in the 1940s. Artificial intelligence in medicine has a huge variety of applications that researchers are continually exploring. The tremendous increase in computer and human resources has hastened progress in the 21st century, and it will continue to do so for many years to come. This review of the literature will highlight the emerging field of artificial intelligence in medicine and its current level of development.

q-bio.QM↗

arXiv2022

Mesenchymal stem cells as carrier cells to enable effective intratumoral delivery of oncolytic virus for oncolytic virotherapy: a systematic review

Oncolytic viruses, which may be naturally occurring or genetically engineered, are a type of virus that infects and destroy cancer cells preferentially. Owing to their selectivity, they outperform conventional chemotherapy and radiotherapy, which both have a tendency to impact non-target cells and cause unwanted adverse side effects. Oncolytic virotherapy is a type of cancer treatment in which oncolytic viruses are deliberately introduced into patients affected with cancers in order for them to infect and destroy cancer cells locally or systemically, in a manner analogous to chemotherapy but with a greater degree of selectivity. Multiple studies indicate that oncolytic virotherapy is effective in vitro but in vivo findings remain ambiguous due to the approach's primary limitation: inefficient therapeutic agent delivery to its target, which is heavily influenced by the immune system. Here, we propose overcoming this limitation by exploiting a recent discovery in cancer research: a carrier cell. By exploiting their tumor-promoting activities, mesenchymal stem cells may be employed for cancer therapy by serving as a carrier for the oncolytic viruses toward their target. This approach directly addresses the limitation of conventional oncolytic virotherapy, where oncolytic viruses are often poorly delivered after systemic administration.

q-bio.CB↗

arXiv2022

A feasibility study proposal of the predictive model to enable the prediction of population susceptibility to COVID-19 by analysis of vaccine utilization for advising deployment of a booster dose

With the present highly infectious dominant SARS-CoV-2 strain of B1.1.529 or Omicron spreading around the globe, there is concern that the COVID-19 pandemic will not end soon and that it will be a race against time until a more contagious and virulent variant emerges. One of the most promising approaches for preventing virus propagation is to maintain continuous high vaccination efficacy among the population, thereby strengthening the population protective effect and preventing the majority of infection in the vaccinated population, as is known to occur with the Omicron variant frequently. Countries must structure vaccination programs in accordance with their populations' susceptibility to infection, optimizing vaccination efforts by delivering vaccines progressively enough to protect the majority of the population. We present a feasibility study proposal for maintaining optimal continuous vaccination by assessing the susceptible population, the decline of vaccine efficacy in the population, and advising booster dosage deployment to maintain the population's protective efficacy through the use of a predictive model. Numerous studies have been conducted in the direction of analyzing vaccine utilization; however, very little study has been conducted to substantiate the optimal deployment of booster dosage vaccination with the help of a predictive model based on machine learning algorithms.

q-bio.PE↗