Making Models That Matter: How to Build Trustworthy and Useful Systems Biology Models
Computational models supporting mechanistic understanding of (complex) biological systems, systems behaviour prediction, and experimental design are becoming more and more embedded in research on complex biological systems. Reuse and refinement of models, rather than continuous reinvention, is becoming increasingly important as models' demands on computational infrastructure increase. However published models - despite the variety of efforts taken so far - are frequently difficult to reproduce or reuse, substantially limiting their scientific value. Here we address the requirements for model reusability in the light of the field-specific CURE framework (Credible, Understandable, Reproducible, Extensible) and the more general FAIR principles (Findable, Accessible, Interoperable, Reusable). Considering published guidance we identify broad agreement on requirements for findability, accessibility, and interoperability, but continued lack of clarity and consensus around reusability. Focusing on the scientific quality and usability of computational models we discuss six key practices underpinning model sharing and re-use. Mapping the FAIR and CURE principles onto the model lifecycle we propose ten recommendations for building and sharing systems biology models that are both FAIR- and CURE-compliant.