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Chris Salahub

Publications and source records attributed to Chris Salahub.

4 recordsLinked to original sources

Recursive random binning to detect and display pairwise dependence

Random binnings generated via recursive binary splits are introduced as a way to detect, measure the strength of, and to display the pattern of association between any two variates, whether one or both are continuous or categorical. This provides a single approach to ordering large numbers of variate pairs by their measure of dependence and then to examine any pattern of dependence via a common display, the departure display (colouring bins by a standardized Pearson residual). Continuous variates are first ranked and their rank pairs binned. The Pearson's goodness of fit statistic is applicable but the classic $χ^2$ approximation to its null distribution is not. Theoretical and empirical investigations motivate several approximations, including a simple $χ^2$ approximation with real-valued, yet intuitive, degrees of freedom. Alternatively, applying an inverse probability transform from the ranks before binning returns a simple Pearson statistic with the classic degrees of freedom. Recursive random binning with different approximations is compared to recent grid-based methods on a variety of non-null dependence patterns; the method with any of these approximations is found to be well-calibrated and relatively powerful against common test alternatives. Method and displays are illustrated by applying the screening methodology to a publicly available data set having several continuous and categorical measurements of each of 6,497 Portuguese wines. The software is publicly available as the R package AssocBin.

stat.ME

Optimal Structured Matrix Approximation for Robustness to Incomplete Biosequence Data

We propose a general method for optimally approximating an arbitrary matrix $\mathbf{M}$ by a structured matrix $\mathbf{T}$ (circulant, Toeplitz/Hankel, etc.) and examine its use for estimating the spectra of genomic linkage disequilibrium matrices. This application is prototypical of a variety of genomic and proteomic problems that demand robustness to incomplete biosequence information. We perform a simulation study and corroborative test of our method using real genomic data from the Mouse Genome Database. The results confirm the predicted utility of the method and provide strong evidence of its potential value to a wide range of bioinformatics applications. Our optimal general matrix approximation method is expected to be of independent interest to an even broader range of applications in applied mathematics and engineering.

stat.AP

Balancing central and marginal rejection when combining independent significance tests

A common approach to evaluating the significance of a collection of $p$-values combines them with a pooling function, in particular when the original data are not available. These pooled $p$-values convert a sample of $p$-values into a single number which behaves like a univariate $p$-value. To clarify discussion of these functions, a telescoping series of alternative hypotheses are introduced that communicate the strength and prevalence of non-null evidence in the $p$-values before general pooling formulae are discussed. A pattern noticed in the UMP pooled $p$-value for a particular alternative motivates the definition and discussion of central and marginal rejection levels at $α$. It is proven that central rejection is always greater than or equal to marginal rejection, motivating a quotient to measure the balance between the two for pooled $p$-values. A combining function based on the $χ^2_κ$ quantile transformation is proposed to control this quotient and shown to be robust to mis-specified parameters relative to the UMP. Different powers for different parameter settings motivate a map of plausible alternatives based on where this pooled $p$-value is minimized.

stat.ME

Approximating real symmetric Toeplitz matrices using the nearest circulant

The nearest circulant approximation of a real Toeplitz matrix in the Frobenius norm is derived. This matrix is symmetric. It is proven that symmetric circulant matrices are the only real circulant matrices with all real eigenvalues. The Frobenius norm of the difference between this approximation and the Toeplitz matrix for the case of a Toeplitz matrix displaying exponential decay is evaluated using an expression of $\sum_{n = 1}^N n^k p^n$ in terms of the first $k$ geometric moments. Compared to a classic approximation the nearest circulant displays dramatically better behaviour in any finite cases, though both share the same leading term for large $M$.

math.RA