arXiv subjects

Christine Devalland

Publications and source records attributed to Christine Devalland.

3 recordsLinked to original sources

arXiv2023

A new methodology to predict the oncotype scores based on clinico-pathological data with similar tumor profiles

Introduction: The Oncotype DX (ODX) test is a commercially available molecular test for breast cancer assay that provides prognostic and predictive breast cancer recurrence information for hormone positive, HER2-negative patients. The aim of this study is to propose a novel methodology to assist physicians in their decision-making. Methods: A retrospective study between 2012 and 2020 with 333 cases that underwent an ODX assay from three hospitals in Bourgogne Franche-Comt{é} was conducted. Clinical and pathological reports were used to collect the data. A methodology based on distributional random forest was developed using 9 clinico-pathological characteristics. This methodology can be used particularly to identify the patients of the training cohort that share similarities with the new patient and to predict an estimate of the distribution of the ODX score. Results: The mean age of participants id 56.9 years old. We have correctly classified 92% of patients in low risk and 40.2% of patients in high risk. The overall accuracy is 79.3%. The proportion of low risk correct predicted value (PPV) is 82%. The percentage of high risk correct predicted value (NPV) is approximately 62.3%. The F1-score and the Area Under Curve (AUC) are of 0.87 and 0.759, respectively. Conclusion: The proposed methodology makes it possible to predict the distribution of the ODX score for a patient and provides an explanation of the predicted score. The use of the methodology with the pathologist's expertise on the different histological and immunohistochemical characteristics has a clinical impact to help oncologist in decision-making regarding breast cancer therapy.

stat.AP↗

arXiv2022

A deep learning pipeline for breast cancer ki-67 proliferation index scoring

The Ki-67 proliferation index is an essential biomarker that helps pathologists to diagnose and select appropriate treatments. However, automatic evaluation of Ki-67 is difficult due to nuclei overlapping and complex variations in their properties. This paper proposes an integrated pipeline for accurate automatic counting of Ki-67, where the impact of nuclei separation techniques is highlighted. First, semantic segmentation is performed by combining the Squeez and Excitation Resnet and Unet algorithms to extract nuclei from the background. The extracted nuclei are then divided into overlapped and non-overlapped regions based on eight geometric and statistical features. A marker-based Watershed algorithm is subsequently proposed and applied only to the overlapped regions to separate nuclei. Finally, deep features are extracted from each nucleus patch using Resnet18 and classified into positive or negative by a random forest classifier. The proposed pipeline's performance is validated on a dataset from the Department of Pathology at Hôpital Nord Franche-Comté hospital.

eess.IV↗

arXiv2020

Spitzoid Lesions Diagnosis based on GA feature selection and Random Forest

Spitzoid lesions broadly categorized into Spitz Nevus (SN), Atypical Spitz Tumors (AST), and Spitz Melanomas (SM). The accurate diagnosis of these lesions is one of the most challenges for dermapathologists; this is due to the high similarities between them. Data mining techniques are successfully applied to situations like these where complexity exists. This study aims to develop an artificial intelligence model to support the diagnosis of Spitzoid lesions. A private spitzoid lesions dataset have been used to evaluate the system proposed in this study. The proposed system has three stages. In the first stage, SMOTE method applied to solve the imbalance data problem, in the second stage, in order to eliminate irrelevant features; genetic algorithm is used to select significant features. This later reduces the computational complexity and speed up the data mining process. In the third stage, Random forest classifier is employed to make a decision for two different categories of lesions (Spitz nevus or Atypical Spitz Tumors). The performance of our proposed scheme is evaluated using accuracy, sensitivity, specificity, G-mean, F- measure, ROC and AUC. Results obtained with our SMOTE-GA-RF model with GA-based 16 features show a great performance with accuracy 0.97, F-measure 0.98, AUC 0.98, and G-mean 0.97.Results obtained in this study have potential to open new opportunities in diagnosis of spitzoid lesions.

eess.IV↗