arXiv subjects

Christophe Pere

Publications and source records attributed to Christophe Pere.

12 recordsLinked to original sources

arXiv2026

Exploring the Effects of Entanglement on Quantum Machine Learning of Pathogen Epitope-Receptor Binding

Parameterized quantum circuits (PQCs) provide a flexible substrate for hybrid quantum machine learning (QML), but their practical value on Noisy Intermediate-Scale Quantum (NISQ) devices remains an empirical question, especially because training depth and scale can introduce optimization challenges such as barren plateaus. Here we study how the number and topology of two-qubit entangling gates in the feature-map stage influence a fixed hybrid QNN workflow for classifying strong versus weak epitope-receptor binding in Porcine Reproductive and Respiratory Syndrome (PRRS) vaccine design. The dataset consists of docking-derived binding affinities for N=80 9-mer epitopes, labeled as Strong or Weak binding, and partitioned into training, validation, and test subsets using a 40:30:30 split. We compare a classical CNN benchmark with a hybrid Embedding-QNN architecture under four feature-map configurations: a non-entangling Z feature map, an all-to-all high-entanglement ZZ feature map, and two interleaved nearest-neighbour entanglement patterns of low and high depth. Among the configurations tested, the high-entanglement ZZ feature map is seen to provide the strongest evidence of reduced training-set overfit, with a lower training area under the accuracy curve (AUAC) and the highest test/training AUAC ratio, while preserving competitive test-set accuracy. These results do not establish a general QML advantage, but they suggest that feature-map entanglement topology is a meaningful design variable for sparse biological screening tasks and warrants further evaluation with additional metrics, larger datasets, and noise-aware or hardware-based experiments.

quant-ph↗

arXiv2026

Breaking concentration barriers for quantum extreme learning on digital quantum processors

Reservoir computing leverages rich, non-linear dynamics to process temporal data. Quantum variants promise enhanced expressivity from high-dimensional Hilbert spaces, yet their practical applicability is hindered by hardware noise and concentration effects that can erase input-output distinguishability at large system sizes. In this work, we present and experimentally demonstrate a Quantum Extreme Learning Machine (QELM) tailored to state-of-the-art superconducting platforms, employing up to 124 qubits and circuits with more than 5,000 two-qubit gates on IBM Quantum computers. We introduce a practical multi-objective hyperparameter tuning strategy that jointly monitors observable variability, capacity, and task performance to identify noise-robust operating points. In addition, we develop a local eigentask analysis that enables computationally efficient feature selection and effective information retrieval. We report evidence of a regime of optimality that is identifiable at small scales and transferable across tasks and larger systems, and we achieve performances competitive with leading classical baselines on representative benchmarks for time-series forecasting and satellite image classification. Together, our results establish a viable and robust framework for large-scale, pre-fault-tolerant quantum machine learning and provide a foundation for extending reservoir-based methods to more expressive architectures and real-world scenarios.

quant-ph↗

arXiv2026

Robust GHZ State Preparation via Majority-Voted Boundary Measurements

Preparing high-fidelity Greenberger-Horne-Zeilinger (GHZ) states on noisy quantum hardware remains challenging due to cumulative gate errors and decoherence. We introduce Group-Majority-Voting (Group-MV), a dynamic-circuit protocol that partitions arbitrary coupling graphs, prepares local GHZ states in parallel, and fuses them via majority-voted mid-circuit measurements. The majority vote over redundant boundary links mitigates measurement errors that would otherwise propagate through classical feedforward. We evaluate Group-MV on simulated Heavy-hex and Grid topologies for 30 through 60 qubits under a realistic noise regime. Group-MV generalizes to arbitrary GHZ sizes on arbitrary coupling topologies, achieving 2.4x higher fidelity than the Line Dynamic method while tracking the unitary baseline within 3%.

quant-ph↗

arXiv2026

Generating High-quality Privacy-preserving Synthetic Data

Synthetic tabular data enables sharing and analysis of sensitive records, but its practical deployment requires balancing distributional fidelity, downstream utility, and privacy protection. We study a simple, model agnostic post processing framework that can be applied on top of any synthetic data generator to improve this trade off. First, a mode patching step repairs categories that are missing or severely underrepresented in the synthetic data, while largely preserving learned dependencies. Second, a k nearest neighbor filter replaces synthetic records that lie too close to real data points, enforcing a minimum distance between real and synthetic samples. We instantiate this framework for two neural generative models for tabular data, a feed forward generator and a variational autoencoder, and evaluate it on three public datasets covering credit card transactions, cardiovascular health, and census based income. We assess marginal and joint distributional similarity, the performance of models trained on synthetic data and evaluated on real data, and several empirical privacy indicators, including nearest neighbor distances and attribute inference attacks. With moderate thresholds between 0.2 and 0.35, the post processing reduces divergence between real and synthetic categorical distributions by up to 36 percent and improves a combined measure of pairwise dependence preservation by 10 to 14 percent, while keeping downstream predictive performance within about 1 percent of the unprocessed baseline. At the same time, distance based privacy indicators improve and the success rate of attribute inference attacks remains largely unchanged. These results provide practical guidance for selecting thresholds and applying post hoc repairs to improve the quality and empirical privacy of synthetic tabular data, while complementing approaches that provide formal differential privacy guarantees.

cs.LG↗

arXiv2025

Migrating QAOA from Qiskit 1.x to 2.x: An experience report

Migrating quantum algorithms across evolving frameworks introduces subtle behavioral changes that affect accuracy and reproducibility. This paper reports our experience converting the Quantum Approximate Optimization Algorithm (QAOA) from Qiskit Algorithms with Qiskit 1.x (v1 primitives) to a custom implementation using Qiskit 2.x (v2 primitives). Despite identical circuits, optimizers, and Hamiltonians, the new version produced drastically different results. A systematic analysis revealed the root cause: the sampling budget -- the number of circuit executions (shots) per iteration. The library's implicit use of unlimited shots yielded dense probability distributions, whereas the v2 default of 10 000 shots captured only 23% of the state space. Increasing shots to 250 000 restored library-level accuracy. This study highlights how hidden parameters at the quantum-classical interaction level can dominate hybrid algorithm performance and provides actionable recommendations for developers and framework designers to ensure reproducible results in quantum software migration.

cs.SE↗

arXiv2025

Data Complexity: a threshold between Classical and Quantum Machine Learning -- Part I

Quantum machine learning (QML) holds promise for accelerating pattern recognition, optimization, and data analysis, but the conditions under which it can truly outperform classical approaches remain unclear. Existing research often emphasizes algorithms and hardware, while the role of data itself in determining quantum advantage has received less attention. We argue that data complexity -- the structural, statistical, algorithmic, and topological richness of datasets -- is central to defining these conditions. Beyond qubit counts or circuit depth, the real bottleneck lies in the cost of embedding, representing, and generalizing from data. In this paper (Part I of a two-part series), we review classical and quantum metrics of data complexity, including entropy, correlations, compressibility, and topological invariants such as persistent homology and topological entanglement entropy. We also examine their implications for trainability, scalability, and error tolerance in QML. Part II will develop a unified framework and provide empirical benchmarks across datasets, linking these complexity measures to practical performance.

quant-ph↗

arXiv2025

Mid-circuit measurement as an algorithmic primitive

We explore the usefulness of mid-circuit measurements to enhance quantum algorithmics. Specifically, we assess how quantum phase estimation (QPE) and mid-circuit measurements can improve the performance of variational quantum algorithms. Our focus is on the single-qubit version of QPE namely, the Hadamard test applied to the Quantum Approximate Optimization Algorithm (QAOA) ansatz. We demonstrate that a mid-circuit measurement acts as a low-energy filter when the desired outcome is obtained. When the other outcome is measured we heuristically rely on the mixer to repopulate the low energy states. Numerical simulations show that this method effectively amplifies the ground state. We validate our approach on real quantum hardware namely the IBM Quantum system one ibm_quebec.

quant-ph↗

arXiv2025

CHSH Violations using Dynamic Circuits

Scalable quantum computing relies on high-quality, long-range entanglement, a challenge on noisy, near-term devices. The need for practical insights for near-term algorithm design calls for trade-offs exploration in implementing dynamic circuits on current hardware. In this work, we experimentally compare three CNOT implementations for generating Bell states across varying qubit separations on a 127-qubit IBM Quantum Eagle processor (ibm_quebec): a unitary (SWAP-based) approach, a dynamic approach with mid-circuit measurements and classical feedforward, and a post-processed approach. We use Clauser-Horne-Shimony-Holt (CHSH) inequality violations to quantify entanglement quality. We observe that, beyond 10 qubits, dynamic circuits lead to higher |S| values than the unitary approach, demonstrating improved distance-dependent entanglement preservation. The post-processed approach yields the highest CHSH values, reaching |S| > 2 up to 13 qubits. Our results underscore the critical need for faster classical feedforward and higher readout fidelity.

quant-ph↗

arXiv2025

EAQGA: A Quantum-Enhanced Genetic Algorithm with Novel Entanglement-Aware Crossovers

Genetic algorithms are highly effective optimization techniques for many computationally challenging problems, including combinatorial optimization tasks like portfolio optimization. Quantum computing has also shown potential in addressing these complex challenges. Combining these approaches, quantum genetic algorithms leverage the principles of superposition and entanglement to enhance the performance of classical genetic algorithms. In this work, we propose a novel quantum genetic algorithm introducing an innovative crossover strategy to generate quantum circuits from a binary solution. We incorporate a heuristic method to encode entanglement patterns from parent solutions into circuits for the next generation. Our algorithm advances quantum genetic algorithms by utilizing a limited number of entanglements, enabling efficient exploration of optimal solutions without significantly increasing circuit depth, making it suitable for near-term applications. We test this approach on a portfolio optimization problem using an IBM 127 qubits Eagle processor (ibm_quebec) and simulators. Compared to state-of-the-art algorithms, our results show that the proposed method improves fitness values by 33.6% over classical genetic algorithm and 37.2% over quantum-inspired genetic algorithm, using the same iteration counts and population sizes with real quantum hardware employing 100 qubits. These findings highlight the potential of current quantum computers to address real-world utility-scale combinatorial optimization problems.

cs.ET↗

arXiv2024

XGSwap: eXtreme Gradient boosting Swap for Routing in NISQ Devices

In the current landscape of noisy intermediate-scale quantum (NISQ) computing, the inherent noise presents significant challenges to achieving high-fidelity long-range entanglement. Furthermore, this challenge is amplified by the limited connectivity of current superconducting devices, necessitating state permutations to establish long-distance entanglement. Traditionally, graph methods are used to satisfy the coupling constraints of a given architecture by routing states along the shortest undirected path between qubits. In this work, we introduce a gradient boosting machine learning model to predict the fidelity of alternative--potentially longer--routing paths to improve fidelity. This model was trained on 4050 random CNOT gates ranging in length from 2 to 100+ qubits. The experiments were all executed on ibm_quebec, a 127-qubit IBM Quantum System One. Through more than 200+ tests run on actual hardware, our model successfully identified higher fidelity paths in approximately 23% of cases.

quant-ph↗

arXiv2024

Noise Aware Utility Optimization of NISQ Devices

In order to enter the era of utility, noisy intermediate-scale quantum (NISQ) devices need to enable long-range entanglement of large qubit chains. However, due to the limited connectivity of superconducting NISQ devices, long-range entangling gates are realized in linear depth. Furthermore, a time-dependent degradation of the average CNOT gate fidelity is observed. Likely due to aging, this phenomenon further degrades entanglement capabilities. Our aim is to help in the current efforts to achieve utility and provide an opportunity to extend the utility lifespan of current devices --albeit by selecting fewer, high quality resources. To achieve this, we provide a method to transform user-provided CNOT and readout error requirements into a compliant partition onto which circuits can be executed. We demonstrate an improvement of up to 52% in fidelity for a random CNOT chain of length 50 qubits and consistent improvements between 11.8% and 47.7% for chains between 10 and 40 in varying in increments of 10, respectively.

quant-ph↗

arXiv2022

A preprocessing perspective for quantum machine learning classification advantage using NISQ algorithms

Quantum Machine Learning (QML) hasn't yet demonstrated extensively and clearly its advantages compared to the classical machine learning approach. So far, there are only specific cases where some quantum-inspired techniques have achieved small incremental advantages, and a few experimental cases in hybrid quantum computing are promising considering a mid-term future (not taking into account the achievements purely associated with optimization using quantum-classical algorithms). The current quantum computers are noisy and have few qubits to test, making it difficult to demonstrate the current and potential quantum advantage of QML methods. This study shows that we can achieve better classical encoding and performance of quantum classifiers by using Linear Discriminant Analysis (LDA) during the data preprocessing step. As a result, Variational Quantum Algorithm (VQA) shows a gain of performance in balanced accuracy with the LDA technique and outperforms baseline classical classifiers.

quant-ph↗