arXiv subjects

Christophe Prud'Homme

Publications and source records attributed to Christophe Prud'Homme.

14 recordsLinked to original sources

arXiv2026

Mathematical modeling and simulation of coupled aqueous humor flow and temperature distribution in a realistic 3D human eye geometry

We present a comprehensive computational model to simulate the coupled dynamics of aqueous humor flow and heat transfer in the human eye. To manage the complexity of the model, we make significant efforts in meshing and efficient solution of the discrete problem using high-performance resources. The model accurately describes the dynamics of the aqueous humor in the anterior and posterior chambers and accounts for convective effects due to temperature variations. Results for fluid velocity, pressure, and temperature distribution are in good agreement with existing numerical results in the literature. Furthermore, the effects of postural changes and wall shear stress behavior are analyzed, providing new insights into the mechanical forces acting on ocular tissues. Overall, the present contribution provides a detailed three-dimensional simulation that enhances the understanding of ocular physiology and may contribute to further progress in clinical research and treatment optimization in ophthalmology.

math.AP↗

arXiv2025

Two-way Coupling of Fluid--Structure Interaction for Elastic Magneto-Swimmers:A Finite Element ALE Approach

Artificial micro-swimmers actuated by external magnetic fields hold significant promise for targeted biomedical applications, including drug delivery and micro-robot-assisted therapy. However, their dynamics remain challenging to control due to the complex nonlinear coupling between magnetic actuation, elastic deformations, and fluid interactions in confined biological environments. Numerical modeling is therefore essential to better understand, predict, and optimize their behavior for practical applications. In this work, we present a comprehensive finite element framework based on the Arbitrary Lagrangian--Eulerian formulation to simulate deformable elastic micro-swimmers in confined fluid domains. The method employs a full-order model that resolves the complete fluid dynamics while simultaneously tracking swimmer deformation and global displacement on conforming meshes. Numerical experiments are performed with the open-source finite element library Feel++, demonstrating excellent agreement with experimental data from the literature. The validation benchmarks in both two and three dimensions confirm the accuracy, robustness, and computational efficiency of the proposed framework, representing a foundational step toward developing digital twins of magneto-swimmers for biomedical applications.

math.AP↗

arXiv2024

Model order reduction and sensitivity analysis for complex heat transfer simulations inside the human eyeball

Heat transfer in the human eyeball, a complex organ, is significantly influenced by various pathophysiological and external parameters. Particularly, heat transfer critically affects fluid behavior within the eye and ocular drug delivery processes. Overcoming the challenges of experimental analysis, this study introduces a comprehensive three-dimensional mathematical and computational model to simulate the heat transfer in a realistic geometry. Our work includes an extensive sensitivity analysis to address uncertainties and delineate the impact of different variables on heat distribution in ocular tissues. To manage the model's complexity, we employed a very fast model reduction technique with certified sharp error bounds, ensuring computational efficiency without compromising accuracy. Our results demonstrate remarkable consistency with experimental observations and align closely with existing numerical findings in the literature. Crucially, our findings underscore the significant role of blood flowand environmental conditions, particularly in the eye's internal tissues. Clinically, this model offers a promising tool for examining the temperature-related effects of various therapeutic interventions on the eye. Such insights are invaluable for optimizing treatment strategies in ophthalmology.

math.AP↗

arXiv2024

Towards a computational framework using finite element methods with Arbitrary Lagrangian-Eulerian approach for swimmers with contact

Swimming involves a body's capability to navigate through a fluid by undergoing self-deformations. Typically, fluid dynamics are described by the Navier-Stokes equations, and when integrated with a swimming body, it results in a highly intricate model. This paper introduces a computational framework for simulating the movement of multiple swimmers with various geometries immersed in a Navier-Stokes fluid. The approach relies on the finite element method with an Arbitrary Lagrangian-Eulerian (ALE) framework to handle swimmer displacements. Numerous numerical experiments demonstrate the adaptability of the computational framework across various scenarios.All the implementations are made using the Feel++ finite element library.

math.AP↗

arXiv2024

Ktirio Urban Building: A Computational Framework for City Energy Simulations Enhanced by CI/CD Innovations on EuroHPC Systems

The building sector in the European Union significantly impacts energy consumption and greenhouse gas emissions. The EU's Horizon 2050 initiative sets ambitious goals to reduce these impacts through enhanced building renovation rates. The CoE HiDALGO2 supports this initiative by developing high-performance computing solutions, specifically through the Urban Building pilot application, which utilizes advanced CI/CD methodologies to streamline simulation and deployment across various computational platforms, such as the EuroHPC JU supercomputers. The present work provides an overview of the Ktirio Urban Building framework (KUB), starting with an overview of the workflow and a description of some of the main ingredients of the software stack and discusses some current results performed on EuroHPC JU supercomputers using an innovative CI/CD pipeline.

cs.DC↗

arXiv2024

Nonlinear compressive reduced basis approximation for multi-parameter elliptic problem

Reduced basis methods for approximating the solutions of parameter-dependant partial differential equations (PDEs) are based on learning the structure of the set of solutions - seen as a manifold ${\mathcal S}$ in some functional space - when the parameters vary. This involves investigating the manifold and, in particular, understanding whether it is close to a low-dimensional affine space. This leads to the notion of Kolmogorov $N$-width that consists of evaluating to which extent the best choice of a vectorial space of dimension $N$ approximates ${\mathcal S}$ well enough. If a good approximation of elements in ${\mathcal S}$ can be done with some well-chosen vectorial space of dimension $N$ -- provided $N$ is not too large -- then a ``reduced'' basis can be proposed that leads to a Galerkin type method for the approximation of any element in ${\mathcal S}$. In many cases, however, the Kolmogorov $N$-width is not so small, even if the parameter set lies in a space of small dimension yielding a manifold with small dimension. In terms of complexity reduction, this gap between the small dimension of the manifold and the large Kolmogorov $N$-width can be explained by the fact that the Kolmogorov $N$-width is linear while, in contrast, the dependency in the parameter is, most often, non-linear. There have been many contributions aiming at reconciling these two statements, either based on deterministic or AI approaches. We investigate here further a new paradigm that, in some sense, merges these two aspects: the nonlinear compressive reduced basisapproximation. We focus on a simple multiparameter problem and illustrate rigorously that the complexity associated with the approximation of the solution to the parameter dependant PDE is directly related to the number of parameters rather than the Kolmogorov $N$-width.

math.NA↗

arXiv2024

A coupled fluid-dynamics-heat transfer model for 3D simulations of the aqueous humor flow in the human eye

Understanding human eye behavior involves intricate interactions between physical phenomena such as heat transfer and fluid dynamics. Accurate computational models are vital for comprehending ocular diseases and therapeutic interventions.This work focuses on modeling and simulating aqueous humor flow in the anterior and posterior chambers of the eye, coupled with overall heat transfer.Aqueous humor dynamics regulates intraocular pressure, crucial for understanding conditions like glaucoma.Convective effects from temperature disparities also influence this flow.Extending prior research, this work develops a comprehensive three-dimensional computational model to simulate coupled fluid-dynamic-heat transfer model, thus contributing to the understanding of ocular physiology.

math.AP↗

arXiv2024

Mathematical and computational framework for moving and colliding rigid bodies in a Newtonian fluid

We studied numerically the dynamics of colliding rigid bodies in a Newtonian fluid. The finite element method is used to solve the fluid-body interaction and the fluid motion is described in the Arbitrary-Lagrangian-Eulerian framework. To model the interactions between bodies, we consider a repulsive collision-avoidance model, defined by R. Glowinski. The main emphasis in this work is the generalization of this collision model to multiple rigid bodies of arbitrary shape. Our model first uses a narrow-band fast marching method to detect the set of colliding bodies. Then, collision forces and torques are computed for these bodies via a general expression, which does not depend on their shape. Numerical experiments examining the performance of the narrow-band fast marching method and the parallel execution of the collision algorithm are discussed. We validate our model with literature results and show various applications of colliding bodies in two and three dimensions. In these applications, the bodies move due to forces such as gravity, a fluid flow, or their own actuation. Finally, we present a tool to create arbitrarily shaped bodies in discretized fluid domains, enabling conforming body-fluid interface and allowing to perform simulations of fluid-body interactions with collision treatment in these realistic environments. All simulations are conducted with the Feel++ open source library.

math.AP↗

arXiv2021

Shapes enhancing the propulsion of multiflagellated helical microswimmers

In this paper we are interested in optimizing the shape of multi-flagellated helical microswimmers. Mimicking the propagation of helical waves along the flagella, they self-propel by rotating their tails. The swimmer's dynamics is computed using the Boundary Element Method, implemented in the open source Matlab library $Gypsilab$. We exploit a Bayesian optimization algorithm to maximize the swimmer's speeds through their shape optimization. Our results show that the optimal tail shapes are helices with large wavelength, such that the shape periodicity is disregarded. Moreover, the best propulsion speed is achieved for elongated heads when the swimmer has one or two flagella. Surprisingly, a round head is obtained when more flagella are considered. Our results indicate that the position and number of flagella modify the propulsion pattern and play a significant role in the optimal design of the head. It appears that Bayesian optimization is a promising method for performance improvement in microswimming.

cond-mat.soft↗

arXiv2021

Uncertainty propagation and sensitivity analysis: results from the Ocular Mathematical Virtual Simulator

We propose an uncertainty propagation study and a sensitivity analysis with the Ocular Mathematical Virtual Simulator, a computational and mathematical model that predicts the hemodynamics and biomechanics within the human eye. In this contribution, we focus on the effect of intraocular pressure, retrolaminar tissue pressure and systemic blood pressure on the ocular posterior tissue vasculature. The combination of a physically-based model with experiments-based stochastic input allows us to gain a better understanding of the physiological system, accounting both for the driving mechanisms and the data variability.

math.NA↗

arXiv2019

Swimming at Low Reynolds Number

We address the swimming problem at low Reynolds number. This regime, which is typically used for micro-swimmers, is described by Stokes equations. We couple a PDE solver of Stokes equations, derived from the Feel++ finite elements library, to a quaternion-based rigid-body solver. We validate our numerical results both on a 2D exact solution and on an exact solution for a rotating rigid body respectively. Finally, we apply them to simulate the motion of a one-hinged swimmer, which obeys to the scallop theorem.

math.AP↗

arXiv2017

High order finite element simulations for fluid dynamics validated by experimental data from the fda benchmark nozzle model

The objective of the present work is to construct a sound mathematical, numerical and computational framework relevant to blood flow simulations and to assess it through a careful validation against experimental data. We perform simulations of a benchmark proposed by the FDA for fluid flow in an idealized medical device, under different flow regimes. The results are evaluated using metrics proposed in the literature and the findings are in very good agreement with the validation experiment.

math.AP↗

arXiv2015

Simultaneous Empirical Interpolation and Reduced Basis method for non-linear problems

In this paper, we focus on the reduced basis methodology in the context of non-linear non-affinely parametrized partial differential equations in which affine decomposition necessary for the reduced basis methodology are not obtained [4, 3]. To deal with this issue, it is now standard to apply the EIM methodology [8, 9] before deploying the Reduced Basis (RB) methodology. However the computational cost is generally huge as it requires many finite element solves, hence making it inefficient, to build the EIM approximation of the non-linear terms [9, 1]. We propose a simultaneous EIM Reduced basis algorithm, named SER, that provides a huge computational gain and requires as little as N + 1 finite element solves where N is the dimension of the RB approximation. The paper is organized as follows: we first review the EIM and RB methodologies applied to non-linear problems and identify the main issue, then we present SER and some variants and finally illustrates its performances in a benchmark proposed in [9].

math.AP↗

arXiv2012

Simulation of two-fluid flows using a Finite Element/level set method. Application to bubbles and vesicle dynamics

A new framework for two-fluids flow using a Finite Element/Level Set method is presented and verified through the simulation of the rising of a bubble in a viscous fluid. This model is then enriched to deal with vesicles (which mimic red blood cells mechanical behavior) by introducing a Lagrange multiplier to constrain the inextensibility of the membrane. Moreover, high order polynomial approximation is used to increase the accuracy of the simulations. A validation of this model is finally presented on known behaviors of vesicles under flow such as "tank treading" and tumbling motions.

math.NA↗