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Christopher Kazu Williams

Publications and source records attributed to Christopher Kazu Williams.

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Augmenting Pathologists with NaviPath: Design and Evaluation of a Human-AI Collaborative Navigation System

Artificial Intelligence (AI) brings advancements to support pathologists in navigating high-resolution tumor images to search for pathology patterns of interest. However, existing AI-assisted tools have not realized this promised potential due to a lack of insight into pathology and HCI considerations for pathologists' navigation workflows in practice. We first conducted a formative study with six medical professionals in pathology to capture their navigation strategies. By incorporating our observations along with the pathologists' domain knowledge, we designed NaviPath -- a human-AI collaborative navigation system. An evaluation study with 15 medical professionals in pathology indicated that: (i) compared to the manual navigation, participants saw more than twice the number of pathological patterns in unit time with NaviPath, and (ii) participants achieved higher precision and recall against the AI and the manual navigation on average. Further qualitative analysis revealed that navigation was more consistent with NaviPath, which can improve the overall examination quality.

cs.HC

Improving Workflow Integration with xPath: Design and Evaluation of a Human-AI Diagnosis System in Pathology

Recent developments in AI have provided assisting tools to support pathologists' diagnoses. However, it remains challenging to incorporate such tools into pathologists' practice; one main concern is AI's insufficient workflow integration with medical decisions. We observed pathologists' examination and discovered that the main hindering factor to integrate AI is its incompatibility with pathologists' workflow. To bridge the gap between pathologists and AI, we developed a human-AI collaborative diagnosis tool -- xPath -- that shares a similar examination process to that of pathologists, which can improve AI's integration into their routine examination. The viability of xPath is confirmed by a technical evaluation and work sessions with twelve medical professionals in pathology. This work identifies and addresses the challenge of incorporating AI models into pathology, which can offer first-hand knowledge about how HCI researchers can work with medical professionals side-by-side to bring technological advances to medical tasks towards practical applications.

cs.HC

Detecting Mitoses with a Convolutional Neural Network for MIDOG 2022 Challenge

This work presents a mitosis detection method with only one vanilla Convolutional Neural Network (CNN). Our method consists of two steps: given an image, we first apply a CNN using a sliding window technique to extract patches that have mitoses; we then calculate each extracted patch's class activation map to obtain the mitosis's precise location. To increase the model performance on high-domain-variance pathology images, we train the CNN with a data augmentation pipeline, a noise-tolerant loss that copes with unlabeled images, and a multi-rounded active learning strategy. In the MIDOG 2022 challenge, our approach, with an EfficientNet-b3 CNN model, achieved an overall F1 score of 0.7323 in the preliminary test phase, and 0.6847 in the final test phase (task 1). Our approach sheds light on the broader applicability of class activation maps for object detections in pathology images.

cs.CV